Transforming growth factor-alpha, epidermal growth factor receptor, and PCNA immunoexpression in uterine leiomyosarcomas and leiomyomas in B6C3F1 mice

Experimental and Toxicologic Pathology

Volumn 52, Issue 3, 2000, Pages 195-200

  Moore, Alicia B ^a   He, Hong ^a   Yoshida, Akiyoshi ^a   Rico, Pedro J ^b   Haseman, Joseph K ^a   Dixon, Darlene ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Cell proliferation; Epidermal growth factor receptor; Growth factors; Immunoexpression; PCNA; Proliferating cell nuclear antigen; Transforming growth factor alpha; Uterine leiomyoma, leiomyosarcoma

Indexed keywords

CYCLINE; DESMIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ANIMAL TISSUE; ARTICLE; CELL DIVISION; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE MARKER; IMMUNOHISTOCHEMISTRY; LEIOMYOMA; LEIOMYOSARCOMA; MESENCHYMOMA; MOUSE; MYOMETRIUM; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; UTERUS TUMOR;

ANIMALIA; MURINAE; RODENTIA;

EID: 0033946166     PISSN: 09402993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0940-2993(00)80028-7     Document Type: Article

References (34)

1. AOYAMA H, KATO H, DIXON D: Specificity of antibodies against rodent transforming growth factor-alpha protein. J Histochem Cytochem 1997; 45: 696-701.
2. BRAVO , FRANK R, BLUNDELL PA, et al.: Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ. Nature 1987; 326: 515-517.
3. BUTTRAM VC, REITER RC: Uterine leiomyomata: Etiology, symptomatology, and management. Fertil Steril 1981; 36; 433-145.
4. COFFEY Jr RJ, DERYNCK R, WILCOX JN: Production and auto-induction of transforming growth factor-α in human keratinocytes. Nature 1987; 328: 817-820.
5. CRUM CP: The Female Genital Tract. In: COTRAN RS, KUMAR V, ROBBINS SL (Eds): Pathologic Basis of Disease. Philadelphia WB Saunders 1994 pp. 1033-1088.
6. DERYNCK R, ROBERTS AB, WINKLER ME, et al.: Human transforming growth factor-α: precursor structure and expression in E. coli Cell 1984; 38: 287-297.
7. DERYNCK R: Transforming growth factor α. Cell 1988; 54: 593-595.
8. DICKSON RB, KASID A, HUFF KK, et al.: Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17β-estradiol or v-Ha-ras oncogene. Proc Natl Acad Sci USA 1987; 84: 837-841.
9. GREENWELL A, FOLEY JF, MARONPOT RR: An enhancement method for immunohistochemical staining of proliferating cell nuclear antigen in archival rodent tissues. Cancer Letters 1991; 59: 251-256.
10. HAN VKM, HUNTER III ES, PRATT RM, et al.: Expression of rat transforming growth factor alpha mRNA during development occurs predominantly in the maternal decidua. Mol Cell Biol 1987; 7: 2335-2343.
11. HEYWOOD R, WADSWORTH PF: The experimental toxicology of estrogens In: CHAUDHURY RR (ed): Pharmacology of Estrogens. Elmsford Pergamon Press 1981 pp. 63-80.
12. JAKOWLEW SB, KONDAIAH P, FLANDERS KC, et al.: Increased expression of growth factor mRNAs accompanies viral transformation of rodent cells. Oncogene Res 1988; 2: 135-148.
13. KURKI P, VANDERLAAN M, DOLBEARE F, et al.: Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell-cycle. Exp Cell Res 1986; 166: 209-219.
14. LEE DC, ROSE TM, WEBB NR: Cloning and sequence analysis of a cDNA for rat transforming growth factor-α. Nature 1985; 313: 489-491.
15. LEE G-H, MERLINO G, FAUSTO N: Development of liver tumors in transforming growth factor-α transgenic mice. Can Res 1992; 52: 5162-5170.
16. LIU SC, SANFILIPPO B, PERROTEAU I, et al.: Expression of transforming growth factor-α (TGF-α) in differentiated rat mammary tumors: estrogen induction of TGF-α production. Mol Endocrinol 1987; 1: 683-692.
17. LUMSDEN MA: The role of oestrogen and growth factors in the control of the growth of uterine leiomyomata. In: SHAW RW (ed): Uterine Fibroids: Time for Review. Park Ridge Pathenon Publishing Group 1992 Vol 4. pp. 9-20.
18. MILLER RG Jr: Simultaneous statistical inference. New York, McGraw-Hill 1966 pp. 90-94.
19. NICKELL KA, HALPER J, MOSES HL: Transforming growth factors in solid human malignant neoplasms. Can Res 1983; 43: 1966-1971.
20. NORSTEDT G, LEVINOVITZ A, ERIKSSON H: Regulation of uterine insulin-like growth factor I mRNA and insulin-like growth factor II mRNA by estrogen in the rat. Acta Endocrinologica 1989; 120: 466-472.
21. PRIGENT SA, LEMOINE NR: The type 1 (EGFR-related) family of growth factor receptors and their ligands. Prog Growth Factor Res 1992; 4: 1-24.
22. REYNOLDS Jr FH, TODARO GJ, FRYLING C: Human transforming growth factors induce tyrosine phosphorylation of EGF receptors. Nature 1981; 292: 259-262.
23. ROSENTHAL A, LINDQUIST PB, BRINGMAN TS, et al.: Expression in rat fibroblasts of a human transforming growth factor-α cDNA results in transformation. Cell 1986; 46: 301-309.
24. SKINNER MK, TAKACS K, COFFEY RJ: Transforming growth factor-α gene expression and action in the seminiferous tubule: peritubular cell-sertoli cell interactions. Endocrinology 1989; 124: 845-854.
25. SNEDECOR GW, COCHRAN WG: Statistical methods. Ames, Iowa State University Press 1980 pp. 291-292.
26. SPORN MB. ROBERTS AB: Autocrine growth factors and cancer. Nature 1985; 313: 745-747.
27. SPORN MB, TODARO GJ: Autocrine secretion and malignant transformation of cells. N Engl J Med 1980; 303: 878-880.
28. SUTHERLAND RL, REDDEL RR, GREEN MD: Effects of oestrogens on cell proliferation and cell cycle kinetics. A hypothesis on the cell-cycle effects of antioestrogens. Eur J Cancer Clin Oncol 1983; 19: 307-318.
29. TAUB M, WANG Y, SZCZESNY TM, et al: Epidermal growth factor or transforming growth factor a is required for kidney tubulogenesis in matrigel cultures in serum-free medium. Proc Natl Acad Sci USA 1990; 87: 4002-4006.
30. VALVERIUS EM, BATES SE, STAMPFER MR, et al.: Transforming growth factor α production and EGF receptor expression in normal and oncogene transformed human mammary epithelial cells. Mol Endocrinol 1989; 3: 203-214.
31. WILCOX JN, DERYNCK R: Developmental expression of transforming growth factors alpha and beta in mouse fetus. Mol Cell Biol 1988a; 8: 3415-3422.
32. WILCOX JN, DERYNCK R: Localization of cells synthesizing transforming growth factor-alpha mRNA in the mouse brain. J Neurosci 1988b; 8: 1901-1904.
33. YAMADA K, YOSHITAKE Y, NORIMATSU H, NISHIKAWA K: Roles of various growth factors in growth of human osteosarcoma cells which can grow in protein-free medium. Cell Struct Funct 1992; 17: 9-17.
34. YEH J, REIN M, NOWAK R: Presence of messenger ribonucleic acid for epidermal growth factor (EGF) and EGF receptor demonstrable in monolayer cell-cultures of myometria and leiomyomata. Fertil Steril 1991; 56: 997-1000.