Long-term cardiovascular effects of high 'osteoprotective' dose levels of 17β-estradiol in spontaneously hypertensive rats

Cardiovascular Drugs and Therapy

Volumn 14, Issue 3, 2000, Pages 303-307

  Blacher, Jacques ^a   Dabire, Hubert ^a   Pomies, Jean P ^a   Safar, Michel E ^a   Stimpel, Michael ^b  

^a HÔPITAL BROUSSAIS   (France)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Arterial stiffness; Estrogens; Female spontaneously hypertensive rats

Indexed keywords

COLLAGEN; ELASTIN; ESTRADIOL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA WALL; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; FEMALE; MORPHOMETRICS; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; THORACIC AORTA;

ANIMALS; AORTA, THORACIC; BLOOD PRESSURE; BODY WEIGHT; ELASTIN; ESTRADIOL; EXTRACELLULAR MATRIX; FEMALE; HEMODYNAMIC PROCESSES; HORMONE REPLACEMENT THERAPY; MYOCARDIUM; OSTEOPOROSIS; OVARIECTOMY; RATS; RATS, INBRED SHR;

EID: 0033948708     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007834708642     Document Type: Article

References (31)

1. 1. Barret-Connor E, Bush TL. Estrogens and coronary heart disease. JAMA 1991;265:1851-1867.
2. 2. Grodstein F, Stampfer MJ, Manson JE, et al. Postmenopausal estrogen and progestin use and the risk of cardiovascular disease. N Engl J Med 1996;335:453-461.
3. 3. American College of Physicians. Guidelines for counselling postmenauposal women about preventive hormone therapy. Ann Intern Med 1992;117:1038-1041.
4. 4. Hillard TC, Whiteroft SJ, Marsh MS, et al. Long-term effects of transdermal and oral hormone replacement therapy on postmenopausal bone loss. Osteoporos Int 1994;4:341-348.
5. 5. Eiken P, Kolthoff N, Nielsen SP. Effect of 10 years' hormone replacement therapy on bone mineral content in postmenopausal women. Bone 1996;19(5 Suppl):S191-S193.
6. 6. Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA, 1998;280:605-613.
7. 7. Stimpel M, Jee WSS, Ma Y, Yamamoto N, Chen Y. Impact of antihypertensive therapy on postmenauposal osteoporosis: Effects of the angiotensin converting enzyme inhibitor moexipril, 17-β-estradiol and their combination on the ovariectomy-induced cancellous bone loss in young rats. J Hypertens 1995;13:1852-1856.
8. 8. Ma Y, Stimpel M, Linag H, Pun S, Jee WSS. Impact of antihypertensive therapy on the skeleton: Effects of moexipril and hydrochlorothiazide on osteopenia in spontaneously hypertensive ovariectomized rats. J Endocrinol 1997;154:467-474.
9. 9. Cox RH, Fischer GM. Effects of sex hormones on the passive mechanical properties of rat carotid artery. Blood Vessels 1978;15:266-276.
10. 10. Cox RH. Effects of age on the mechanical properties of rat carotid artery. Am J Physiol 1977;233:H256-H263.
11. 11. Fischer GM, Swain ML. In vivo effects of sex hormones on aortic elastin and collagen dynamics in castrated and intact male rats. Endocrinology 1978;102:92-97.
12. 12. Blackard CE, Doe RP, Mellinger GT, Byar DP. Incidence of cardiovascular disease and death in patients receiving diethylstilbestrol for carcinoma of the prostate. Cancer 1970;26:249-256.
13. 13. The Coronary Drug Project Research Group. The coronary drug project: Initial findings leading to modifications of its research protocol. JAMA 1970;214:1303-1313.
14. 14. Albaladejo P, Bouaziz H, Duriez M, et al. Angiotensin converting enzyme inhibition prevents the increase in aortic collagen in rats. Hypertension 1994;23:74-82.
15. 15. Kratky RG, Lo DK, Roach MR. Quantitative measurement of fixation rate and dimension changes in the aldehyde/pressure fixed canine carotid artery. Blood Vessels 1991;28:386-395.
16. 16. Partovian C, Benetos A, Pommies JP, Safar ME. Effects of a chronic high-salt diet on large artery structure: Role of endogenous bradykinin. Am J Physiol 1998;274:H1423-H1428.
17. 17. Fischer GM, Swain LM. Effect of sex hormones on blood pressure and vascular connective tissue in castrated and noncastrated male rats. Am J Physiol 1977;232:H617-H621.
18. 18. Calhoun DA, Zhu S-T, Cheny F, Oparil S. Gender and dietary NaCl in spontaneously hypertensive and Wistar-Kyoto rats. Hypertension 1995;26:285-289.
19. 19. Iams SG, Wexler BC. Inhibition of the development of spontaneous hypertension in SH rats by gonadectomy or estradiol. J Lab Clin Med 1979;94:608-616.
20. 20. Eiff AWV, Lutz H-M, Cries J, Kretzschmar R. The protective mechanism of estrogen on high blood pressure. Basic Res Cardiol 1985;80:191-201.
21. 21. Dahl LK, Knudsen KD, Ohanian EV, Muirhead M, Tuthill R. Role of the gonads in hypertension-prone rats. J Exp Med 1975;142:748-759.
22. 22. Cambotti LJ, Cole FE, Gerall AA, Frohlich ED, MacPhee AA. Neonatal gonadal hormones and blood pressure in the spontaneously hypertensive rat. Am J Physiol 1984;247:E258-E264.
23. 23. Crofton JT, Share L, Brooks DP. Gonadectomy abolishes the sexual dimorphism in DOC-salt hypertension in the rat. Clin and Exper Hyper - Theory Pract 1989;A11:1249-1261.
24. 24. Hoeg JM, Willis LR, Weinberger MH. Estrogen attenuation of the development of hypertension in spontaneously hypertensive rats. Am J Physiol 1977;233:H369-H373.
25. 25. Ouchi Y, Share L, Crofton JT, Itake K, Brooks DP. Sex difference in the development of deoxycorticosterone-salt hypertension in the rat. Hypertension 1987;9:172-177.
26. 26. Lew GM. Changes in blood pressure and norepinephrine concentration following administration of estrogens to genetically hypertensive and normotensive rats. Gen Pharmac 1975;6:121-125.
27. 27. Fischer GM, Swain ML. Influence of contraceptive and other sex thyroids on aortic collagen and elastin. Exp Mol Pathol 1980;33:15-24.
28. 28. Mendelsohn ME, Karas RH. Estrogen and the blood vessel wall. Cur Opin Cardiol 1994;9:619-626.
29. 29. Guetta V, Quyyumi AA, Prasad A, Panza JA, Waclawiw M, Cannon III RO. The role of nitric oxide in coronary vascular effects of estrogen in postmenopausal women. Circulation 1997;96:2795-2801.
30. 30. Somjen D, Kohen F, Jaffe A, Amir-Za Itsman Y, Knoll E, Stern N. Effect of gonadal steroids and their antagonists on DNA synthesis in human vascular cells. Hypertension 1998;32:39-45.
31. 31. Dai-Do D, Espinosa E, Liu G, et al. 17 beta-estradiol inhibits proliferation and migration of human vascular smooth muscle cells: similar effects in cells from postmenopausal females and in males. Cardiovasc Res 1996;32:980-985.