High-dose loperamide in the treatment of 5-fluorouracil-induced diarrhea in colorectal cancer patients

Supportive Care in Cancer

Volumn 8, Issue 1, 2000, Pages 65-67

  Cascinu, Stefano ^a,d,e   Bichisao, Ettore ^b   Amadori, Dino ^c   Silingardi, Vittorio ^f   Giordani, Paolo ^a   Sansoni, Elisabetta ^c   Luppi, Gabriele ^f   Catalano, Vincenzo ^a   Agostinelli, Romina ^a   Catalano, Giuseppina ^a  

^a Azienda Ospedaliera Osp S S   (Italy)

^b Medical Department Novartis   (Italy)

^c MORGAGNI PIERANTONI HOSPITAL   (Italy)

^d Ospedale di Muraglia   (Italy)

^e UNIVERSITY OF MESSINA   (Italy)

^f NONE

Author keywords

5 Fluorouracil; Diarrhea; Loperamide

Indexed keywords

FLUOROURACIL; LOPERAMIDE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; COLORECTAL CANCER; DIARRHEA; DRUG EFFICACY; DRUG MEGADOSE; DRUG RESPONSE; DRUG SCREENING; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; TREATMENT OUTCOME;

EID: 0033953648     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005209900085     Document Type: Article

References (12)

1. Grem JI (1990) Fluorinated pyrimidines. In: Chabner BA, Collins JM (eds) Cancer chemotherapy, principles and practice. Lippincott, Philadelphia, pp 180-225
2. Cascinu S (1995) Drug therapy in diarrheal disease in oncology/hematology patients. Crit Rev Oncol/Hematol 18:37-50
3. Cascinu S, Fedeli A, Luzi Fedeli S, Catalano G (1992) Control of chemotherapy-induced diarrhea with octreotide in patients receiving 5-fluorouracil. Eur J Cancer 28:482-483
4. Cascinu S, Fedeli A, Luzi Fedeli S, Catalano G (1993) Octreotide versus loperamide in the treatment of fluorouracil induced diarrhea: a randomized trial. J Clin Oncol 11:148-151
5. Petrelli NJ, Rodriguez-Bigas M, Rustum Y, Herrera L, Creaven P (1993) Bowel rest, intravenous hydration and continuous high-dose infusion of octerotide acetate for the treatment of chemotherapy-induced diarrhea in patients with colorectal carcinoma. Cancer 72:1543-1546
6. Wadler S, Haynes H, Wiernik PH (1995) Phase I trial of the somatostatin analog octreotide acetate in the treatment of fluoropyrimidine-induced diarrhea. J Clin Oncol 13:222-226
7. Ericsson CD, Johnson PC (1990) Safety and efficacy of loperamide. Am J Med 20:10-14
8. Daugherty LM (1990) Loperamide hydrochloride. Am Pharm 12:45-48
9. Moertel CG (1994) Chemotherapy for colorectal cancer. N Engl J Med 330:1136-1142
10. Sthal KS, van Bever W, Janssen P, et al (1977) Receptor activity and pharmacological potency of a series of narcotic analgesic, antidiarrheal and neurological drugs. Eur J Pharmacol 46:199-205
11. Cornet J, Aspeling R, Mallegol D (1977) A double-blind comparative evaluation of loperamide versus diphenoxylate with atropine in acute diarrhea. Curr Ther Res 21:629-637
12. Abigerges D, Armand JP, Chabot GG, Da Costa L, Fadel E, Cote C, Herait P, Gandia D (1994) Irinotecan (CPT-11) high-dose escalation using intensive high-dose loperamide to control diarrhea. J Natl Cancer Inst 86:446-449