Recombinant factor VIII SQ - Stability of VII: C in homogenates from porcine, monkey and human subcutaneous tissue

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 7, 2000, Pages 797-805

  Fatouros, Angelica ^a   Liden, Ylva ^a   Sjöström, Brita ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; BESTATIN; LEUPEPTIN; LIPOSOME; PEPSTATIN; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLSERINE; PHOSPHORAMIDON; RECOMBINANT BLOOD CLOTTING FACTOR 8; VON WILLEBRAND FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG ADSORPTION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG STABILITY; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MONKEY; NONHUMAN; PROTEIN DEGRADATION; SUBCUTANEOUS TISSUE; SWINE;

EID: 0033942496     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001774651     Document Type: Article

References (24)

1. Andersson, L.-O., Brown, J, E. (1981) Interaction of factor VIII-von Willebrand factor with phospholipid vesicles. Biochem. J. 200: 161-167
2. Andersson, L. O., Forsman, N., Huang, K., Larsen, K., Lundin, A., Pavlu, B., Sandberg, H., Sewerin, K., Smart, J. (1986) Isolation and characterization of human factor VIII: molecular forms in commercial factor VIII concentrate, cryoprecipitate, and plasma. Proc. Natl Acad. Sci. USA 83: 2979-2983
3. Fay, P. J. (1993) Factor VIII structure and function. Thromb. Haemost. 70: 63-37
4. Fowler, W. E., Fay, P. J., Arvan, D. S., Marder, V. J. (1990) Electron microscopy of human factor V and factor VIII: correlation of morphology with domain structure and localization of factor V activation fragments. Proc. Natl Acad. Sci. USA 87: 7648-7652
5. Gilbert, G. E., Furie, B. C., Furie, B. (1990) Binding of human factor VIII to phospholipid vesicles. J. Biol. Chem. 265: 815-822
6. Hamer, R. J. (1986) FVIII. Isolation, characterization and interaction with von Willebrand factor. PhD Thesis. University of Utrecht
7. Hawley, A. E., Davis, S. S., Illum, L. (1995) Targeting of colloids to lymph nodes: influence of lymphatic physiology and colloidal characteristics. Adv. Drug Del. Rev. 17: 129-148
8. Hemker, H. C., Kahn, M. J. P. (1967) Reaction sequence of blood coagulation. Nature 215: 1201-1202
9. Hemker, H. C., Kahn, M. J. P., Devilee, P. P. (1970) The adsorption of coagulation factors onto phopholipids. Its role in the reaction mechanism of blood coagulation. Thromb. Diath. Haemorrh. 24: 214-223
10. Hoyer, L. W. (1994) Hemophilia A. N. Engl. J. Med. 330: 38-47
11. Jorgensen, J. O., Flyvbjerg, A., Lauritzen, T., Orskov, H., Christiansen, J. S. (1988) Subcutaneous degradation of biosynthetic human growth hormone in growth hormone deficient patients. Acta Endocrinol. Copenh. 118: 154-158
12. Koedam, J. A., Meijers, J. C. M., Sixma, J. J., Bouma, B. N. (1987) Von Willebrand factor protects factor VIII from inactivation by activated protein C and protein S. Thromb. Haemost. 58: 223a
13. Laursen, T., Moller, J., Jorgensen, J. O. L., Orskov, H., Christiansen, J. S. (1996) Bioavailability and bioactivity of intravenous vs subcutaneous infusion of growth hormone in GH-deficient patients. Clin. Endocrinol. 45: 333-339
14. Lind, P., Larsson, K., Spira, J., Sydow Backman, M., Almstedt, A., Gray, E., Sandberg, H. (1995) Novel forms of B-domain-deleted recombinant factor VIII molecules. Construction and biochemical characterization. Eur. J. Biochem. 232: 19-27
15. Marder, V. J., Mannucci, P. M., Firkin, B. G., Hoyer, L. W., Meyer, D. (1985) Standard nomenclature for factor VIII and von Willebrand factor: a recommendation by the International Committee on Thrombosis and Haemostasis. Thromb. Haemost. 54: 871-872
16. Patel, H. M. (1988) Fate of liposomes in the lymphatics. In: Gregoriadis, G. (ed.) Liposomes as Drug Carriers. John Wiley & Sons Ltd, London, pp 51-62
17. Prosser, E. (1997) New developments in protein and peptide drug delivery. Pharm. Manuf. Int. 154-156
18. Shrake, A., Finlayson, J. S., Ross, P. D. (1984) Thermal stability of human albumin measured by differential scanning calorimetry. I. Effects of caprylate and N-acetyltryptophanate. Vox Sang 47: 7-18
19. Smith, G. N., Griffiths, B., Mollison, D., Mollison, P. L. (1972) Uptake of IgG after intramuscular and subcutaneous injection. Lancet I: 1208-1212
20. Spira, J., Widlund, L., Österberg, T., Sjöström, B., Mikaelsson, M. (1995) Pharmaceutical formulation for subcutaneous, intramuscular or intradermal administration of factor VIII or factor IX. International Patent Application
21. Stutman, L. J., Dumont, A. E., Shinowara, G. Y. (1965) Coagulation factors in human lymph and plasma. Am. J. Med. Sci. 250: 292-297
22. Supersaxo, A., Heim, W. R., Steffen, H. (1990) Effect of molecular weight on the lymphatic absorption of water-soluble compunds following subcutaneous administration. Pharm. Res. 7: 167-169
23. Tsai, P. K., Volkin, D. B., Dabora, J. M., Thompson, K. C., Bruner, M. W., Gress, J. O., Matuszewska, B., Keogan, M., Bondi, J. V., Middaugh, C. R. (1993) Formulation design of acidic fibroblast growth factor. Pharm. Res. 10: 649-659
24. Yoffey, J. M., Courtice, F. C. (1970) Lymphatics, lymph and the lymphomyeloid complex. In: Yoffey, J. M., Courtice, F. C. (eds) Lymphatics, Lymph and the Lymphomyeloid Complex. Academic Press, New York, pp 295-305