메뉴 건너뛰기




Volumn 108, Issue 5, 2000, Pages 435-439

Assessing potential health risks from microcystin toxins in blue-green algae dietary supplements

Author keywords

Aphanizomenon flos aquae; Blue green algae; Cyanobacteria; Dietary supplements; Microcystins; Microcystis aeruginosa

Indexed keywords

CYANOGINOSIN; CYANOGINOSIN LR; DRINKING WATER; SURFACE WATER; TUMOR PROMOTER;

EID: 0033944639     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.00108435     Document Type: Article
Times cited : (225)

References (51)
  • 1
    • 0028192146 scopus 로고
    • Microcystin class of toxins: Health effects and safety of drinking water supplies
    • Lambert TW, Holmes CFB, Hrudey SE. Microcystin class of toxins: health effects and safety of drinking water supplies. Environ Rev 2:167-186 (1994).
    • (1994) Environ Rev , vol.2 , pp. 167-186
    • Lambert, T.W.1    Holmes, C.F.B.2    Hrudey, S.E.3
  • 2
    • 0003035075 scopus 로고
    • Diseases related to freshwater blue-green algal toxins, and control measures
    • (Falconer IR, ed.) London:Academic Press
    • Carmichael WW, Falconer IR. Diseases related to freshwater blue-green algal toxins, and control measures. In: Algal Toxins in Seafood and Drinking Water (Falconer IR, ed.) London:Academic Press, 1993;187-209.
    • (1993) Algal Toxins in Seafood and Drinking Water , pp. 187-209
    • Carmichael, W.W.1    Falconer, I.R.2
  • 4
    • 0026207193 scopus 로고
    • Cyanobacterial (blue-green algal) toxins and their significance in UK and European waters
    • Lawton LA, Codd GA. Cyanobacterial (blue-green algal) toxins and their significance in UK and European waters. J Chartered Inst Water Environ Manage 5:460-465 (1991).
    • (1991) J Chartered Inst Water Environ Manage , vol.5 , pp. 460-465
    • Lawton, L.A.1    Codd, G.A.2
  • 5
    • 0033034114 scopus 로고    scopus 로고
    • An overview of problems caused by toxic blue-green algae (cyanobacteria) in drinking and recreational water
    • Falconer IR. An overview of problems caused by toxic blue-green algae (cyanobacteria) in drinking and recreational water. Environ Toxicol 14:5-12 (1999).
    • (1999) Environ Toxicol , vol.14 , pp. 5-12
    • Falconer, I.R.1
  • 8
    • 0031886197 scopus 로고    scopus 로고
    • Microcystin toxicosis in cattle due to overgrowth of blue-green algae
    • Frazier K, Colvin B, Styer E, Hullinger G. Microcystin toxicosis in cattle due to overgrowth of blue-green algae. Vet Human Toxicol 40:23-24 (1998).
    • (1998) Vet Human Toxicol , vol.40 , pp. 23-24
    • Frazier, K.1    Colvin, B.2    Styer, E.3    Hullinger, G.4
  • 9
    • 0021344304 scopus 로고
    • Clinical and pathological changes in sheep experimentally poisoned by the blue-green alga Microcystis aeruginosa
    • Jackson ARB, McInnes A, Falconer IR, Runnegar MTC. Clinical and pathological changes in sheep experimentally poisoned by the blue-green alga Microcystis aeruginosa. Vet Pathol 21:102-113 (1984).
    • (1984) Vet Pathol , vol.21 , pp. 102-113
    • Jackson, A.R.B.1    McInnes, A.2    Falconer, I.R.3    Runnegar, M.T.C.4
  • 10
    • 0026623311 scopus 로고
    • Cyanobacteria and human health
    • Hunter PR. Cyanobacteria and human health. J Med Microbiol 36:301-302 (1992).
    • (1992) J Med Microbiol , vol.36 , pp. 301-302
    • Hunter, P.R.1
  • 11
    • 0343983165 scopus 로고
    • Blue-green algae: An overlooked health threat
    • Carmichael WW. Blue-green algae: an overlooked health threat. Health Environ Dig 5:1-4 (1991).
    • (1991) Health Environ Dig , vol.5 , pp. 1-4
    • Carmichael, W.W.1
  • 12
    • 0020501395 scopus 로고
    • Evidence of liver damage by toxin from a bloom of the blue-green alga, Microcystis aeruginosa
    • Falconer IR, Beresford AM, Runnegar MTC. Evidence of liver damage by toxin from a bloom of the blue-green alga, Microcystis aeruginosa. Med J Aust 1:511-514 (1983).
    • (1983) Med J Aust , vol.1 , pp. 511-514
    • Falconer, I.R.1    Beresford, A.M.2    Runnegar, M.T.C.3
  • 14
    • 0028127691 scopus 로고
    • The toxins of cyanobacteria
    • Carmichael WW. The toxins of cyanobacteria. Sci Am 270:78-86 (1994).
    • (1994) Sci Am , vol.270 , pp. 78-86
    • Carmichael, W.W.1
  • 16
    • 0024399654 scopus 로고
    • Production and characterization of antibodies against microcystins
    • Chu FS, Huang X, Wei RD, Carmichael WW. Production and characterization of antibodies against microcystins. Appl Environ Microbiol 55:1928-1933 (1989).
    • (1989) Appl Environ Microbiol , vol.55 , pp. 1928-1933
    • Chu, F.S.1    Huang, X.2    Wei, R.D.3    Carmichael, W.W.4
  • 17
    • 0025423140 scopus 로고
    • Enzyme-linked immunosorbant assay for microcystins in blue-green algal blooms
    • Chu FS, Huang X, Wei RD. Enzyme-linked immunosorbant assay for microcystins in blue-green algal blooms. J Assoc Off Anal Chem 73:451-456 (1990).
    • (1990) J Assoc Off Anal Chem , vol.73 , pp. 451-456
    • Chu, F.S.1    Huang, X.2    Wei, R.D.3
  • 18
    • 0003080927 scopus 로고    scopus 로고
    • Toxic Microcystis in the environment
    • (Watanabe MF, Harada KI, Carmichael WW, Fujiki H, eds). New York:CRC Press
    • Carmichael WW. Toxic Microcystis in the environment. In: Toxic Microcystis (Watanabe MF, Harada KI, Carmichael WW, Fujiki H, eds). New York:CRC Press, 1996;1-11.
    • (1996) Toxic Microcystis , pp. 1-11
    • Carmichael, W.W.1
  • 19
    • 0029803289 scopus 로고    scopus 로고
    • Evolution of science-based uncertainty factors in noncancer risk assessment
    • Dourson ML, Felter SP, Robinson D. Evolution of science-based uncertainty factors in noncancer risk assessment. Regul Toxicol Pharmacol 24:108-120 (1996).
    • (1996) Regul Toxicol Pharmacol , vol.24 , pp. 108-120
    • Dourson, M.L.1    Felter, S.P.2    Robinson, D.3
  • 20
    • 0032974377 scopus 로고    scopus 로고
    • The toxicity of cyanobacterial toxins in the mouse. I: Microcystin-LR
    • Fawell JK, Mitchell RE, Everett DJ, Hill RE. The toxicity of cyanobacterial toxins in the mouse. I: Microcystin-LR. Human Exp Toxicol 18:162-167 (1999).
    • (1999) Human Exp Toxicol , vol.18 , pp. 162-167
    • Fawell, J.K.1    Mitchell, R.E.2    Everett, D.J.3    Hill, R.E.4
  • 21
    • 1942477238 scopus 로고    scopus 로고
    • Document for Public Comment. Ottawa, Ontario, Canada:Federal-Provincial Subcommittee on Drinking Water
    • Federal-Provincial Subcommittee on Drinking Water. Cyanobacterial Toxins - Microcystins in Drinking Water. Document for Public Comment. Ottawa, Ontario, Canada:Federal-Provincial Subcommittee on Drinking Water, 1998.
    • (1998) Cyanobacterial Toxins - Microcystins in Drinking Water
  • 22
    • 0038672387 scopus 로고    scopus 로고
    • Addendum to Health Criteria and Other Supporting Information. Geneva:World Health Organization
    • WHO. Guidelines for Drinking Water Quality, 2nd ed. Addendum to Vol 2, Health Criteria and Other Supporting Information. Geneva:World Health Organization, 1998.
    • (1998) Guidelines for Drinking Water Quality, 2nd Ed. , vol.2
  • 23
    • 85037960906 scopus 로고    scopus 로고
    • Unpublished observations
    • Park J, Chu FS. Unpublished observations.
    • Park, J.1    Chu, F.S.2
  • 24
    • 85037959394 scopus 로고    scopus 로고
    • Personal communication
    • Carmichael WW. Personal communication.
    • Carmichael, W.W.1
  • 25
    • 0000900824 scopus 로고    scopus 로고
    • Chemistry and detection of microcystins
    • (Watanabe MF, Harada KI, Carmichael WW, Fujiki H, eds). New York:CRC Press
    • Harada K. Chemistry and detection of microcystins. In: Toxic Microcystis (Watanabe MF, Harada KI, Carmichael WW, Fujiki H, eds). New York:CRC Press, 1996;103-148.
    • (1996) Toxic Microcystis , pp. 103-148
    • Harada, K.1
  • 26
    • 0027386790 scopus 로고
    • Characterization of heptapeptide toxins extracted from Microcystis aeruginosa (Egyptian isolate). Comparison with some synthesized analogs
    • Abdel-Rahman S, el-Ayouty YM, Kamael HA. Characterization of heptapeptide toxins extracted from Microcystis aeruginosa (Egyptian isolate). Comparison with some synthesized analogs. Int J Pept Protein Res 41:1-7 (1993).
    • (1993) Int J Pept Protein Res , vol.41 , pp. 1-7
    • Abdel-Rahman, S.1    El-Ayouty, Y.M.2    Kamael, H.A.3
  • 27
    • 0028219150 scopus 로고
    • Toxicity of the blue-green alga (cyanobacterium) Microcystis aeruginosa in drinking water to growing pigs, as an animal model for human injury and risk assessment
    • Falconer IR, Burch MD, Steffensen DA, Choice M, Coverdale OR. Toxicity of the blue-green alga (cyanobacterium) Microcystis aeruginosa in drinking water to growing pigs, as an animal model for human injury and risk assessment. Environ Toxicol Water Qual 9:131-139 (1994).
    • (1994) Environ Toxicol Water Qual , vol.9 , pp. 131-139
    • Falconer, I.R.1    Burch, M.D.2    Steffensen, D.A.3    Choice, M.4    Coverdale, O.R.5
  • 28
    • 0000504046 scopus 로고    scopus 로고
    • Toxicology of microcystins
    • (Watanabe MF, Harada KI, Carmichael WW, Fujiki H, eds). New York:CRC Press
    • Kaya K. Toxicology of microcystins. In: Toxic Microcystis (Watanabe MF, Harada KI, Carmichael WW, Fujiki H, eds). New York:CRC Press, 1996;175-202.
    • (1996) Toxic Microcystis , pp. 175-202
    • Kaya, K.1
  • 29
    • 0001651199 scopus 로고
    • Mechanism of toxicity of cyclic peptide toxins from blue-green algae
    • (Falconer IR, ed). London:Academic Press
    • Falconer IR. Mechanism of toxicity of cyclic peptide toxins from blue-green algae. In: Algal Toxins in Seafood and Drinking Water (Falconer IR, ed). London:Academic Press, 1993;177-186.
    • (1993) Algal Toxins in Seafood and Drinking Water , pp. 177-186
    • Falconer, I.R.1
  • 30
    • 0023762338 scopus 로고
    • Oral toxicity of a bloom of the cyanobacterium Microcystis aeruginosa administered to mice over periods up to 1 year
    • Falconer IR, Smith JV, Jackson ARB, Jones A, Runnegar MTC. Oral toxicity of a bloom of the cyanobacterium Microcystis aeruginosa administered to mice over periods up to 1 year. J Toxicol Environ Health 24:291-305 (1988).
    • (1988) J Toxicol Environ Health , vol.24 , pp. 291-305
    • Falconer, I.R.1    Smith, J.V.2    Jackson, A.R.B.3    Jones, A.4    Runnegar, M.T.C.5
  • 31
    • 0031819725 scopus 로고    scopus 로고
    • Prolonged sublethal exposure to the protein phosphatase inhibitor microcystin-LR results in multiple dose-dependent hepatotoxic effects
    • Solter PF, Wollenberg GK, Huang X, Chu FS, Runnegar MT. Prolonged sublethal exposure to the protein phosphatase inhibitor microcystin-LR results in multiple dose-dependent hepatotoxic effects. Toxicol Sci 44:87-96 (1998).
    • (1998) Toxicol Sci , vol.44 , pp. 87-96
    • Solter, P.F.1    Wollenberg, G.K.2    Huang, X.3    Chu, F.S.4    Runnegar, M.T.5
  • 32
    • 0031976870 scopus 로고    scopus 로고
    • Immunohistochemical localization of microcystin-LR in the liver of mice: A study on the pathogenesis of microcystin-LR-induced hepatotoxicity
    • Yoshida T, Makita Y, Tsutsumi T, Nagata S, Tashiro F, Yoshida F, Sekijima M, Tamura S, Harada T, Maita K, et al. Immunohistochemical localization of microcystin-LR in the liver of mice: a study on the pathogenesis of microcystin-LR-induced hepatotoxicity. Toxicol Pathol 26:411-418 (1998).
    • (1998) Toxicol Pathol , vol.26 , pp. 411-418
    • Yoshida, T.1    Makita, Y.2    Tsutsumi, T.3    Nagata, S.4    Tashiro, F.5    Yoshida, F.6    Sekijima, M.7    Tamura, S.8    Harada, T.9    Maita, K.10
  • 34
    • 0000265235 scopus 로고
    • Kinetics of distribution of microcystin-LR in serum and liver cytosol of mice: An immunochemical analysis
    • Lin J, Chu FS. Kinetics of distribution of microcystin-LR in serum and liver cytosol of mice: an immunochemical analysis. J Agric Food Chem 42:1035-1040 (1994).
    • (1994) J Agric Food Chem , vol.42 , pp. 1035-1040
    • Lin, J.1    Chu, F.S.2
  • 37
    • 0025730098 scopus 로고
    • Tumor promotion and liver injury caused by oral consumption of cyanobacteria
    • Falconer IR. Tumor promotion and liver injury caused by oral consumption of cyanobacteria. Environ Toxicol Water Qual 6:177-184 (1991) .
    • (1991) Environ Toxicol Water Qual , vol.6 , pp. 177-184
    • Falconer, I.R.1
  • 39
    • 0000177737 scopus 로고    scopus 로고
    • Carcinogenesis of microcystins
    • (Watanabe MF, Harada KI, Carmichael WW, Fujiki H, eds). New York:CRC Press
    • Fujiki H, Sueoka E, Suganuma M. Carcinogenesis of microcystins. In: Toxic Microcystis (Watanabe MF, Harada KI, Carmichael WW, Fujiki H, eds). New York:CRC Press, 1996;202-232.
    • (1996) Toxic Microcystis , pp. 202-232
    • Fujiki, H.1    Sueoka, E.2    Suganuma, M.3
  • 40
    • 0028950664 scopus 로고
    • Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: Method of analysis of interactions of tight-binding ligands with target protein
    • Takai A, Sasaki K, Nagai H, Mieskes G, Isobe M, Isono K, Yasumoto T. Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein. Biochem J 306:657-665 (1995).
    • (1995) Biochem J , vol.306 , pp. 657-665
    • Takai, A.1    Sasaki, K.2    Nagai, H.3    Mieskes, G.4    Isobe, M.5    Isono, K.6    Yasumoto, T.7
  • 41
    • 0030006616 scopus 로고    scopus 로고
    • Detection of microcystins, a blue-green algal hepatotaxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay
    • Ueno Y, Nagata S, Tsutsumi T, Hasegawa A, Watanabe MF, Park H, Chen GC, Chen G, Yu S. Detection of microcystins, a blue-green algal hepatotaxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay. Carcinogenesis 17:1317-1321 (1996).
    • (1996) Carcinogenesis , vol.17 , pp. 1317-1321
    • Ueno, Y.1    Nagata, S.2    Tsutsumi, T.3    Hasegawa, A.4    Watanabe, M.F.5    Park, H.6    Chen, G.C.7    Chen, G.8    Yu, S.9
  • 42
    • 0028818446 scopus 로고
    • Primary prevention of hepatocellular carcinoma
    • Yu S. Primary prevention of hepatocellular carcinoma. J Gastroenterol Hepatol 10:674-682 (1995).
    • (1995) J Gastroenterol Hepatol , vol.10 , pp. 674-682
    • Yu, S.1
  • 44
    • 0030623448 scopus 로고    scopus 로고
    • Cyanobacterial toxins: Occurrence, modes of action, health effects and exposure routes
    • Applied Toxicology: Approaches Through Basic Science. Proceedings of the 1996 EUROTOX Meeting, 22-25 September 1996, Alicante, Spain. (Seiler JP, Vilanova E, eds). Berlin:Springer-Verlag
    • Codd GA, Ward CJ, Bell SG. Cyanobacterial toxins: occurrence, modes of action, health effects and exposure routes. In: Applied Toxicology: Approaches Through Basic Science. Proceedings of the 1996 EUROTOX Meeting, 22-25 September 1996, Alicante, Spain. Archives of Toxicology Supplement 19 (Seiler JP, Vilanova E, eds). Berlin:Springer-Verlag, 1997;399-410.
    • (1997) Archives of Toxicology Supplement , vol.19 , pp. 399-410
    • Codd, G.A.1    Ward, C.J.2    Bell, S.G.3
  • 45
    • 85037960990 scopus 로고    scopus 로고
    • unpublished observations
    • Huang X, Chu FS. unpublished observations.
    • Huang, X.1    Chu, F.S.2
  • 46
    • 85037960505 scopus 로고    scopus 로고
    • Dietary Supplement Health and Education Act. Public Law 103-417, Section 13, 1994
    • Dietary Supplement Health and Education Act. Public Law 103-417, Section 13, 1994.
  • 48
    • 0032541599 scopus 로고    scopus 로고
    • Alternative medicine - The risks of untested and unregulated remedies
    • Angell M, Kassirer JP. Alternative medicine - the risks of untested and unregulated remedies. N Engl J Med 339:839-841 (1998).
    • (1998) N Engl J Med , vol.339 , pp. 839-841
    • Angell, M.1    Kassirer, J.P.2
  • 49
    • 0030228814 scopus 로고    scopus 로고
    • Herbal medicine at a crossroads
    • Taylor D. Herbal medicine at a crossroads. Environ Health Perspect 104:924-928 (1996).
    • (1996) Environ Health Perspect , vol.104 , pp. 924-928
    • Taylor, D.1
  • 50
    • 0032159864 scopus 로고    scopus 로고
    • An FDA guide to dietary supplements
    • Kurtzweil P. An FDA guide to dietary supplements. FDA Consumer Sept-Oct:28-35 (1998).
    • (1998) FDA Consumer , vol.SEPT-OCT , pp. 28-35
    • Kurtzweil, P.1
  • 51
    • 0003771587 scopus 로고    scopus 로고
    • cited 7 June
    • U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Special Nutritionals. The Special Nutritionals Adverse Event Monitoring System Available: http://vm.cfsan.fda.gov/-dms/aems.html [cited 7 June 1999].
    • (1999) The Special Nutritionals Adverse Event Monitoring System


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.