An assessment of neurotoxicity of Aroclors 1016, 1242, 1254, and 1260 administered in diet to Sprague-Dawley rats for one year

Toxicological Sciences

Volumn 53, Issue 2, 2000, Pages 377-391

  Freeman, G B ^a,e   Lordo, R A ^a   Singer, A W ^a   Peters, A C ^a   Neal, B H ^b   McConnell, E E ^c   Mayes, B A ^d  

^a BATTELLE MEMORIAL INSTITUTE   (United States)

^b JSC Inc   (United States)

^c ToxPath Inc   (United States)

^d GENERAL ELECTRIC COMPANY   (United States)

^e PFIZER INC   (United States)

Author keywords

Aroclor; Chronic toxicity; Neurotoxicity; Oncogenicity; PCBs; Rats

Indexed keywords

AROCLOR;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CHRONIC TOXICITY; CONTROLLED STUDY; DIET; FEMALE; HISTOPATHOLOGY; MALE; MOTOR ACTIVITY; NEUROTOXICITY; NONHUMAN; RAT;

EID: 0033953260     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/53.2.377     Document Type: Article

References (45)

1. Agrawal, A. K., Tilson, H. A., and Bondy, S. C. (1981). 3,4,3′,4′-Tetrachlorobiphenyl given to mice prenatally produces long term decreases in striatal dopamine and receptor binding sites in the caudate nucleus. Toxicol. Lett. 7, 417-424.
2. ATSDR. (1996). Toxicological Profile for Selected PCBs (Aroclor 1260, -1254, -1248, -1242, -1232, -1221, and -1016).
3. Bowman, R. E., and Heironimus, M. P. (1981). Hypoactivity in adolescent monkeys perinatally exposed to PCBs and hyperactive as juveniles. Neurobehav. Toxicol. Teratol. 3, 15-18.
4. Bowman, R. E., Heironimus, M. P., and Allen, J. R. (1978). Correlation of PCB body burden with behavioral toxicology in monkeys. Pharmacol. Biochem. Behav., 9, 49.
5. Bowman, R. E., Heironimus, M. P., and Barsotti, D. A. (1981). Locomotor hyperactivity in PCB-exposed rhesus monkeys. Neurotoxicology 2, 251-268.
6. Boysen, B., Nold, J., Alsaker, R., Weiler, M., Meehan, J. (1993). A Method for Preparing Sections and Documenting the Neurohistopathologic Evaluation of Subanatomic Areas of Rat Brain in Regulated Neurotoxicity Studies. Poster N-4, 44th Annual ACVP Meeting.
7. Burek, J. D. (1978). Pathology of Aging Rats. CRC Press, Inc., West Palm Beach, Florida.
8. Chen, P. H., and Hites, R. A. (1983). Polychlorinated biphenyls and dibenzofurans retained in the tissues of a deceased patient with Yucheng in Taiwan. Chemosphere 12, 1507-1516.
9. Chia, L. G., and Chu, F. L. (1984). Neurological studies on polychlorinated biphenyl (PCB) poisoned patients. In Progress in Clinical Biological Research Poisoning in Japan and Taiwan (M. Kuratsune and R. E. Shapiro, Eds.), Vol. 137, pp. 117-126. A. R. Liss, New York.
10. Chou, S. M., Miike, T., Payne, W. M., and Davis, G. J. (1979). Neuropathology of "spinning syndrome" induced by prenatal intoxication with a PCB in mice. Ann. NY Acad. Sci. 320, 373-396.
11. Fischbein, A., Wolff, M. S., Lilis, R., Thornton, J., and Selikoff, I. J. (1979). Clinical findings among PCB-exposed capacitor manufacturing workers. Ann. N.Y. Acad. Sci. 320, 703-715.
12. Gladen, B. C., Rogan, W. J., Hardy, P., Thullen, J., Tingelstad, J., and Tully, M. (1988). Development after exposure to polychlorinated biphenyls and dichlorodiphenyl dichloroethene transplacentally and through human milk. J. Pediatr. 113, 991-995.
13. Jacobson, S. W., Fein, G. G., Jacobson, J. L., Schwarte, P. M., and Dowler, J. K. (1985). The effect of intrauterine PCB exposure on visual recognition memory. Child Dev. 56, 853-860.
14. Jacobson, J. L., Humphrey, H.E.B., Jacobson, S. W., Schantz, S. L., Mullin, M. D., and Welch, R. (1989). Determinants of polychlorinated biphenyls (PCBs), polybrominated biphenyls (PBBs), and dichlorodiphenyl trichloroethane (DDT) levels in the sera of young children. Am. J. Public Health 79, 1401-1404.
15. Jacobson, J. L., Jacobson, S. W., and Humphrey, H.E.B. (1990a). Effects of in utero exposure to polychlorinated biphenyls and related contaminants on cognitive functioning in young children. J. Pediatr. 116, 38-45.
16. Jacobson, J. L., Jacobson, S. W., and Humphrey, H. E. B. (1990b). Effects of exposure to PCBs and related compounds on growth and activity in children. Neurotoxicol. Teratol. 12, 319-326.
17. Jortner, B. S., and Percy, D. H. (1978). The nervous system. In Pathology of Laboratory Animals (K. Benirschke, F. M. Garner, and T. C. Jones, Eds.) Springer-Verlag, New York.
18. Kikuchi, M., Shigematsu, N., and Umeda, G. (1979). Autopsy report of two Yusho patients who died nine years after onset. Fukuoka Igaku Zasshi 70, 215-222.
19. King, R. (1994). Changes in the peripheral nervous system. In Pathobiology of the Aging Rat, Vol. 2, (U. Mohr, D. L. Dungworth, and C. C. Capen, Eds.) ILSI Press, Washington, D.C.
20. Koopman-Esseboom, C. Weiglas-Kuperus, N., de Ridder, J. A. J., van der Paauw, C. G., Tuinstra, L.G.M.T., and Sauer, P. J. J. (1996). Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants' mental and psychomotor development. Pediatrics 97, 700-706.
21. Kuratsune, M., Youshimara, T., Matsuzaka, J., and Yamaguchi, A. (1972). Epidemiologic study on Yusho: A poisoning caused by ingestion of rice oil contaminated with a commercial brand of polychlorinated biphenyls. Environ. Health Perspect. 1, 119-128.
22. Levin, E. D., Schantz, S. L., and Bowman, R. E. (1988). Delayed spatial alteration deficits resulting from perinatal PCB exposure in monkeys. Arch. Toxicol. 62, 267-273.
23. Lonky, E., Reihman, J., Darvill, T., Mather, J., Sr., Daly, H. (1996). Neonatal behavioral assessment scale performance in humans influenced by maternal consumption of environmentally contaminated Lake Ontario fish. J. Great Lakes Res. 22, 198-212.
24. Mayes, B. A., McConnell, E. E., Neal, B. H., Brunner, M. J., Hamilton, S. B., Sullivan, T. M., Peters, A. C., Ryan, M. J., Toft, J. D., Singer, A. W., Brown, J. F., Jr., Menton, R. G., and Moore, J. A. (1998). Comparative carcinogenicity in Sprague-Dawley rats of the polychlorinated biphenyl mixtures Aroclors 1016, 1242, 1254, and 1260. Toxicol Sci. 41, 62-76.
25. Mele, P. C., Bowman, R. E., and Levin, E. D. (1986). Behavioral evaluation of perinatal PCB exposure in rhesus monkeys: Fixed-interval performance and reinforcement-omission. Neurobehav. Toxicol. Teratol., 8, 131.
26. Mitsumori, K., and Boorman, G. A. (1990). Spinal cord and peripheral nerves. In Pathology of the Fischer Rat. (G. A. Boorman, S. L. Eustis, M. R. Elwell, C. A. Montgomery, Jr., and W. F. MacKenzie, Eds.) Academic Press, Inc., San Diego, California.
27. Murai, Y., and Kuroiwa, Y. (1971). Peripheral neuropathy in chlorobiphenyl poisoning. Neurology 21, 1173-1176.
28. Nishida, N., Farmer, J. D., Kodavanti, P. R., Tilson, H. A., MacPhail, R. C. (1997). Effects of acute and repeated exposures to Aroclor 1254 in adult rats: motor activity and flavor aversion conditioning. Fundam. Appl. Toxicol. 40(1), 68-74.
29. Pantaleoni, G., Fanini, D., Sponta, A. M., Palumbo, G., Giorgi, R., and Adams, P. (1988). Effects of maternal exposure to polychlorinated biphenyls (PCBs) on F1 generation behavior in the rat. Fundam. Appl. Toxicol. 11, 440-449.
30. Patandin, S., Lanting, C. I., Mulder, P. G., Boersma, E. R., Sauer, P. J., and Weisglas-Kuperus, N. (1999). Effects of environmental exposure to polychlorinated biphenyls and dioxins on cognitive abilities in Dutch children at 42 months of age. J. Pediatr. 134(1), 33-41.
31. Rogan, W. J., Gladen, B. C., McKinney, J. D., Carreras, N., Hardy, P., Thullen, J. D., Tinglestad, J., and Tully, M. (1986). Neonatal effects of transplacental exposure to PCBs and DDE. J. Pediatr. 109, 335-341.
32. Rogan, W. J., Gladen, B. C., Hung, K. L., Koong, S. L., Shih, L. Y., Taylor, J. S., Wu, Y. C., Yang, D., Rogan, N. B., and Hsu, C. C. (1988). Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan. Science 241, 334-336.
33. Schantz, S. L., (1996). Developmental neurotoxicity of PCBs in humans: What do we know and where do we go from here? Neurotoxicol. Teratol. 18, 217-227.
34. Schantz, S. L., Jacobson, J. L., Jacobson, S. W., and Humphrey, H.E.B. (1990). Behavioral correlates of polychlorinated biphenyl (PCB) body burden in school-aged children. Toxicologist 10, 303.
35. Schantz, S. L., Levin, E. D., Bowman, R. E., Heironimus, M. P., and Laughlin, N. K. (1989). Effects of perinatal PCB exposure on discrimination-reversal learning in monkeys. Neurotoxicol. Teratol., 11, 243-250.
36. Seegal, R. F. (1996). Epidemiological and laboratory evidence of PCB-induced neurotoxicity. Crit. Rev. Toxicol. 26, 709-737.
37. Seegal, R. F., Brosch, K. O., and Bush, B. (1986). Polychlorinated biphenyls produce regional alteration of dopamine metabolism in rat brain. Toxicol. Lett. 80, 197-202.
38. Seegal, R. F., Bush, B., and Brosch, K. O. (1991a). Subchronic exposure of the rat to Aroclor 1254 selectively alters central dopaminergic function. Neurotoxicology 12, 55-66.
39. Seegal, R. F., Bush, B., and Brosch, K. O. (1991b). Comparison of the effects of Aroclors 1016 and 1260 on non-human primate catecholamine function. Toxicology 66, 145-163.
40. Seegal, R. F., Bush, B., and Brosch, K. O. (1994). Decreases in dopamine concentrations in adult, non-human primate brain persist following removal from polychlorinated biphenyls. Toxicology 86, 71-87.
41. Seegal, R. F., Bush, B., and Shain, W. (1990). Lightly chlorinated orthosubstituted PCB congeners decrease dopamine in nonhuman primate brain and in tissue culture. Toxicol. Appl. Pharmacol. 106, 136-144.
42. Silkworth, J. B., Mayes, B. A., Hamilton, S. B., Moore, J. A., and Brown, J. F., Jr. (1995). Sex differences in the tissue accumulation of metabolic profiles of Aroclors 1016, 1242, 1254, and 1260 in Sprague-Dawley rats. The Toxicologist 15, 189.
43. Storm, J. E., Hart, J. L., and Smith, R. F. (1981). Behavior of mice after pre-and postnatal exposure to Aroclor 1254. Neurobehav. Toxicol. Teratol. 3, 5-9.
44. Tilson, H. A., Davis, G. J., McLachlan, J. A., Lucier, G. W. (1979). The effects of polychlorinated biphenyls given prenatally on the neurobehavioral development of mice. Environ. Res. 18, 466-474.
45. U.S. EPA Neurotoxicity Guidelines (Pesticide Assessment Guidelines, Subdivision F, Hazard Evaluation: Human and Domestic Animals, Addendum 10: EPA-540/09-91-123, March, 1991.