Neoplastic transformation of mammary epithelial cells in rats is associated with decreased apoptotic cell death

Carcinogenesis

Volumn 21, Issue 2, 2000, Pages 227-233

  Shilkaitis, Anne ^a   Green, Albert ^a   Steele, Vernon ^b   Lubet, Ronald ^b   Kelloff, Carry ^b   Christov, Konstantin ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; METHYLNITROSOUREA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BREAST CARCINOGENESIS; BREAST DUCT; BREAST EPITHELIUM; BREAST HYPERPLASIA; CARCINOMA IN SITU; CELL PROLIFERATION; CELL TRANSFORMATION; CONTROLLED STUDY; FEMALE; LABELING INDEX; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033953012     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.2.227     Document Type: Article

References (35)

1. Gulliano, P.M., Peltigrew, H.M. and Grantham, F.H. (1975) N-Nitrosomethylurea as mammary gland carcinogen in rats. J. Natl Cancer Inst., 54, 401-414.
2. Moon, R.C., Thompson, H.J., Becci, P.J., Grubbs, C.J., Gander, R.J., Newton, D.L., Smith, J.M., Phillips, S.R., Henderson, W.R., Mullen, L.T., Brown, C.C and Sporn, M.B. (1979) N-4 (Hydroxyphenyl)retinamide, a new retinoid for prevention of breast cancer in the rat. Cancer Res., 39, 1339-1346.
3. Moon, R,C., Mehta, R.C. and Rao, K.V.N. (1994) Retinoids and cancer in experimental animals. In Sporn, M., Roberts, A. and Guoodman, D.S. (eds) The Retinoids, Biology, Chemistry, Medicine, 2nd Edn. Raven Press, New York, NY, pp. 573-595.
4. Russo, J., Gusterson, B.A., Rogers, A.E., Russo, I.H., Wellings, S.R. and Zwieten, M.J. (1990) Comparative study on human and rat mammary tumorigenesis. Lab. Invest., 62, 244-278.
5. Anderson, C.H., Hussain, R.A., Han, B.C. and Beattie, C.W. (1991) Estrous cycle dependence of nitrosomethylurea (MNU)-induced preneoplastic lesions in rat mammary gland. Cancer Lett., 56, 77-84.
6. Crist, K., Chaudhuri, B., Shivaram, S. and Chaudhuri, P.K. (1992) Ductal carcinoma in situ in rats mammary gland. J. Surg. Res., 52, 205-208.
7. Thompson, H.J., McGinley, J.N., Rothhammer, K. and Singh, M. (1995) Rapid inductions of mammary intraductal proliferations, ductal carcinoma in situ and carcinoma by the injection of sexually immature female rats with 1-methyl-1-nitrosourea. Carcinogenesis, 16, 2407-2411.
8. Thompson, H.J., McGinley, J., Rothhammer, K. and Singh, M. (1998) Ovarian hormone dependence of pre-malignant and malignant mammary gland lesions induced in prepubertal rats by 1-methyl-1-nitrosourea. Carcinogenesis, 19, 383-386.
9. Korkola, J.E. and Archer, M.C. (1999) Resistance to mammary tumorigenesis in Copenhagen rats is associated with the loss of preneoplastic lesions. Carcinogenesis, 20, 221-227.
10. Christov, K., Guzman, R., Thordarson, G., Talamantes, F. and Nandi, S. (1996) Cell proliferation and apoptosis during mammary carcinogenesis in pituitary isografted mice. Carcinogenesis, 17, 1741-1746.
11. Green, A., Shilkaitis, A. and Christov, K. (1999) 4-HPR selectively suppresses the development and progression of ductal hyperplastic lesions and CIS in mammary carcinogenesis. Carcinogenesis, 20, 1535-1540.
12. Bednarek, A., Shilkaitis, A., Green, A., Lubet, R., Kelloff, G., Christov, K. and Aldaz, M.C. (1999) Suppression of cell proliferation and telomerase activity in 4-(hydroxyphenyl)retinamidc-treated mammary tumors. Carcinogenesis, 20, 879-883.
13. Witty, J.P., Lempka, T., Coffey, R.J. Jr and Matrisian, L.M. (1995) Decreased tumor formation in 7,12-dimethylbenzanthracene-treated stromelysin-1 transgenic mice is associated with alterations in mammary epithelial cell apoptosis. Cancer Res., 55, 1401-1406.
14. Christov, K., Swanson, S.M, Guzman, R.C., Thordarson, G., Jin, E., Talamantes, F. and Nandi, S. (1993) Kinetics of mammary epithelial cell proliferation in pituitary isografted BALB/c mice. Carcinogenesis, 14, 2019-2025.
15. Russo, J., Russo, I.H., van Zwieten, M.J., Rogers, A.E. and Gusterson, B. (1989) Classification of neoplastic and non-neoplastic lesions of the rat mammary gland. In Jones, T.C, Mohr, U. and Hunt, R.D. (eds) Monographs on Pathology of Laboratory Animals: Integument and Mammary Glands. Springer Verlag, Berlin, Germany, pp. 275-340.
16. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S.A. (1992) Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119, 493-501.
17. Snedecor, G.J.W. and Cochran, W.G. (1989) Statistical Methods, 8th Edn. Iowa State University Press, Ames. IA, Ch. 11.
18. McCullagh, P. and Nelder, J.A. (1989) Generalized Linear Models. Chapman and Hall, London, Ch. 6.
19. Russo, J., Saby, J., Isenberg, W.M. and Russo, I. (1977) Pathogenesis of mammary carcinomas induced in rats by 7,12-dimethylbenz(a)nthracene. J. Natl Cancer Inst., 59, 435-445.
20. Beuving, L., Faulkin, L.J. Jr. DeOme, K.B. and Bergs, V.V. (1967) Hyperplastic lesions in the mammary gland of Sprague-Dawley rats after 7,12-dimethylbenz(a)anthracene treatment. J. Natl Cancer Inst., 39, 423-429.
21. Sinha, D.K. and Dao, T.L. (1975) Site of origin of mammary tumors induced by 7,12-dimethylnezanthrazene in the rat. J. Natl Cancer Inst., 54, 1007-1009.
22. Haslam, S.Z. and Bern, H.A. (1977) Histopatnogenesis of 7,12-dimethylbenz(a)anthrazene-induced rat mammary tumors. Proc. Natl Acad. Sci. USA, 74, 4020-4024.
23. Cardiff, R.D. and Munn, R.J. (1995) Comparative pathology of mammary tumorigenesis in transgenic mice. Cancer Lett., 90, 13-19.
24. Russo, J. and Russo, I.H. (1978) DNA labeling index and structure of the rat mammary gland as determinants of its susceptibility to carcinogenesis. J. Natl Cancel Inst., 61, 1451-1459.
25. Russo, J. and Russo, I. (1980) Influence of differentiation and cell kinetics on the susceptibility of the rat mammary gland to carcinogenesis. Cancer Res., 40, 2677-2687.
26. Anderson, C.H. and Bettie, C.W. (1992) Cellular kinetics of rat mammary gland terminal endbud epithelium exposed to N-methyl-N-nitrosoures in vivo, Cancer Res., 52, 5076-5081.
27. Osborn, M.P., Ruperto, J.F., Crowe, J.P., Rosen, P.P. and Telang, N.T. (1992) Effect of tamoxifen on preneoplastic cell proliferation in N-nitroso-N-methylurea-induced mammary carcinogenesis. Cancer Res., 52, 1477-1480.
28. Russo, I.H., Ireland, M., Isenberg, W. and Russo, J. (1976) Ultrastructural description of three different epithelial cell types in the rat mammary gland. Proc. Electron. Microsc. Soc. Am., 34, 146-147.
29. Russo, J., Isenberg, W., Ireland, M. and Russo, I.H. (1976) Ultrastructural changes in the mammary epithelial cell population during neoplastic development induced by a chemical carcinogen. Proc. Electron. Microsc. Soc. Am., 34, 250-251.
30. Humphreys, R.C., Krajewska, M., Krnacik, S., Jaeger, R., Weiher, H., Krajewski, S., Reed, J.C. and Rosen, J.M. (1996) Apoptosis in the terminal endbud of the murine mammary gland: a mechanism of ductal morphogenesis. Development, 122, 4013-4022.
31. Srivastava, P., Russo, J. and Russo, I.H. (1997) Chronic gonadotropin inhibits rat mammary carcinogenesis through activation of programmed cell death. Carcinogenesis, 18, 1797-1808.
32. Lund, L.R., Romer, J., Thomasset, N., Solberg, H., Pyke, C., Bissell, M., Dana, K. and Werb, Z. (1996) Two distinctive phases of apoptosis in mammary gland involution: proteinase-independent and -dependent pathways. Development, 122, 181-193.
33. Graeber, T.G., Osmanlan, C., Jacks, T., Housman, D., Koch, C.J., Lowe, S.W. and Glaccla, A.J. (1996) Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature, 379, 88-92.
34. Jacobson, M.D. and Raff, M.C. (1995) Programmed cell death and Bcl-2 protection in very low oxygen. Nature, 374, 814-816.
35. Bowen, I.D. and Bowen, S.M. (eds) (1990) Programmed Cell Death in Tumors and Tissues. Chapman and Hall, New York, NY.