Coincident microvillar actin bundle disruption and perinuclear actin sequestration in anoxic proximal tubule

American Journal of Physiology - Renal Physiology

Volumn 278, Issue 6 47-6, 2000, Pages

  White, Peter ^a   Doctor, R Brian ^b   Dahl, Rolf H ^b   Chen, Jing ^a  

^a INDIANA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

ATP depletion; Cytoskeleton; Ischemia; Kidney; Villin

Indexed keywords

F ACTIN; VILLIN;

ANIMAL CELL; ANOXIA; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; KIDNEY ISCHEMIA; KIDNEY PROXIMAL TUBULE; MICROVILLUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RABBIT;

EID: 0033948524     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.2000.278.6.f886     Document Type: Article

References (22)

1. Bacallao R, Garfinkel A, Monke S, Zampighi G, and Mandel LJ. ATP depletion: a novel method to study junctional properties in epithelial tissues. I. Rearrangement of the actin cytoskeleton. J Cell Sci 107: 3301-3313, 1994.
2. Bretscher A and Weber K. Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner. Cell 20: 839-847, 1980.
3. Chen J, Doctor RB, and Mandel LJ. Cytoskeletal dissociation of ezrin during renal anoxia: role in microvillar injury. Am J Physiol Cell Physiol 267: C784-C795, 1994.
4. Chen J, Dai J, Grant RL, Doctor RB, Sheetz MP, and Mandel LJ. Loss of cytoskeletal support is not sufficient for anoxic plasma membrane disruption. Am J Physiol Cell Physiol 272: C1319-C1328, 1997.
5. Chen J, Cohn JA, and Mandel LJ. Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury. Proc Natl Acad Sci USA 92: 7495-7499, 1995.
6. Chen J and Mandel LJ. Unopposed phosphatase action initiates ezrin dysfunction in renal cells: a potential mechanism for anoxic injury. Am J Physiol Cell Physiol 273: C710-C716, 1997.
7. Dickman KG and Mandel LJ. Glycolytic and oxidative metabolism in primary renal proximal tubule cultures. Am J Physiol Cell Physiol 257: C333-C340, 1989.
8. Doctor RB, Zhelev D, and Mandel LJ. Loss of plasma membrane structural support in ATP-depleted renal epithelia. Am J Physiol Cell Physiol 272: C439-C449, 1997.
9. Doctor RB, Dahl RH, Salter KD, and Fitz JG. Reorganization of cholangiocyte membrane domains represents an early event in rat liver ischemia. Hepatology 29: 1364-1374, 1999.
10. Glaumann B, Glaumann H, Berezesky IK, and Trump BF. Studies on the pathogenesis of ischemic cell injury. II. Morphological changes of the P1 and P2 of the proximal tubule of the rat kidney made ischemic in vivo. Virchows Arch 19: 281-302, 1975.
11. Golenhofen N, Doctor RB, Bacallao R, and Mandel LJ. Actin and villin compartmentation during ATP depletion and recovery in renal cultured cells. Kidney Int 48: 1837-1845, 1995.
12. Heacock C and Banburg JR. The quantitation of G- and F-actin in cultured cells. Anal Biochem 135: 22-36, 1983.
13. Hesterberg LK and Weber K. Isolation of a domain of villin retaining calcium-dependent interaction with G-actin, but devoid of F-actin fragmenting activity. Eur J Biochem 154: 135-140, 1986.
14. Kellerman PS, Clark RA, Hoilien CA, Linas SL, and Molitoris BA. Role of microfilaments in maintenance of proximal tubule structural and functional integrity. Am J Physiol Renal Fluid Electrolyte Physiol 259: F279-F285, 1990.
15. Molitoris BA and Nelson WJ. Alterations in the establishment and maintenance of epithelial cell polarity as a basis for disease processes. J Clin Invest 85: 3-9, 1990.
16. Molitoris BA, Atkinson S, Hosford M, and Sandoval R. Mechanism of actin polymerization during ATP depletion in LLC-PK1 cells (Abstract). J Am Soc Nephrol 7: 1830, 1996.
17. Molitoris BA, Dahl R, and Hosford M. Cellular ATP depletion induces disruption of the spectrin cytoskeletal network. Am J Physiol Renal Fluid Electrolyte Physiol 271: F790-F798, 1996.
18. Nurko S, Sogabe K, Davis JA, Roeser NF, Defrain M, Chien A, Hinshaw D, Athey B, Meixner W, Venkatachalam MA, and Weinberg JM. Contribution of actin cytoskeletal alterations to ATP depletion and calcium-induced proximal tubule cell injury. Am J Physiol Renal Fluid Electrolyte Physiol 270: F39-F52, 1996.
19. Ramsby ML, Makowski GS, and Khairallah EA. Differential detergent fractionation of isolated hepatocytes: biochemical, immunochemical and two-dimensional gel electrophoresis characterization of cytoskeletal and noncytoskeletal compartments. Electrophoresis 15: 265-277, 1994.
20. Schwartz ND, Hosford M, Sandoval R, and Molitoris BA. Actin depolymerizing factor mediates proximal tubule cell apical microfilament disruption during ischemia (Abstract). J Am Soc Nephrol 8: 59, 1997.
21. Venkatachalam MA, Bernard DB, Donohoe JG, and Levinsky NG. Ischemic damage and repair in the rat proximal tubule: differences among the S1, S2, and S3 segments. Kidney Int 14: 31-49, 1978.
22. 1 cells. Am J Physiol Cell Physiol 272: C1680-C1690, 1997.