Post-inhalation bronchoconstriction by beclomethasone dipropionate: A comparison of two different CFG propellant formulations in asthmatics

Respirology

Volumn 5, Issue 2, 2000, Pages 125-131

  Ruffin, Richard E ^a,b   Campbell, Donald A ^a,b   Chia, Mon M ^a,b  

^a QUEEN ELIZABETH HOSPITAL   (Australia)

^b UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Asthma; Beclomethasone dipropionate; Bronchoconstriction; Propellant

Indexed keywords

BECLOMETASONE DIPROPIONATE; BUDESONIDE; CHLOROFLUOROCARBON; SURFACTANT; TERBUTALINE;

ADULT; AEROSOL; AGED; ARTICLE; ASTHMA; BRONCHOSPASM; BRONCHUS REACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; MALE; METERED DOSE INHALER; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, INHALATION; ADMINISTRATION, TOPICAL; ADULT; AGED; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BECLOMETHASONE; BRONCHOCONSTRICTION; CHLOROFLUOROCARBONS, METHANE; CROSS-OVER STUDIES; FEMALE; FORCED EXPIRATORY VOLUME; GLUCOCORTICOIDS; HUMANS; MALE; MIDDLE AGED; SINGLE-BLIND METHOD; SURFACE-ACTIVE AGENTS;

EID: 0033945980     PISSN: 13237799     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1843.2000.00238.x     Document Type: Article

References (29)

1. Poh SC, Wang YT. Severe bronchoconstriction after inhalation of beclomethasone and budesonide. Sing. Med. ]. 1986; 27: 247-9.
2. Shim C, Williams MH. Cough and wheezing from beclomethasone aerosol. Chest 1987; 91: 207-9.
3. Eckert B, Armstrong IG, Mitchell CA. Paradoxical bronchoconstriction in patients with stable asthma. Med. ]. Amt. 1993; 159: 566.
4. Eckert B, Mitchell CA. Should bronchodilators be given routinely before aerosol steroids? A review of current approaches. Aust.J. Hasp. Pharm. 1993; 23: 187-9.
5. Shaheen MZ, Ayres JG, Benincasa C. Incidence of acute decreases in peak expiratory flow following the use of metered-dose inhalers in asthmatic patients. Eur. Resp.J. 1994; 7: 2160-4.
6. Cochetto DM, Sykes RS, Spector S. Paradoxical bronchospasm after use of inhalation aerosols: A review of the literature. J. Asthma 1991; 28: 49-53.
7. Wilkinson IR, Roberts JA, Bradding P, Holgate ST, Howarth PH. Paradoxical bronchoconstriction in asthmatic patients after salmeterol by metered dose inhaler. BMJ 1992; 305: 931-2.
8. Finnerty JP, Howarth PH. Paradoxical bronchoconstriction with nebulized albuterol but not with terbutaline. Am. Rev. Resp. Dis. 1993; 148: 512-13.
9. Engel T. Patient-related side effects of CFC propellants. J. Aerosol. Med. 1991; 4: 163-7.
10. Sterling GM, Batten JC. Effect of aerosol propellants and surfactants on airway resistance. Thorax 1969; 24: 22831.
11. Charpin D, Beaupré A, Orehek J. Deep-inspiration induced bronchoconstriction: A mechanism for beclomethasone aerosol intolerance. Eur. J. Respir. Dis. 1983; 64: 494-7.
12. Gayrard P, Orehek J, Grimaud CH, Charpin J. Mechanisms of the bronchoconstrictor effects of deep inspiration in asthmatic patients. Thorax 1979; 34: 234-40.
13. Mann IS, Howarth PH, Holgate ST. Bronchoconstriction induced by ipratropium bromide in asthma: Relation to hypotonicity. BMJ 1984; 289: 469.
14. Moren F, Newhouse MT, Dolovich MB. Aerosols in Medicine: Principles, Diagnosis and Therapy. F.lsevier, Amsterdam, 1985.
15. Fliess J. The Design and Analysis of Clinical Experiments. John Wiley & Sons, New York, 1986.
16. Neter J, Wasserman W, Kutner M. Applied Linear Statistical Models. Richard D. Irwin, Homewood, 1985.
17. Hollander M, Wolfe DA. Nonparametric Statistical Methods. John Wiley & Sons, New York, 1973.
18. Silvasti M, Kohtamaki K, Lehtonen L, Vidgren M, Wenz W. Tolerability of two surfactants in beclomethasone inhalation aerosol formulations in patients with asthma. Drug Invest. 1992; 4: 313-15.
19. McGivern D, MacFarlane J. Severe bronchoconstriction after inhalation of budesonide. BMJ 1989; 288: 268-9.
20. Gayrard P, Orehek J, Grimaud C, Charpin J. Bronchoconstrictor effects of a deep inspiration in patients with asthma. Am. Rev. Resp. Dis. 1975; 111: 433-9.
21. Yarbrough I, Mansfield LE, Ting S. Metered dose inhaler induced bronchospasm in asthmatic patients. Ann. Allergy 1985; 55: 25-7.
22. Fine SR. Possible reaction to soya lecithin in aerosols. J. Allergy Clin. Immunol. 1991; 87: 600.
23. Bryant DH, Pepys J. Bronchial reactions to aerosol inhalant vehicle. BMJ 1976; 1319-20.
24. Godin ), Malo ]L. Acute bronchoconstriction caused by Beclovent and not Vanceril. Clin. Allergy 1979; 9: 5859.
25. Beasley R, Rafferty P, Holgate S. Benzalkonium chloride and bronchoconstriction. Lancet 1986; 2: 1227.
26. Beasley CR, Rafferty P, Holgate ST. Bronchoconstrictor properties of preservatives in ipratropium bromide (Atrovent) nebuliser solution. BM/1987; 294: 1197-8.
27. Ahmad D. Effects of aerosol propellants on airways function in metered dose inhalers. In: SW Epstein (ed.). Astra Pharmaceuticals, Canada, 1984: 22-6.
28. Yarbrough J, Mansfield LE, Ting S. Immediate bronchoconstriction response to metered dose albuterol. (Abstract 5). Ann. Allergy 1983; 50: 363.
29. M011er NE, Hyldgaard-Jensen NC. Side-effects of aerosol therapy with freon dispersal in patients with asthma and cystic fibrosis. Ugeskr. I.g. 1979; 141: 2892-2893.