Caveolin proteins in signaling, oncogenic transformation and muscular dystrophy

Journal of Cell Science

Volumn 113, Issue 12, 2000, Pages 2103-2109

  Razani, Babak ^a   Schlegel, Amnon ^a   Lisanti, Michael P ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Caveolae; Caveolin; Signal transduction

Indexed keywords

CAVEOLIN;

DOWN REGULATION; GENE DELETION; GENE MUTATION; HOMEOSTASIS; HUMAN; MALIGNANT TRANSFORMATION; MOLECULAR GENETICS; MUSCULAR DYSTROPHY; NOTE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL NOISE RATIO; SIGNAL TRANSDUCTION;

ADULT; AMINO ACID SEQUENCE; ANIMALS; CAVEOLIN 1; CAVEOLINS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUSCULAR DYSTROPHIES; SIGNAL TRANSDUCTION;

EID: 0033945943     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Note

References (14)

1. Achille, A., Biasi, M. O., Zamboni, G., Bogina, G., Magalini, A. R., Pederzoli, P., Perucho, M. and Scarpa, A. (1996). Chromosome 7q allelic losses in pancreatic carcinoma. Cancer Res. 56, 3808-3813.
2. Anderson, R. G. W. (1998). The caveolae membrane system. Annu. Rev. Biochem. 67, 199-225.
3. Bieche, I., Champeme, M. H., Matifas, F., Hacene, K., Callahan, R. and Lidereau, R. (1992). Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer. Lancet 339, 139-143.
4. Carman, C. V., Lisanti, M. P. and Benovic, J. L. (1999). Regulation of G protein-coupled receptor kinases (GRKs) by caveolin. J. Biol. Chem. 274, 8858-8864.
5. Champeme, M. H., Bieche, I., Beuzelin, M. and Lidereau, R. (1995). Loss of heterozygosity on 7q31 occurs early during breast tumorigenesis. Genes Chromosomes Cancer 12, 304-306.
6. Couet, J., Li, S., Okamoto, T., Scherer, P. S. and Lisanti, M. P. (1997a). Molecular and cellular biology of caveolae: Paradoxes and Plasticities. Trends Cardiovasc. Med. 7, 103-110.
7. Couet, J., Li., S., Okamoto, T., Ikezu, T. and Lisanti, M. P. (1997b). Identification of peptide and protein ligands for the caveolin-scaffolding domain. Implications for the interaction of caveolin with caveolae-associated proteins. J. Biol. Chem. 272, 6525-6533.
8. Couet, J., Sargiacomo, M. and Lisanti, M. P. (1997c). Interaction of a receptor tyrosine kinase, EGF-R, with caveolins. Caveolin binding negatively regulates tyrosine and serine/threonine kinase activities. J. Biol. Chem. 272, 30429-30438.
9. Engelman, J. A., Wycoff, C. C., Yasuhara, S., Song, K. S., Okamoto, T. and Lisanti, M. P. (1997). Recombinant expression of caveolin-1 in oncogenically transformed cells abrogates anchorage-independent growth. J. Biol. Chem. 272, 16374-16381.
10. Engelman, J. A., Lee, R. J., Karnezis, A., Bearss, D. J., Webster, M., Siegel, P., Muller, W. J., Windle, J. J., Pestell, R. G. and Lisanti, M. P. (1998a). Reciprocal regulation of Neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo. Implications for human breast cancer. J. Biol. Chem. 273, 20448-20455.
11. Engelman, J. A., Zhang, X. L., Galbiati, F. and Lisanti, M. P. (1998b). Chromosomal localization, genomic organization and developmental expression of the murine caveolin gene family (Cav-1, -2 and -3). Cav-1 and Cav-2 genes map to a known tumor suppressor locus (6-A2/ 7q31). FEBS Lett. 429, 330-336.
12. Engelman, J. A., Zhang, X. L., Galbiati, F., Volonte, D., Sotgia, F., Pestell, R. G., Minetti, C., Scherer, P. E., Okamoto, T. and Lisanti, M. P. (1998c). Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer's disease and muscular dystrophy. Am. J. Hum. Genet. 63, 1578-1587.
13. Engelman, J. A., Zhang, X. L. and Lisanti, M. P. (1998d). Genes encoding human caveolin-1 and -2 are co-localized to the D7S522 locus (7q31. 1), a known fragile site (FRA7G) that is frequently deleted in human cancers. FEBS Lett. 436, 403-410.
14. Engelman, J. A., Zhang, X. L. and Lisanti, M. P. (1999). Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31. 1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines. FEBS Lett. 448, 221-230.