Selection against frameshift mutations limits microsatellite expansion in coding DNA

Genome Research

Volumn 10, Issue 1, 2000, Pages 72-80

  Metzgar, David ^a   Bytof, Jeffrey ^a   Wills, Christopher ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DINUCLEOTIDE; FUNGAL DNA; MICROSATELLITE DNA; NUCLEOTIDE; PLANT DNA; REPETITIVE DNA; TRINUCLEOTIDE;

ARTICLE; CODON; EUKARYOTIC CELL; FRAMESHIFT MUTATION; FUNGAL GENETICS; GENE FREQUENCY; GENE MUTATION; GENETIC SELECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; DNA; DNA, BACTERIAL; DNA, FUNGAL; DNA, PLANT; FRAMESHIFT MUTATION; GENOMIC LIBRARY; MICROSATELLITE REPEATS; PRIMATES;

EUKARYOTA;

EID: 0033951367     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Bell, G.I. and J. Jurka. 1997. The length distribution of perfect dimer repetitive DNA is consistent with its evolution by an unbiased single-step mutation process. J. Mol. Evol. 44: 414-421.
2. Caskey, C.T., A. Pizzuti, Y.H. Fu, R.G. Fenwick and D.L. Nelson. 1992. Triplet repeat mutations in human disease. Science 256: 784-789.
3. Cox, R. and S.M. Mirkin. 1997. Characteristic enrichment of DNA repeats in different genomes. Proc. Natl. Acad. Sci. 94: 5237-5242.
4. deWachter, R. 1981. The number of repeats expected in random nucleic acid sequences and found in genes. J. Theor. Biol. 91: 71-98.
5. Field, D. and C. Wills. 1998. Abundant microsatellite polymorphism in Saccharomyces cerevisiae, and the different distributions of microsatellites in eight prokaryotes and S. cerevisiae, result from strong mutation pressures and a variety of selective forces. Proc. Natl. Acad. Sci. 95: 1647-1652.
6. Hancock, J.M. 1995. The contribution of slippage-like processes to genome evolution. J. Mol. Evol. 41: 1038-1047.
7. _. 1996. Simple sequences and the expanding genome. BioEssays 18: 421-425.
8. Hancock, J.M. and J.S. Armstrong. 1994. SIMPLE34: An improved and enhanced implementation for VAX and Sun computers of the SIMPLE algorithm for analysis of clustered repetitive motifs in nucleotide sequences. Comput. Appl. Biosci. 10: 67-70.
9. Henderson, S.T. and T.D. Petes. 1992. Instability of simple sequence DNA in Saccharomyces cerevisiae. Mol. Cell. Biol. 12: 2749-2757.
10. Kruglyak, S., R.T. Durrett, M.D. Schug, and C.F. Aquadro. 1998. Equilibrium distributions of microsatellite repeat length resulting from a balance between slippage events and point mutations. Proc. Natl. Acad. Sci. 95: 10774-10778.
11. Levinson, G. and G.A. Gutman. 1987. Slipped-strand mispairing: A major mechanism for DNA sequence evolution. Mol. Biol. Evol. 4: 203-221.
12. Pupko, T. and D. Graur. 1999. Evolution of microsatellites in the yeast Saccharomyces cerevisiae: Role of length and number of repeated units. J. Mol. Evol. 48: 313-316.
13. Slatkin, M. 1995. A measure of population subdivision based on microsatellite allele frequencies. Genetics 139: 457-462.
14. Tautz, D. and C. Schlotterer. 1994. Simple sequences. Curr. Opin. Genet. Dev. 4: 832-837.
15. Tautz, D., M. Trick, and G.A. Dover. 1986. Cryptic simplicity in DNA is a major source of genetic variation. Nature 322: 652-656.
16. Zar, J.H. 1984. Paired-sample testing by ranks (10.4). In Biostatistical analysis. (ed.) B. Kurtz pp. 153-156. Prentice-Hall, Englewood Cliffs, NJ.