Failure to find mutations in ubiquitin carboxy-terminal hydrolase L1 gene in familial Parkinson's disease

Parkinsonism and Related Disorders

Volumn 6, Issue 4, 2000, Pages 199-200

  Zhang, J ^a   Hattori, N ^a   Giladi, N ^b   Mizuno, Y ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Autosomal dominant Parkinson's disease; Genetics; Parkinson's disease; Ubiquitin carboxy terminal hydrolase L1

Indexed keywords

HYDROLASE; UBIQUITIN;

ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ETHNIC DIFFERENCE; EXON; FAMILIAL DISEASE; FAMILY STUDY; GENE MUTATION; HUMAN; JAPAN; MISSENSE MUTATION; PARKINSON DISEASE; PRIORITY JOURNAL; SEQUENCE ANALYSIS; TURKEY (REPUBLIC);

EID: 0033945827     PISSN: 13538020     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1353-8020(00)00022-5     Document Type: Article

References (6)

1. Leroy E., Boyer R., Auburger G., et al. The ubiquitin pathway in Parkinson's disease. Nature. 395:1998;451-452.
2. Lowe J., McDermott H., Landon M., et al. Ubiquitin carboxyl-terminal hydrolase (PGP9.5) is selectively present in ubiquitinated inclusion bodies characteristic of human neurodegenerative diseases. J Pathol. 161:1990;153-160.
3. Maraganore D.M., Harding A.E., Marsden C.D. A clinical and genetic study of familial Parkinson's disease. Mov Disord. 6:1991;205-211.
4. Sambrook J., Fritsch E.F., Maniatis T. Molecular cloning: a laboratory manual. 2nd ed. 1989;9.16-9.23 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
5. Larsen C.N., Krantz B.A., Wilkinson K.D. Substrate specificity of deubiquitinating enzymes: ubiquitin C-terminal hydrolases. Biochemistry. 37:1998;3358-3368.
6. Lincoln S., Vaughan J., Wood N., et al. Low frequency of pathogenic mutations in the ubiquitin carboxy-terminal hydrolase gene in familial Parkinson's disease. NeuroReport. 10:1999;427-429.