Identification and clearance involved in the formation of glucuronides of RT-3003, a new peripheral blood flow enhancer, and its metabolite in rats

Biological and Pharmaceutical Bulletin

Volumn 23, Issue 1, 2000, Pages 128-131

  Kaburagi, Takayuki ^a   Yoshitsugu, Hiroyuki ^b   Uekusa, Harumi ^a   Ishibashi, Masataka ^b   Nanbo, Toshio ^a  

^a Institute of Xenobiotic Analyses   (Japan)

^b Takata Seiyaku Co Ltd   (Japan)

Author keywords

Clearance; Glucuronidation site; Liquid chromatography (LC) MS MS; Nuclear Overhauser effect

Indexed keywords

1BETA ETHYL 1 ALPHA HYDROXYMETHYL 1,2,3,4,6,7,12BA OCTAHYDROINDORO [2,3 A] QUINOLIZINE; GLUCURONIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD FLOW; CHEMICAL STRUCTURE; DRUG CLEARANCE; ENZYME ACTIVITY; GLUCURONIDATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; NONHUMAN; RAT;

EID: 0033949963     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.23.128     Document Type: Article

References (5)

1. Szombathelyi Z., Karpati E., Kalaus G., Szabo L., Szantay C., Arzneim.-Forsch., 41, 621-625 (1991).
2. Nanbo T., J. Pharmacobio-Dyn., 5, 849-852 (1982).
3. Nanho T., J. Pharmacobio-Dyn., 5, 213-221 (1982).
4. Staraub K. M., "Mass Spectrometry in Biomedical Research," ed. by Gaskell S. J., John Wiley & Sons, Chichester, 1986, pp. 115-134.
5. Leo A., Jow P. Y., Silipo C., Hansh C., J. Med. Chem., 18, 865-868 (1975).