Gallyas-positive argyrophilic and ubiquitinated filamentous inclusions in rapidly progressive motor neuron disease: Immunohistochemical and electron microscopic studies

Acta Neuropathologica

Volumn 100, Issue 2, 2000, Pages 221-227

  Katayama, Sadao ^a   Watanabe, Chigusa ^b   Kohriyama, Tatsuo ^a   Yamamura, Yasuhiro ^a   Mao, Jin Jie ^a   Ohishi, Hitoshi ^a   Nishisaka, Takashi ^a   Inai, Kouki ^a   Tanaka, Eiji ^a   Nakamura, Shigenobu ^a  

^a HIROSHIMA UNIV SCHOOL OF MEDICINE   (Japan)

^b Department of Neurology   (Japan)

Author keywords

Argyrophilic and ubiquitinated filamentous inclusions; Modified Gallyas Braak methods; Rapidly progressive motor neuron disease; Tubular like filamentous profiles

Indexed keywords

UBIQUITIN;

AGED; ARGYROPHILIA; ARTICLE; AUTOPSY; CASE REPORT; CELL INCLUSION; CELL LOSS; CLINICAL FEATURE; CUNEATE NUCLEUS; DISEASE COURSE; ELECTRON MICROSCOPY; FEMALE; GLIOSIS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEWY BODY; MOTONEURON; MOTOR NEURON DISEASE; MUSCLE WEAKNESS; NERVE CELL; NEUROPATHOLOGY; OCULOMOTOR NUCLEUS; PERIKARYON; PRIORITY JOURNAL; SPINAL CORD DORSAL HORN; SPINAL CORD VENTRAL HORN; SPINOCEREBELLAR TRACT;

EID: 0033949936     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004019900156     Document Type: Article

References (19)

1. Ciechanover A (1993) The ubiquitin-mediated proteolytic pathway. Brain 3 : 67-75
2. Doherty FJ, Osborn NV, Wasell JA, Heggie PE, Laszlo L, Mayer RJ (1989) Ubiquitin-protein conjugates accumulate in the lysosomal system of fibroblasts treated with cysteine protease inhibitors. Biochem J 263 : 47-55
3. Guiroy DC, Mellini M, Miyazaki M, Hillbich C, Safar J, Garrulo RM, Yanagihara R, Beyreuther K, Gajdusek DC (1993) Neurofibrillary tangles of Guamanian amyotrophic lateral sclerosis, parkinsonism-dementia and neurologically normal Guamanian contain a 4-to 4.5-kilodalton protein which is immunoreactive to anti-amyloid β/A4-protein antibodies. Acta Neuropathol 86 : 265-274
4. Hirano A, Kurland LT, Sayre GP (1967) Familial amyotrophic lateral sclerosis: a subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior cells. Arch Neurol 16 : 232-243
5. Jellinger KA (1998) Dementia with grains (argyrophilic grain disease). Brain Pathol 8 : 377-386
6. Kato S, Hirano A, Llena JF, Ito H, Yen SH (1992) Ultrastructural identification of neurofibrillary tangles in the spinal cords in Guamanian amyotrophic lateral sclerosis and parkinson-dementia complex on Guam. Acta Neuropathol 83 : 277-282
7. Kato T, Hirano A, Weinberg MN, Jacob AK (1986) Spinal cord lesions in progressive supranuclear palsy: some new observations. Acta Neuropathol (Berl) 71 : 11-14
8. Leigh PN, Anderson BH, Dodson A, Gallo JM, Swash M, Power DM (1988) Ubiquitin deposits in anterior horn cells in motor neuron disease. Neurosci Lett 93 : 197-203
9. Leigh PN, Whitwell H, Garofalo O, Buller J, Swash M, Martin JE, Gallo JM, Weller RO, Anderton BH (1991) Ubiquitin-immunoreaclive intraneuronal inclusions in amyotrophic lateral sclerosis. Brain 114 : 775-788
10. Lowe J, Lennox G, Jefferson D, Morrell K, McQuire D, Gray T, Landon M, Doherty FJ, Mayer RJ (1988) A filamentous inclusion body within anterior horn neurons in motor neuron disease defined by immunohistocytochemical localization of ubiquitin. Neurosci Lett 94 : 203-210
11. Matsumoto S, Kusaka H, Murakami N, Hashizume Y, Okazaki H, Hirano A (1992) Basophilic inclusions in sporadic juvenile amyotrophic lateral sclerosis: an immunocytochemical and ultrastructural study. Acta Neuropathol 83 : 579-583
12. Mizusawa H, Nakamura H, Wakayama I, Yen S-HC, Hirano A (1991) Skein-like inclusions in the anterior horn cells in motor neuron disease. J Neurol Sci 105 : 14-21
13. Murayama S, Mori H, Ihara Y, Bouldin TW, Suzuki K, Tomonaga M (1990) Immunohistochemical and ultrastructural studies of lower motor neurons in amyotrophic lateral sclerosis. Ann Neurol 27 : 137-148
14. Oda M, Akagawa N, Tabuchi Y, Tanabe H (1978) A sporadic juvenile case of the amyotrophic lateral sclerosis with neuronal intracytoplasmic inclusions. Acta Neuropathol (Berl) 44 : 211-216
15. Rechsteiner M (1987) Ubiquitin-medialed pathways for intracellular proteolysis. Annu Rev Cell Biol 3 : 1-30
16. Sasaki S, Maruyama S (1992) Ultrastructural study of skein-like inclusions in anterior horn neurons of patients with motor neuron disease. Neurosci Lett 147 : 121-124
17. Shankar SK, Yanagihara R, Garruto RM, Grundke-Iqbal I, Kosik KS, Gajdusek DC (1989) Immunohistochemical characterization of neurofibrillary tangles in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam. Ann Neurol 25 : 146-151
18. Umahara T, Hirano A, Kato S, Shibata N, Yen SH (1994) Demonstration of neurofibrillary tangle and neuropil thread-like structures in spinal cord white matter in parkinson-dementia complex on Guam and in Guamanian amyotrophic lateral sclerosis. Acta Neuropathol 88 : 180-184
19. Wohlfart G, Swank RL (1941) Pathology of amyotrophic lateral sclerosis. Fiber analysis of the ventral roots and pyramidal tracts of the spinal cord. Arch Neurol Psychiatry 46 : 783-799