Fusion of the nucleoporin gene, NUP98, and the putative RNA helicase gene, DDX10, by inversion 11 (p15q22) chromosome translocation in a patient with etoposide-related myelodysplastic syndrome

Internal Medicine

Volumn 39, Issue 5, 2000, Pages 412-415

  Nakao, Katsuyuki ^a,c   Nishino, Maki ^a   Takeuchi, Kyoko ^a   Iwata, Masayasu ^a   Kawano, Akira ^a   Arai, Yasuhito ^b   Ohki, Misao ^b  

^a Okawa General Hospital   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c Department of Internal Medicine   (Japan)

Author keywords

Fusion gene; NUP98 DDX10 fusion; Secondary leukemia; Therapy related myelodysplastic syndrome

Indexed keywords

CD33 ANTIGEN; CD36 ANTIGEN; CISPLATIN; CYTARABINE 5' STEARYLPHOSPHATE; ETOPOSIDE; HLA DR ANTIGEN; LACTATE DEHYDROGENASE; LYSOZYME; MICROSOMAL AMINOPEPTIDASE; NUCLEOPORIN; RNA HELICASE;

ADULT; ARTICLE; BIOPSY; CASE REPORT; CHROMOSOME 11P; CHROMOSOME ANALYSIS; CHROMOSOME INVERSION; CHROMOSOME TRANSLOCATION; COMPUTER ASSISTED TOMOGRAPHY; GENE; GENE FUSION; GERM CELL TUMOR; HUMAN; IMMUNOPHENOTYPING; MALE; MYELODYSPLASTIC SYNDROME; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBOSOME;

EID: 0033945953     PISSN: 09182918     EISSN: None     Source Type: Journal    
DOI: 10.2169/internalmedicine.39.412     Document Type: Article

References (13)

1. Pedersen-Bjergaard J, Rowley JD. The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformaton. Blood 83:2780-2786, 1994.
2. Arai Y, Hosoda F, Kobayashi H, et al. The inv(II)(p15q22) chromosome translocation of de novo and therapy-related myeloid malignancies results in fusion of the nucleoporin gene, NUP98, with the putative RNA helicase gene. DDX10. Blood 89: 3936-3944, 1997.
3. Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol 51: 189-199, 1982.
4. Pedersen-Bjergaard J, Daugaard G, Hansen SW, et al. Increased risk of myelodysplasia and leukaemia after etoposide, cisplatin, and bleomycin for germ-cell tumours. Lancet 338: 359-363, 1991.
5. Whitlock JA, Greer JP, Lukens JN. Epipodophyllotoxin-related leukemia: Identification of a new subset of secondary leukemia. Cancer 68: 600-604, 1991.
6. Maraschin J, Dutrillaux B, Aurias A. Chromosome aberrations induced by etoposide (VP-16) are not random. Int J Cancer 46: 808-812, 1990.
7. Kobayashi H, Arai Y, Hosoda F, et al. Inversion of chromosome 11, inv (11) (p15q22), as a recurring chromosomal aberration associated with de novo and secondary myeloid malignancies: Identification of a P1 clone spanning the 11q22 breakpoint. Genes Chromosom Cancer 19; 150-155, 1997.
8. Yamamoto K, Seto M, Iida S, et al. A reverse transcriptase-polymerase chain reaction detects heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities. Blood 83: 2912-2921, 1994.
9. Savitsky K, Ziv Y, Bar-Shira A, et al. A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23. Genomics 33: 199-206, 1996.
10. Schmid SR, Linder P. D-E-A-D protein family of putative RNA helicases. Mol Microbiol 6: 283-292, 1992.
11. Nakamura T, Largaespada DA, Lee MP, et al. Fusion of the nucleoporin gene NUP98 to HOXA9 by the chromosome translocation t (7;11) (p15;p15) in human myeloid leukaemia. Nature Genet 12: 154-158, 1996.
12. Borrow J, Shearman AM, Stanton Jr VP, et al. The t (7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nature Genet 12: 159-167, 1996.
13. Radu A, Moore MS, Blobel G. The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complex. Cell 81: 215-222, 1995.