Comparative investigations to determine the biological significance of Ki-67-Antigen and PCNA in primary ovarian carcinomas;Vergleichende untersuchungen zur biologischen bedeutung der proliferationsmarker Ki-67-Antigen und PCNA in primaren ovarialkarzinomen

Zentralblatt fur Gynakologie

Volumn 122, Issue 7, 2000, Pages 361-367

  Reitmaier, M ^c   Rudlowski, C ^c   Biesterfeld, S ^c   Rath, W ^c   Schroder W ^a,b  

^a Frauenklinik   (Germany)

^b Frauenklinik I   (Germany)

^c NONE

Author keywords

Ki 67 Antigen; Ovarian carcinoma; PCNA

Indexed keywords

CYCLINE; KI 67 ANTIGEN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY KI 67;

ANTIGEN EXPRESSION; ARTICLE; CANCER GRADING; CANCER STAGING; CANCER SURVIVAL; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; OVARY CARCINOMA; PROGNOSIS;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA; CELL DIVISION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; MIDDLE AGED; OVARIAN NEOPLASMS; PROGNOSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; SURVIVAL ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 0033943585     PISSN: 00444197     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Alaiya A, Frantzen B, Fujioka K, Moberger B, Schevins K, Silversvärd C, Linder S, Auer G. Phenotypic analysis of ovarian carcinoma: Polypeptide expression in benign, borderline and malignant tumors. Int J Cancer 1997; 73: 678-683
2. Biesterfeld S, Klüppel D, Koch R, Schneider S, Steinhagen G, Mihalcea AM, Schröder W. Rapid and prognostic valid quantification of immuohistochemical reactions by immunohistometry of the most positive tumor focus. A prospective follow-up study on breast cancer using antibodies against MIB-1, PCNA, ER, and PR. J Pathol 1998; 185: 25-31
3. Bravo R, Celis JE. A search for differential polypeptide synthesis throughout the cell cycle of He La cells. J Cell Biol 1980; 84: 795-802
4. Bravo R, MacDonald-Bravo H. Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle. Association with DNA replication sites. J Cell Biol 1987; 105: 1549-1554
5. Bravo R, Frank R, Blundall PA, MacDonald-Bravo H. Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature 1987; 326: 515-517
6. Bruno S, Darzynkiewicz Z. Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells. Cell Prolif 1987; 25: 31-40
7. Yu Carmen C-W, Filipe Isabel. Update on proliferation-associated antibodies applicable to formalin fixed tissue and their clinical applications. Histochemical Journal 1993; 25: 843-853
8. Cattoretti G, Becker M, Key G, Duchrow M, Schlüter C, Gallet J, Gerdes J. Monoclonal antibodies against the Ki-67 antigen (mib 1 and mib 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections. J Pathol 1992; 168: 357-363
9. Celis JE, Madson P. Increased nuclear cyclin/PCNA antigen staining of non S-phase transformed human amnion cells engaged in nucleotid excision DNA-repair. FEBS Lett 1986; 209: 277-283
10. Darai E, Walker-Combrouze F, Dauge-Geoffroy MC, Vincent Y, Feldmann G, Madelenat P, Scoazec LY. Ki-67 expression in 35 borderline ovarian tumors: relations with clinicopathologic parameters and ploidy. Eur J Obstet Gynecol Reprod Biol 1998; 76: 175-180
11. Delahunt B, Bethwaite PB, Nacey JN, Ribas JL. Proliferation cell nuclear antigen (PCNA) expression as a prognostic indicator for renal cell carcinoma: comparision with tumor grade, mitotic index, and silver staining nucleolar oraanizer region numbers. J Pathol 1993; 170: 471-477
12. De Melo N, Matutes E, Cordone I, Morilla R, Catovsky D. Expression of Ki-67 nuclear antigen in B and T cell lymphoproliferative disorders. J Clin Pathol 1992; 45: 660-663
13. Figo Annual Report. On the Results of Treatment in Gynecological Cancer. J Epidem Biostat 1998; 3: 75-102
14. Garzetti G, Ciavattini A, Gotery G, De Nictolis M, Stramazotti D, Guendalina L, Graziella B. Ki-67 Antigen Immunstaining (MIB 1 Monoclonal Antibody) in Serous Ovarian Tumors: Index of Proliferativ Activity with Prognostic Significance. Gynecol Oncol 1995; 56: 169-174
15. Geisler JP, Geisler HE, Wiemann M, Zhou, Miller GA, Crabtree W. MIB-1: a predictor of survival in patients with ovarian carcinoma. Int J Gynecol Cancer 1998; 8: 392-396
16. Gerdes J, Schwab U, Lemke H, Stein H. Production of a monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 1983; 31: 13-20
17. Gerdes J, Becker M, Key G, Cattoretti G. Immunohistological detection of tumor growth fraction (Ki-67 antigen) in formalin-fixed and routinely processed tissues. J Pathol 1992; 168: 85-86
18. Ghazizadeh M, Sasaki Y, Araki T, Konishi H, Aihara K. Prognostic value of proliferative activity of ovarian carcinoma as revealed by PCNA and AgNOR analysis. AJCP 1997; 107: 451-458
19. Hartmann LC, Sebo T, Kamel N, Podratz K, Cha S, Wieand H, Keeney G, Roche P. Proliferation cell nuclear antigen in epithelial ovarian cancer: Relation to results at second-look laparotomy and survival. Gynecol Oncol 1992; 47: 191-195
20. Iatropoulos M, Williams G. Proliferation markers. Exp Toxic Pathol 1996; 48: 175-181
21. Isola J, Kallioniemi OP, Korte JM, Wahistrom T, Aine R, Helle M, Helin H. Steroid receptor and Ki-67 reactivity in ovarian cancer and in normal ovary: Correlation with DNA flow cytometry, biochemical receptor assay, and patient survival. J Pathol 1990; 162: 295-301
22. Kawai T, Suzuki M, Kono S. Proliferating cell nuclear antigen and Ki-67 in lung carcinoma. Correlation with flow cytometryc analysis. Cancer 1994; 74: 2468-2475
23. Leonardi E, Girlando S, Serio G, Mauri FA, Perrone G, Scampini S, Palma D, Barbareschi M. PCNA and Ki-67 expression in breast carcinoma: correlation with clinical and biological variables. J Clin Pathol 1992; 45: 416-419
24. Maeda K, Chung YS, Onoda N. Proliferating cell nuclear antigen labelling index of preoperative biopsy specimens in gastric carcinoma with special reference to prognosis. Cancer 1994; 73: 528-533
25. Miyachi K, Fritzler M, Tan E. Autoantibody to a nuclear antigen in proliferating cells. J Immunol 1978; 121: 2228-2234
26. Nakopoulou L, Janinis J, Pnangos G, Comin G, Davaris P. The immunhistochemical expression of proliferating cell nuclear antigen (PCNA/cyclin) in malignant and benign epithelial ovarian neoplasms and correlation with prognosis. Eur J Cancer 1993; 29: 159-161
27. Nguyen HN, Averette HE, Hoskins W, Sevin BU, Pentalver M, Steren A. National survey of ovarian carcinoma. Critical assessment of current international federation of gynecology and obstetrics staging system. Cancer 1993; 72: 3007-3011
28. Ogata K, Kurki P, Celis JE, Nakamura RM, Tan EM. Monoclonal antibodies to a nuclear protein (PCNA/cyclin) associated with DNA replication. Exp Cell Res 1987; 168: 475-486
29. Rogers S, Wells R, Rechsteiner M. Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis. Science 1986; 234: 364-367
30. Schönborn I, Minguillon C, Reles A, Bartel U, Lichtenegger W. Die Bedeutung der PCNA-Proliferatonsfraktion für die Prognose des Ovarialkarzinoms. Geburtshilfe Frauenheilkd 1996; 56: 357-364
31. Scott RJ, Hall PA, Haldane JS, Van Noorden S, Price Y, Lane DP, Wright NA. A comparision of immunhistochemical markers of cell proliferation with experimentally determined growth fraction. J Pathol 1991; 165: 172-178
32. Shivji KK, Keny MK, Wood RD. Proliferating cell nuclear antigen is required for DNA excision repair. Cell 1992; 69: 367-374
33. Thomas H, Nasim MM, Sarraf CE, Alison MR, Love S, Lambert HE, Price P. Proliferating cell nuclear antigen (PCNA) immunostaining a prognostic factor in ovarian cancer? Br J Cancer 1995; 71: 357-362
34. Toschi L, Bravo R. Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis. J Cell Biol 1988; 107: 1623-1628
35. Van Dierendonck J, Keijzer R, Van de Velde C, Cornelisse C. Nuclear distribution of the Ki-67 antigen during the cell cycle: comparison with growth fraction in human breast cancer cells. Cancer Res 1989; 49: 2999-3006
36. Waseem NH, Lane DP. Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and detection of nucleolar form. J Cell Sci 1990; 96: 121-129