Effect of rifaximin on intestinal bacterial overgrowth in Crohn's disease as assessed by the H2-glucose breath test

Current Medical Research and Opinion

Volumn 16, Issue 1, 2000, Pages 14-20

  Biancone, L ^a   Vernia, P ^a   Agostini, D ^a   Ferrieri, Antonella ^b   Pallone, F ^c  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b Alfa Wassermann SpA   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

Bacterial overgrowth; Common cold; Crohn's disease; H2 glucose breath test; Rifaximin

Indexed keywords

GLUCOSE; HYDROGEN; MESALAZINE; PLACEBO; RIFAMYCIN; RIFAXIMIN;

ADULT; ARTICLE; BACTEREMIA; BACTERIAL OVERGROWTH; CHRONOLOGY; CLINICAL ARTICLE; CLINICAL TRIAL; CROHN DISEASE; FEMALE; HUMAN; HYDROGEN BREATH TEST; ILEUM; INTESTINE FLORA; MALE; SINGLE BLIND PROCEDURE;

EID: 0033952195     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/0300799009117003     Document Type: Article

References (32)

1. Aluwihare, A. P. R. (1971). Electron microscopy in Crohn's disease. Gut, 12, 509-518.
2. Beeken, W. L. and Kanich, R. E. (1973). Microbial flora of the upper small bowel in Crohn's disease. Gastroenterology, 65, 390-397.
3. Bernstein, L. H., Frank, M. S., Brandt, L. J. and Boley, S. J. (1980). Healing of perianal Crohn's disease with metronidazole. Gastroenterology, 795, 357-365.
4. Best, W. R., Becktel, J. M., Singleton, J. W. and Keen, F. (1976). Development of a Crohn's disease activity index. Gastroenterology, 70, 785-787.
5. Burman, J. H., Thompson, H., Cooke, W. T. and Williams, J. A. (1979). The effects of diversion of intestinal contents on the progress of Crohn's disease of the large bowel. Gut, 11-15.
6. Chadwick, V. S. and Anderson, R. P. (1992). Microorganisms and their products in inflammatory bowel disease. In: McDermott, R. P. and Súmpson, W. F. (Eds), Inflammatory Bowel Disease, Elsevier, New York, 241-258.
7. Chadwick, V. S. (1992). Immunology of inflammatory bowel disase. Curr. Opin. Gastroenterol., 8, 634-640.
8. Corazza, G. R., Menozzi, M. G., Strocchi, A., Rasciti, L., Vaira, D., Lecchini, R., Avanzini, P., Chezzi, C. and Gasbarrini, G. (1990). The diagnosis of small bowel bacterial overgrowth. Gastroenterology, 98, 302-305.
9. Corazza, G. R., Menozzi, M. G. and Vaira, D. (1985). A simpler and more rapid approach to the diagnosis of small bowel bacterial overgrowth. Ital. J. Gastroenterol., 17, 182-188.
10. Corazza, G. R., Sorge, M., Strocchi, A., Benati, G., Di Sario, A., Treggiari, E. A., Brusco, G. and Gasbarrini, G. (1992). Non-absorbable antibiotics and small bowel bacterial overgrowth. Ital. J. Gastroenterol., 24 (Suppl 2), 4-9.
11. Descombe, J. J., Duburg, D., Picard, N. and Palazzini, E. (1994). Pharmacokinetic study of Rifaximine after oral administration in healthy volunteers. Int. J. Clin. Pharm. Res., 14, 51-56.
12. Elliot, P., Lennard-Jones, J. E., Burnham, W., White, R. and Stanford, J. E. (1980). Further data on skin testing with mycobacterial antigens in Crohn's disease. Lancet, ii, 483-484.
13. Fluorie, B., Turk, J., Lemann, M., Florent, C., Cohman, R. and Rambaud, J. C. (1989). Breath hydrogen in bacterial overgrowth. Gastroenterology, 98, 302-305.
14. Gilat, T., Ben Hur, H., Gelman-Malachi, E., Terdiman, R. and Peled, Y. (1978). Alterations of the colonic flora and their effect on the hydrogen breath test. Gut, 19, 602-603.
15. Gillis, J. C. and Brogden, R N. (1995). Rifaximin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic potential in conditions mediated by gastrointestinal bacteria. Drugs, 49, 467-484.
16. Graham, D. Y., Markesich, D. C. and Yoshimura, H. H. (1987). Mycobacteria and inflammatory bowel disease. Results of culture. Gastroenterology, 92, 436-442.
17. Hoover, W. W., Gerlach, E. H., Hoban, D. J., Elkiopoulos, G. M., Pfaller, M. A. and Jones, R. N. (1993). Antimicrobial activity and spectrun of rifaximin, a new topical rifamycin derivative. Diag. Microbiol. Infect. Dis., 16, 111-118.
18. Katz, K. D., Hollander, D., Vadheim, C. M., McElree, C., Delahunty, T., Dadufalza, V. D., Krugliak, P. and Rotter, J. I. (1989). Intestinal permeability in patients with Crohn's disease and their healthy relatives. Gastroenterology, 87, 927-931.
19. Mishina, D., Katsel, P., Brown, S. T., Gilberts, E. C. A. M. and Greenstein, R. J. (1996). On the ethiology of Crohn's disease. Proc. Natl. Acad. Sci., 93, 9816-9820.
20. Morson, B. C. and Dawson, I. M. P. (1977). Gastrointestinal Pathology. Blackwells, Oxford.
21. Pallone, F., Poirivant, M., Fais, S., Luzza, F., Doldo, P., Monteleone, G. and Aloi, A. (1992). Antibacterial drugs in Crohn's Disease. Ital. J. Gastroenterol., 24 (Suppl 2), 17-18.
22. Pallone, F., Ricci, F. and Iannoni, C. (1973). Quantitative study of the cell density of the lamina propria in the human rectum. Rendic. Gastroenterol., 5, 223-224.
23. Perman, J. A. (1991). Clinical application of breath hydrogen measurements. Can. J. Physiol. Pharmacol., 69, 111-115.
24. Prantera, C., Kohn, A., Zannoni, F., Spimpolo, N. and Bonfa, M. (1994). Metronidazole plus ciprofloxacin in ihe treatment of active refractory Crohn's disease: results of an open study. J. Clin. Gastroenterol. 19, 79-88.
25. Prizont, R., Hersh, T. and Floch, M. H. (1970). Jejunal bacterial flora in chronic small bowel disease. Am. J. Clin. Nutr., 23, 1602-1607.
26. Rutgeerts, P., Geboes, K., Elemans, J. and Vantrappen, G. (1991). Surgical diversion of fecal stream prevents post operative recurrence in Crohn's disease. Lancet, 1, 396-398.
27. Rutgeerts, P., Hiele, M., Geboes, K., Peeters, M., Penninckx, F., Aerts, R. and Kerremans, R. (1995). Controlled trial of metronidazole treatment for prevention of Crohn's recurrence after ileal resection. Gastroenterology, 108, 1617-1621.
28. Sartor, R. B. (1993). Antimicrobial therapy of inflammatory bowel disease: implications for pathogenesis and management. Can. J. Gastroenterol., 7, 132-138.
29. Sartor, R. B. (1994). Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology, 106, 533-539.
30. 2 production capacity. Gastroenterol. Int., 1 (Suppl 1), 593-594.
31. Ursing, B. and Kamme, G. (1975). Metronidazole for Crohn's disease. Lancet, i, 775-777.
32. Vince, A., Dyer, N. H., O'Grady, F. W. and Dawson, A. M. (1972). Bacteriological studies in Crohn's disease. J. Med. Microbiol., 5, 219-229.