Androgenic adult granulosa cell tumor in a 13-year-old prepubertal patient: A case report and review of the literature

International Journal of Gynecological Pathology

Volumn 19, Issue 3, 2000, Pages 266-271

  Castro, Claudia V ^a   Malpica, Anais ^a   Hearne, Ronald H ^b   Silva, Elvio G ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b Nacogdoches Medical Specialties   (United States)

Author keywords

Adult granulosa cell tumor; Androgens; Children; Granulosa cell tumor; Ovarian neoplasms; Ovarian tumors; Pathology; Prepubertal; Testosterone; Virilization

Indexed keywords

HYDROXYPROGESTERONE; TESTOSTERONE;

ARTICLE; CASE REPORT; CLINICAL FEATURE; ENDOCRINE TUMOR; FEMALE; GRANULOSA CELL TUMOR; HISTOPATHOLOGY; HUMAN; POSTOPERATIVE PERIOD; PREPUBERTY; PRIORITY JOURNAL; SCHOOL CHILD; TESTOSTERONE BLOOD LEVEL; TUMOR VOLUME;

EID: 0033946631     PISSN: 02771691     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004347-200007000-00011     Document Type: Article

References (27)

1. Scully RE, Young RH, Clement PB. Tumors of ovary, maldeveloped gonads, fallopian tube and broad ligament. In: Atlas of Tumor Pathology. Washington, DC: Armed Forces Institute of Pathology, 1996:169-87.
2. Young RH, Scully RE. Ovarian sex cord-stromal tumors: recent progress. Int J Gynecol Pathol 1982;1:101-23.
3. Robinson MR. Primary and secondary ovarian cancer. A histogenetic, morphological, and clinical study. Surg Gynecol Obstet 1930;51:321-44.
4. Josefson A, Fagerstrom E, Bergstrand H. Two cases of hirsutism (virilism) with ovarian tumors. Acta Med Scand 1932;77:485-501.
5. Traut HF, Marchetti AA. A consideration of so-called "granulosa" and "theca" cell tumors of the ovary. Surg Gynecol Obstet 1940; 70:632-43.
6. Alexander WS, Beresford OD. Masculinization of ovarian origin: report of a case with virilization developing during pregnancy. J Obstet Gynaecol Emp 1953;60:252-8.
7. Mills IH, Brooks RV. Hirsutism associated with a testosterone-producing ovarian cyst. Proc R Soc Med 1959;52:1051-2.
8. Betson J, Marshall R, Chiffelle T. Scleropolycystic (Stein-Leventhal) ovary with an arrhenoblastoma of the opposite gonad. Am J Obstet Gynecol 1962;83:93-100.
9. Norris HJ, Taylor HB. Virilization associated with cystic granulosa cell tumors. Obstet Gynecol 1969;34:629-35.
10. Fox H, Agrawal K, Langley FA. A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. Cancer 1975;35:231-41.
11. Giuntoli RL, Celebre JA, Wu CH, Wheeler JE, Mikuta JJ. Androgenic function of a granulosa cell tumor. Obstet Gvnecol 1976;47: 77-9.
12. Wilansky DL, Scott BH, LaChance RC. Masculinizing granulosa cell tumor. Can Med Assoc J 1976;115:545-6.
13. Hatjis CG, Polin JI, Wheeler JE, Hayes JM. Amenorrhea-galactorrhea associated with a testosterone-producing, solid granulosa cell tumor. Am J Obstet Gynecol 1978;131:226-7.
14. Wilson SJ, Young BK, Katz M, Kammerman S, Epstein J, Bigelow B. A gonadotropin-responsive virilizing granulosa tumor. Diagn Gynecol Obstet 1980;2:275-81.
15. Lack EE, Perez-Atayde AR, Murthy ASK, Goldstein DP, Crigler JF, Vawter GF. Granulosa theca cell tumors in premenarchal girls: a clinical and pathologic study of ten cases. Cancer 1981;48: 1846-54.
16. Taylor HC, Velasco ME, Flores SG, Berg G, Brown TR. Amenorrhea and failure to virilize in a patient with a testosterone secreting granulosa cell tumor. Clin Endocrinol 1982;16:557-67.
17. Takeuchi H, Hamada H, Sodemoto Y, Ushigome S. Juvenile granulosa cell tumor associated with rapid distant metastases. Acta Pathol Jpn 1983;33:537-45.
18. Jarabak J, Talerman A. Virilization due to a metastasizing granulosa cell tumor. Int J Gynecol Pathol 1983;2:316-24.
19. Nakashima N, Young RH, Scully RE. Androgenic granulosa cell tumors of the ovary. A clinicopathologic analysis of 17 cases and review of the literature. Arch Pathol Lab Med 1984;108:786-91.
20. Dhom M, Duvivier P, Vandekerckhove B. A solid virilizing granulosa cell tumor. Eur J Obstet Gynecol Reprod Biol 1985;20: 253-6.
21. Betta P, Bellingeri D. Androgenic juvenile granulosa cell tumour. Eur J Gynaecol Oncol 1985;6:71-1.
22. Biscotti CV, Hart WR. Juvenile granulosa cell tumors of the ovary. Arch Pathol Lab Med 1989;113:40-6.
23. Zaydon C, Bogaars HA, Tucci JR. Virilizing granulosa cell tumor responsive to human chorionic gonadotropin and oral contraceptive with 8-year follow-up. Int J Gynecol Obstet 1989;29: 87-90.
24. Francois Y, Berlier P, Chatelain P, Francois R. Tumeur virilizante de l'ovaire chez une adolescente. Pediatrie 1990;45:105-7.
25. Caron PH, Cogne M, Rumeau JL, Hoff J. Androgenic granulosa cell tumor of the ovary: in vivo hormonal studies. J Endocrinol Invest 1993;16:545-8.
26. Martinez L, Salmeron M, Carvia RE, Campello TR, Molina R, Herruzo AJ, Nogales FF. Androgen producing luteinized granulosa cell tumor. Acta Obstet Gynecol Scand 1997;76:285-6.
27. Cronje HS, Niemand I, Bam RH, Woodruff JD. Granulosa and theca cell tumors in children: a report of 17 cases and literature review. Obstet Gynecol Surv 1998;53: 240-7.