Selective expression and constitutive phosphorylation of Src-homology-2 and collagen-homology domains proteins in the CD34+ fraction of chronic myelogenous leukemias

Cancer Research

Volumn 60, Issue 3, 2000, Pages 728-732

  Bonati, Antonio ^a   Carlo Stella, Carmelo ^a   Lunghi, Paolo ^a   Albertini, Roberto ^a   Pinelli, Silvana ^a   Migliaccio, Enrica ^b   Sammarelli, Gabriella ^a   Savoldo, Barbara ^a   Tabilio, Antonio ^c   Dall'Aglio, Pier Paolo ^a   Pelicci, Pier Giuseppe ^a,b  

^a UNIVERSITY OF PARMA   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; COLLAGEN; HYBRID PROTEIN; PROTEIN KINASE P60; PROTEIN TYROSINE KINASE; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR;

ARTICLE; BLAST TRANSFORMATION; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANTIGENS, CD34; BONE MARROW; GRANULOCYTE COLONY-STIMULATING FACTOR; HUMANS; LEUKEMIA, MYELOID, CHRONIC; PHOSPHORYLATION; PROTEINS; SRC HOMOLOGY DOMAINS;

EID: 0033950896     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Bonfini, L., Migliaccio, E., Pelicci, G., Lanfrancone, L., and Pelicci, P. G. Not all Shc's roads lead to Ras. Trends Biochem. Sci., 21: 257-261, 1996.
2. Pelicci, G., Lanfrancone, L., Grignani, F., McGlade, J., Cavallo, F., Forni, G., Nicoletti, I., Grignani, F., Pawson, T., and Pelicci, P. G. A novel transforming protein (SHC) with a SH2 domain is implicated in mitogenic signal transduction. Cell, 70: 93-104, 1992.
3. Lanfrancone, L., Pelicci, G., Brizzi, M. F., Casciari, C., Aronica, M. G., Giuli, S., Pegoraro, L., Pawson, T., and Pelicci, P. G. Overexpression of Shc proteins potentiates the proliferative response to the GM-CSF and recruitment of Grb2/Sos and Grb2/p140 complexes to the β-receptor subunit. Oncogene, 10: 907-917, 1995.
4. McGlade, J., Cheng, A., Pelicci, G., Pelicci, P. G., and Pawson, T. Shc proteins are phosphorylated and regulated by the v-src and v-fps protein tyrosine kinases. Proc. Natl. Acad. Sci. USA, 89: 8869-8873, 1992.
5. Rozakis-Adcock, M., McGlade, J., Mbamalu, G., Pelicci, G., Daly, R., Li, W., Batzer, A., Thomas, S., Brugge, J., Pelicci, P. G., Schlessinger, J., and Pawson, T. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinase. Nature (Lond.), 360: 689-692, 1992.
6. Egan, S. E., Giddings, B. W., Brooks, M. W., Buday, L., Sizeland, A. M., and Weinberg, R. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature (Lond.), 363: 45-51, 1993.
7. Salcini, A. E., McGlade, J., Pelicci, G., Nicoletti, I., Pawson, T., and Pelicci, P. G. Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins. Oncogene, 9: 2827-2836, 1994.
8. Pelicci, G., Lanfrancone, L., Salcini, A. E., Romano, A., Mele, S., Borrello, M. G., Segatto, O., Di Fiore, P. P., and Pelicci, P. G. Constitutive phosphorylation of Shc proteins in human tumors. Oncogene, 11: 899-907, 1995.
9. Jucker, M., Shiffer, C. A., and Feldman, R. A. A tyrosine-phosphorylated protein of 140 kD is constitutively associated with the phosphotyrosine binding domain of Shc and the SH3 domains of Grb2 in acute myeloid leukemia cells. Blood, 89: 2024-2035, 1997.
10. Shtivelman, E., Lifshitz, B., Gale, R. P., and Canaani, E. Fused transript of ABL and BCR genes in chronic myelogenous leukemia. Nature (Lond.), 315: 550-554, 1985.
11. Guo, J. Q., Wang, J. Y. J., and Arlinghaus, R. B. Detection of BCR-ABL proteins in blood cells of benign phase chronic myelogenous leukemia patients. Cancer Res., 51: 3048-3051, 1991.
12. Melo, J. V. The diversity of BCR/ABL fusion proteins and their relationship to leukemia phenotype. Blood, 88: 2375-2384, 1996.
13. Gotoh, A., and Broxmeyer, H. E. The function of BCR/ABL and related oncogenes. Curr. Opin. Hematol., 4: 3-11, 1997.
14. Matsuguchi, T., Salgia, R., Hallek, M., Eder, M., Druker, B., Erns, T. J., and Griffin, J. D. Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL. J. Biol. Chem, 269: 5016-5021,1994.
15. Tauchi, T., Boswell, H. S., Leibowitz, D., and Broxmeyer, H. E. Coupling between p210bcr-abl and Shc and Grb2 proteins in hematopoietic cells permitts growth factor receptor- independent link to Ras activation pathway. J. Exp. Med., 179: 167-175, 1994.
16. Okuda, K., Golub, T. R., Gilliland, D. G., and Griffin, J. D. p210BCR/ABL, p190BCR/ABL, and TEL/ABL activate similar signal transduction pathways in hematopoietic cell lines. Oncogene, 13: 1147-1152, 1996.
17. Goldman, J. M. Chronic myeloid leukemia. Curr. Opin. Hematol., 4: 277-285, 1997.
18. Fogli, M., Amabile, M., Martinelli, G., Fortuna, A., Rondelli, D., Ratta, M., Curti, A., Tura, S., and Lemoli, R. M. Selective expansion of normal haemopoietic progenitors from chronic myelogenous leukaemia marrow. Br. J. Haematol., 1011: 119-129, 1998.
19. Dazzi, F., Capelli, D., Hasserjian, R., Cotter, F., Corbo, M., Poletti, A., Chinswangwatanakul, W., Goldman, J. M., and Gordon, M. Y. The kinetics and extent of engraftment of chronic myelogenous leukemia cells in non-obese diabetic/severe combined immunodeficiency mice reflect the phase of the donor's disease: an in vivo model of chronic myelogenous leukemia biology. Blood, 92: 1390-1396, 1998.
20. Migliaccio, E., Mele, S., Salcini, A. E., Pelicci, G., Venus Lai, K-M., Superti-Furga, G., Pawson, T., Di Fiore, P. P., Lanfrancone, L., and Pelicci, P. G. Opposite effects of the p52shc/p46 she and p66 she splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway. EMBO J., 16: 706-716, 1997.
21. Donaldson, R. W., and Cohen, S. Epidermal growth factor stimulates tyrosine phosphorylation in the neonatal mouse: association of a M(r) 55,000 substrate with the receptor. Proc. Natl. Acad. Sci. USA, 89: 8477-8481, 1992.
22. Lotti, L. V., Lanfrancone, L., Migliaccio, E., Zompetta, C., Pelicci, G., Salcini, A. E., Pelicci, P. G., and Torrisi, M. R. Shc proteins are localized on endoplasmic reticulum membranes and are redistributed following tyrosine kinase receptor activation. Mol. Cell. Biol., 16: 1946-1954, 1996.
23. Conti, L., De Fraia, C., Gulisano, M., Migliaccio, E., Govoni, S, and Cattaneo, E. Expression and activation of SH2/PTB-containing ShcA adaptor protein reflects the pattern of neurogenesis in the mammalian brain. Proc. Natl. Acad. Sci. USA, 94: 8185-8190, 1997.