Neurons in layer III of the entorhinal cortex. A role in epileptogenesis and epilepsy?

Annals of the New York Academy of Sciences

Volumn 911, Issue , 2000, Pages 328-342

  Schwarcz, Robert ^a,b   Eid, Tore ^a   Du, Fu ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b MARYLAND PSYCHIATRIC RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; AMINOOXYACETIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN NERVE CELL; CELL DEATH; CONFERENCE PAPER; ENTORHINAL CORTEX; EPILEPTOGENESIS; HIPPOCAMPUS; LIMBIC SYSTEM; NERVE EXCITABILITY; NONHUMAN; RAT; SUBICULUM; TEMPORAL LOBE EPILEPSY;

ANIMALIA;

EID: 0033942296     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06735.x     Document Type: Conference Paper

References (60)

1. 1. SOMMER, W. 1880. Erkrankung des Ammonshorns als aetiologisches Moment der Epilepsie. Arch. Psychiatr. Nervenkr. 10: 631-675.
2. 2. CLARK, L.P. & T.P. PROUT. 1903. Status epilepticus: a clinical and pathological study in epilepsy. Am. J. Insanity 60: 291-306.
3. 3. ZIMMERMAN, H.M. 1938. The histopathology of convulsive disorders of children. J. Pediatr. 13: 839-890.
4. 4. EARLE, K.M., M. BALDWIN & W. PENFIELD. 1953. Incisural sclerosis and temporal lobe seizures produced by hippocampal herniation at birth. Arch. Neurol. Psychiatry 69: 27-42.
5. 5. CAVANAGH, J.B. & A. MEYER. 1956. Aetiological aspects of Ammon's horn sclerosis associated with temporal lobe epilepsy. Br. Med. J. 2: 1403-1407.
6. 6. CORSELLIS, J.A.N. & C.J. BRUTON. 1983. Neuropathology of status epilepticus in humans. In Status Epilepticus: Mechanisms of Brain Damage and Treatment, pp. 129-139. Raven Press. New York.
7. 7. MELDRUM, B.S. & C.J. BRUTON. 1992. Epilepsy. In Greenfield's Neuropathology. Fifth edition, pp. 1246-1283. Oxford University Press. London/New York.
8. 8. WITTER, M.P. & D.G. AMARAL. 1991. Entorhinal cortex of the monkey: V. Projections to the dentate gyrus, hippocampus, and subicular complex. J. Comp. Neurol. 307: 437-459.
9. 9. INSAUSTI, R., M.T. HERRERO & M.P. WITTER. 1997. Entorhinal cortex of the rat: cytoarchitectonic subdivisions and the origin and distribution of cortical efferents. Hippocampus 7: 146-183.
10. 10. RUTECKI, P.A., R.G. GROSSMAN, D. ARMSTRONG & S. IRISH-LOEWEN. 1989. Electrophysiological connections between the hippocampus and entorhinal cortex in patients with complex partial seizures. J. Neurosurg. 70: 667-675.
11. 11. PLATE, K.H., H-G. WIESER, M.G. YASARGIL & O.D. WIESTLER. 1993. Neuropathological findings in 224 patients with temporal lobe epilepsy. Acta Neuropathol. 86: 433-438.
12. 12. SPENCER, S.S. & D.D. SPENCER. 1994. Entorhinal-hippocampal interactions in medial temporal lobe epilepsy. Epilepsia 35: 721-727.
13. 13. BERNASCONI, N., A. BERNASCONI, F. ANDERMANN, F. DUBEAU, W. FEINDEL & D.C. REUTENS. 1999. Entorhinal cortex in temporal lobe epilepsy: a quantitative MRI study. Neurology 52: 1870-1876.
14. 14. DU, F., T. EID, E.W. LOTHMAN, C. KÖHLER & R. SCHWARCZ. 1995. Preferential neuronal loss in layer III of the medial entorhinal cortex in rat models of temporal lobe epilepsy. J. Neurosci. 15: 6301-6313.
15. 15. DU, F., W.O. WHETSELL, JR., B. ABOU-KHALIL, B. BLUMENKOPF, E.W. LOTHMAN & R. SCHWARCZ. 1993. Preferential neuronal loss in layer III of the entorhinal cortex in patients with temporal lobe epilepsy. Epilepsy Res. 16: 223-233.
16. 16. EID, T., R. SCHWARCZ & O.P. OTTERSEN. 1999. Ultrastructure and immunocytochemical distribution of GABA in layer III of the rat medial entorhinal cortex following aminooxyacetic acid-induced seizures. Exp. Brain Res. 125: 463-475.
17. 17. LOTHMAN, E.W., E.H. BERTRAM, J.W. BEKENSTEIN & J.B. PERLIN. 1989. Self-sustaining limbic status epilepticus induced by "continuous" hippocampal stimulation: electrographic and behavioral characteristics. Epilepsy Res. 3: 107-119.
18. 18. SPERK, G., H. LASSMANN, H. BARAN, S.J. KISH, F. SEITELBERGER & O. HORNYKIEWICZ. 1983. Kainic acid induced seizures: neurochemical and histopathological changes. Neuroscience 10: 1301-1315.
19. 19. TURSKI, W.A., E.A. CAVALHEIRO, C. COIMBRA, M. DA PENHA BERZAGHI, C. IKONOMIDOU-TURSKI & L. TURSKI. 1987. Only certain antiepileptic drugs prevent seizures induced by pilocarpine. Brain Res. Rev. 12: 281-305.
20. 20. RIBAK, C.E., L. SERESS, P. WEBER, C.M. EPSTEIN, T.R. HENRY & R.A.E. BAKAY. 1998. Alumina gel injections into the temporal lobe of rhesus monkeys cause complex partial seizures and morphological changes found in human temporal lobe epilepsy. J. Comp. Neurol. 401: 266-290.
21. 21. DU, F., T. EID & R. SCHWARCZ. 1998. Neuronal damage after the injection of aminooxyacetic acid into the rat entorhinal cortex: a silver impregnation study. Neuroscience 82: 1165-1178.
22. 22. WITTER, M.P., A.W. GRIFFIOEN, B. JORRITSMA-BYHAM & J.L.M. KRUNEN. 1988. Entorhinal projections to the hippocampal CA1 region in the rat: an underestimated pathway. Neurosci. Lett. 85: 193-198.
23. 23. SPERK, G. 1994. Kainic acid seizures in the rat. Prog. Neurobiol. 42: 1-32.
24. 24. SLOVITER, R.S. 1983. "Epileptic" brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies. Brain Res. Bull. 10: 675-697.
25. 25. CLIFFORD, D.B., C.F. ZORUMSKI & J.W. OLNEY. 1989. Ketamine and MK-801 prevent degeneration of thalamic neurons induced by focal cortical seizures. Exp. Neurol. 105: 272-279.
26. 26. FUJIKAWA, D.G., A.H. DANIELS & J.S. KIM. 1994. The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage. Epilepsy Res. 17: 207-219.
27. 27. OLNEY, J.W., T. DEGUBAREFF & R.S. SLOVITER. 1983. "Epileptic" brain damage in rats induced by sustained electrical stimulation of the perforant path. II. Ultrastructural analysis of acute hippocampal pathology. Brain Res. Bull. 10: 699-712.
28. 28. UEKI, A., C. MIWA, K. OOHARA & K. MIYOSHI. 1996. Histological evidence for cholinergic alteration in the hippocampus following entorhinal cortex lesion. J. Neurol. Sci. 142: 7-11.
29. 29. LEVISOHN, L.F. & O. ISACSON. 1991. Excitotoxic lesions of the rat entorhinal cortex: effects of selective neuronal damage on acquisition and retention of a non-spatial reference memory task. Brain Res. 564: 230-244.
30. 30. EID, T., F. DU & R. SCHWARCZ. 1995. Differential neuronal vulnerability to aminooxyacetic acid and quinolinic acid in the rat parahippocampal region. Neuroscience 68: 645-656.
31. 31. MCMASTER, O.G., F. DU, E.D. FRENCH & R. SCHWARCZ. 1991. Focal injection of aminooxyacetic acid produces seizures and lesions in rat hippocampus: evidence for mediation by NMDA receptors. Exp. Neurol. 113: 367-374.
32. 32. BEAL, M.F., K.J. SWARTZ, B.T. HYMAN, E. STOREY, S.F. FINN & W. KOROSHETZ. 1991. Aminooxyacetic acid results in excitotoxin lesions by a novel indirect mechanism. J. Neurochem. 57: 1068-1073.
33. 33. GREENE, J.G. & J.T. GREENAMYRE. 1996. Bioenergetics and glutamate excitotoxicity. Prog. Neurobiol. 48: 613-634.
34. 34. MCMASTER, O.G., H. BARAN, H-Q. WU, F. DU, E.D. FRENCH & R. SCHWARCZ. 1993. Gamma acetylenic GABA produces axon-sparing neurodegeneration after focal injection into the rat hippocampus. Exp. Neurol. 124: 184-191.
35. 35. TATTER, S.B., W.R. GALPERN & O. ISACSON. 1995. Neurotrophic factor protection against excitotoxic neuronal death. Neuroscientist 1: 286-297.
36. 36. ZEEVALK, G.D. & W.J. NICKLAS. 1996. Attenuation of excitotoxic cell swelling and GABA release by the GABA transport inhibitor SKF 89976A. Mol. Chem. Neuropathol. 29: 27-36.
37. 37. JUNG, M.J., B. LIPPERT, B.W. METCALF, P.J. SCHECHTER, P. BÖHLEN & A. SJOERDSMA. 1977. The effect of 4-amino hex-5-ynoic acid (gamma-acetylenic GABA, gamma-ethynyl GABA), a catalytic inhibitor of GABA transaminase, on brain GABA metabolism in vivo. J. Neurochem. 28: 717-723.
38. 38. LÖSCHER, W. 1980. Effect of inhibitors of GABA transaminase on the synthesis, binding, uptake, and metabolism of GABA. J. Neurochem. 34: 1603-1608.
39. 39. ROBERTS, E. 1984. GABA-related phenomena, models of nervous system function, and seizures. Ann. Neurol. 16: S77-S89.
40. 40. DU, F. & R. SCHWARCZ. 1992. Aminooxyacetic acid causes selective neuronal loss in layer III of the rat medial entorhinal cortex. Neurosci. Lett. 147: 185-188.
41. 41. WU, H-Q. & R. SCHWARCZ. 1998. Focal microinjection of γ-acetylenic GABA into the rat entorhinal cortex: behavioral and electroencephalographic abnormalities, and preferential neuronal loss in layer III. Exp. Neurol. 153: 203-213.
42. 42. BEHR, J., T. GLOVELI & U. HEINEMANN. 1998. The perforant path projection from the medial entorhinal cortex layer III to the subiculum in the rat combined hippocampal-entorhinal cortex slice. Eur. J. Neurosci. 10: 1011-1018.
43. 43. GALLYAS, F., F.H. GULDNER, G. ZOLTAY & J.R. WOLFE. 1990. Golgi-like demonstration of "dark" neurons with an argyrophil III method for experimental neuropathology. Acta Neuropathol. 79: 620-628.
44. 44. MORGAN, J.I. & T. CURRAN. 1991. Proto-oncogene transcription factors and epilepsy. Trends Pharmacol. Sci. 12: 343-349.
45. 45. SLOVITER, R.S. & D.H. LOWENSTEIN. 1992. Heat shock protein expression in vulnerable cells of the rat hippocampus as an indicator of excitation-induced neuronal stress. J. Neurosci. 12: 3004-3009.
46. 46. SCHARFMAN, H.E. 1996. Hyperexcitability of entorhinal cortex and hippocampus after application of aminooxyacetic acid (AOAA) to layer III of the rat medial entorhinal cortex in vitro. J. Neurophysiol. 76: 2986-3001.
47. 47. KINOUCHI, H., F.R. SHARP, P.H. CHAN, J. KOISTINAHO, S.M. SAGAR & T. YOSHIMOTO. 1994. Induction of c-fos, junB, c-jun. and hsp70 mRNA in cortex, thalamus, basal ganglia, and hippocampus following middle cerebral artery occlusion. J. Cereb. Blood Flow Metab. 14: 808-817.
48. 48. DELL'ANNA, E., Y. CHEN, E. ENGIDAWORK, K. ANDERSSON, G. LUBEC, J. LUTHMAN & M. HERRERA-MARSCHITZ. 1997. Delayed neuronal death following perinatal asphyxia in rat. Exp. Brain Res. 115: 105-115.
49. 49. LEHRMANN, E., T. CHRISTENSEN, J. ZIMMER, N.H. DIEMER & B. FINSEN. 1997. Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion. J. Comp. Neurol. 386: 461-476.
50. 50. YAMAMOTO, T., S. YUKI, T. WATANABE, M. MITSUKA, K-I. SAITO & K. KOGURE. 1997. Delayed neuronal death prevented by inhibition of increased hydroxyl radical formation in transient cerebral ischemia. Brain Res. 762: 240-242.
51. 51. DENSLOW, M.J., E.W. LOTHMAN, T. EID, F. DU & R. SCHWARCZ. 1995. Hyperexcitability in area CA1 after selective lesions of layer III of the entorhinal cortex [abstract]. Soc. Neurosci. 21: 181.16.
52. 52. SCHARFMAN, H.E., J.H. GOODMAN, F. DU & R. SCHWARCZ. 1998. Chronic changes in synaptic responses of entorhinal and hippocampal neurons after entorhinal cortical cell loss produced by intracortical aminooxyacetic acid (AOAA) injection: an in vitro and in vivo study in the rat. J. Neurophysiol. 80: 3031-3046.
53. 53. KÖHLER, C. 1986. Intrinsic connections of the retrohippocampal region in the rat brain. II. The medial entorhinal area. J. Comp. Neurol. 246: 149-169.
54. 54. CABALLERO-BLEDA, M. & M.P. WITTER. 1993. Regional and laminar organization of projections from the presubiculum and parasubiculum to the entorhinal cortex: an anterograde tracing study in the rat. J. Comp. Neurol. 328: 115-129.
55. 55. EID, T., B. JORRITSMA-BYHAM, R. SCHWARCZ & M.P. WITTER. 1996. Afferents to the seizure-sensitive neurons in layer III of the medial entorhinal area: a tracing study in the rat. Exp. Brain Res. 109: 209-218.
56. 56. VAN HAEFTEN, T., F.G. WOUTERLOOD, B. JORRITSMA-BYHAM & M.P. WITTER. 1997. GABAergic presubicular projections to the medial entorhinal cortex of the rat. J. Neurosci. 17: 862-874.
57. 57. TAMMINGA, C.A., X.M. GAO, F. DU & R. SCHWARCZ. 1994. "Indirect excitotoxin" lesion of layer III in rat entorhinal cortex produces glutamate receptor changes in hippocampus [abstract]. Soc. Neurosci. 20: 213.20.
58. 58. BIZIERE, K. & J.T. COYLE. 1978. Influence of cortico-striatal afferents on striatal kainic acid neurotoxicity. Neurosci. Lett. 8: 303-310.
59. 59. KÖHLER, C., R. SCHWARCZ & K. FUXE. 1978. Perforant path transactions protect hippocampal granule cells from kainate lesion. Neurosci. Lett. 10: 241-246.
60. 60. LOTHMAN, E.W. & E.H. BERTRAM III. 1993. Epileptogenic effects of status epilepticus. Epilepsia 34: S59-S70.