A paraneoplastic mixed bullous skin disease: Breakdown in tolerance to multiple epidermal antigens

British Journal of Dermatology

Volumn 143, Issue 1, 2000, Pages 149-153

  Musette, P ^a   Joly, P ^a   Gilbert, D ^a   Marinho, E ^a   Crickx, B ^a   Tron, F ^b   Belaich, S ^b   Descamps, V ^b  

^a BICHAT HOSPITAL   (France)

^b HÔPITAL CHARLES NICOLLE   (France)

Author keywords

Bullous skin disease; Lymphoma; Paraneoplastic skin disease; Tolerance

Indexed keywords

DESMOGLEIN; DESMOPLAKIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN G4; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN M ANTIBODY; MONOCLONAL ANTIBODY;

ADULT; ARTICLE; B CELL LYMPHOMA; BULLOUS SKIN DISEASE; CASE REPORT; CLINICAL FEATURE; DISEASE ASSOCIATION; EPIDERMIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOELECTRON MICROSCOPY; MALE; PARANEOPLASTIC SYNDROME; PARAPROTEINEMIA; PRIORITY JOURNAL;

AUTOANTIBODIES; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HUMANS; IMMUNOBLOTTING; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LYMPHOMA, B-CELL; MALE; MIDDLE AGED; PARAPROTEINEMIAS; PRECANCEROUS CONDITIONS; SKIN DISEASES, VESICULOBULLOUS;

EID: 0033943706     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.2000.03605.x     Document Type: Article

References (23)

1. Anhalt GJ, Kim S, Stanley JR et nl Paraneoplastic pemphigus: an autoimmune mucocutaneous disease associated with neoplasia. N Engl J Med 1990: 323: 1729-35.
2. Bystryn JC, Hodak E, Shun-Quiang G et al. A paraneoplastic mixed bullous skin disease associated with anti-skin antibodies and a B-cell lymphoma. Arch Dermatol 1993; 129: 870-5.
3. Kim SC, Kwon YD, Lee IJ et al. cDNA cloning of the 210-kDa paraneoplastic pemphigus antigen reveals that envoplakin is a component of the antigen complex. J Invest Dermatol 1997; 109: 365-9.
4. Mahoney MG, Aho S, Uitto J, Stanley JR. The members of the plakin family of proteins recogni2ed by paraneoplastic pemphigus antibodies include periplakin. J Invest Dermatol 1998; 111:308-13.
5. Gammon WR, Briggaman RA, Inman AO et al. Differentiating anti-lamina lucida and anti-sublamina densa anti-BMZ antibodies %by indirect immunofluorescence on 1.0 M sodium chloride-separated skin. J Invest Dermatol 1984; 82: 139-44.
6. Joly P, Thomine E, Gilbert D et al. Overlapping distribution of autoantibody specificities in paraneoplastic pemphigus and pemphigus vulgaris. J Invest Dermatol 1994: 103: 65-72.
7. Joly P, Gilbert D, Thomine E et al. Identification of a new antibody population directed against a desmosomal plaque antigen in pemphigus vulgaris and pemphigus foliaceus. J Invest Dermatol 1997; 108:469-75.
8. Brouet JC, Clauvel JP, Danon F et ni Biologic and clinical significance of cryoglobulins: a report of 86 cases. Am J Med 1974; 57: 775-88.
9. Liu AY, Valenzuela R, Helm TH et al. Indirect immunofluorescence on rat bladder transitional epithelium: a test with high specificity for paraneoplastic pemphigus. J Am Acad Dermatol 1993; 28: 696-9.
10. Stevens SR. Griffiths CE, Anhalt GJ, Cooper KD. Paraneoplastic pemphigus presenting as lichen planus pemphigoides-Iike eruption. Arch Dermatol 1993; 129: 866-9.
11. Horn TD, Anhalt GJ. Histologie features of paraneoplastic pemphigus. Arch Dermatol 1992; 128: 1091-5.
12. Ishiko A, Shimizu H, Kikuchi A et al. Human autoantibodies against the 230-kD bullous pemphigoid antigen (BPAG1) bind only the intracellular domain of the hemidesmosome, whereas those against the 180-kD bullous pemphigoid antigen (BPAG2) bind along the plasma membrane of the hemidesmosome in normal human and swine skin. J Clin Invest 1993:91: 1608-15.
13. Joly P, Gilbert D, Thomine E et al. Relationship between the in vivo localization and the immunoblotting pattern of anti-basement membrane zone antibodies in patients with bullous pemphigoid. Arch Dermatol 1997: 133: 719-24.
14. Hashimoto T, Amagai M, Watabe K et al. Characterization of paraneoplastic pemphigus autoantigens by immunoblot analysis. J Invest Dermatol 1995; 104: 829-34.
15. Amagai M, Nishikawa T, Nousari HC et ni Antibodies against desmoglein 3 (pemphigus vulgaris antigen) are present in sera from patients with paraneoplastic pemphigus and cause acantholysis in vira in neonatal mice. J Clin Invest 1998; 102: 775-82.
16. Oursler JR, Labib RS, Ariss-Abdo L et al. Human autoantibodies against desmoplakins in paraneoplastic pemphigus. J Clin Invest 1992; 89: 1775-82.
17. Ghohestani R, Joly P, Gilbert D et al. Autoantibody formation against a 190-kDa antigen of the desmosomal plaque in pemphigus foliaceus. Br J Dermatol 1997; 137: 774-9.
18. Joly P, Mokhtar I, Gilbert D et al. Immunoblot and immunomicroscopy analyses of endemic Tunisian pemphigus. Br J Dermatol 1999; 140: 44-9.
19. Foedinger D, Elbe-Bürger A, Sterniczky B et al. Erythema multiforme associated human autoantibodies against desmoplakin I and II biochemical characterization and passive transfer studies into newborn mice. J Invest Dermatol 1998; 111: 503-10.
20. Ghohestani R, Claudy A. Paraneoplastic pemphigus: are autoantibodies pathogenic or an epiphenomenon? Eur J Dermatol 1995; 5: 423-4.
21. Anhalt GJ, Labib RS, Voorhees JJ et al. Induction of pemphigus in neonatal mice by passive transfer of IgG from patients with the disease. N Engl J Med 1982; 306: 1189-96.
22. Liu Z, Diaz LA, Troy JL et al. A passive transfer model of the organspecific autoimmune disease, bullous pemphigoid. using antibodies generated against the hemidesmosomal antigen, BPAg 180. J Clin Invest 1993: 92: 2480-8.
23. Whittaker SJ. Bhogal BS, Black MM. Acquired immunobullous disease: a cutaneous manifestation of IgM macroglobulinaemia. Br] Dermatol 1996; 135: 283-6.