Successful treatment of reactive hemophagocytic syndrome with cyclosporin A and intravenous immunoglobulin

Turkish Journal of Pediatrics

Volumn 42, Issue 2, 2000, Pages 168-170

  Erduran, Erol ^a   Gedik, Yusuf ^a   Şen, Yaşar ^a   Yildiran, Alişan ^a  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Cyclosporin A; Intravenous immunoglobulin; Reactive hemophagocytic syndrome

Indexed keywords

CYCLOSPORIN A; IMMUNOGLOBULIN G;

ARTICLE; CASE REPORT; FEMALE; FEVER; HEMOPHAGOCYTIC SYNDROME; HEPATOSPLENOMEGALY; HUMAN; MALAISE; PARTIAL THROMBOPLASTIN TIME; PROTHROMBIN TIME; SCHOOL CHILD; TREATMENT OUTCOME;

CHILD; CYCLOSPORINE; DRUG THERAPY, COMBINATION; FEMALE; HISTIOCYTOSIS, NON-LANGERHANS-CELL; HUMANS; IMMUNOGLOBULINS, INTRAVENOUS;

EID: 0033941819     PISSN: 00414301     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. nd ed) Vol.2. Pennsylvania: Lea and Febiger; 1993: 2189-2190.
2. Reiner AP, Spivak JL. Hematophagic histiocytosis: a report of 23 new patients and a review of the literature. Medicine 1988; 67: 369-388.
3. Oyama Y, Amano T, Hirakawa S, Hironaka K, Suzuki S, Ota Z. Haemophagocytic syndrome treated with cyclosporin A: a T-cell disorder? Br J Haematol 1989; 73: 276-278.
4. Imashuku S, Hibi S. Cytokines in hemophagocytic syndrome. Br J Haematol 1991; 77: 438-439.
5. Monier B, Fauroux B, Chevalier JY, et al. Miliary tuberculosis with acute respiratory failure and histiocytic hemophagocytosis: successful treatment with extracorporeal lung support and epidophyllotoxin VP-16-213. Acta Paediatr 1992; 81: 725-727.
6. Fort DW, Buchaman GR. Treatment of infection-associated hemophagocytic syndrome with immunoglobulin. J Pediatr 1994; 124: 332.
7. th ed) Vol.2. Philadelphia: W.B. Saunders Co; 1993; 1354-1374.
8. Noma T, Kou K, Yoshizawa I, et al. Monoclonal proliferation of Epstein-Barr virus-infected T-cell in a patient with virus associated hemophagocytic syndrome. Eur J Pediatr 1994: 153: 73-738.
9. Zucker JM, Cailloux JM, Vanel D, Gerard MR. Malignant histiocytosis in childhood clinical study and therapeutic in 22 cases. Cancer 1980; 45: 2821-2830.
10. Risdall RJ, McKenna RW, Nesbit ME, et al. Virus-associated hemophagocytic syndrome. A benign histiocytic proliferation distinct from malignant histiocytosis. Cancer 1979; 44: 993-1002.
11. Imashuku S, Ikushima S, Esumi N, Toda S, Saito M. Serum levels of interferon-gamma, cytotoxic factor and soluble interleukin-2 receptor in childhood hemophagocytic syndromes. Leuk Lymphoma 1991; 3: 287-292.
12. Akashi K, Hayashi S, Goudo H, et al. Involvement of interferon-γ and macrophage colony-stimulating factor in pathogenesis of haemophagocytic lymphohistiocytosis in adults. Br J Haematol 1994; 87: 243-250.
13. Yao M, Cheng AL, Su IJ, et al. Clinicopathological spectrum of haemophagocytic syndrome in Epstein-Barr virus-associated peripheral T-cell lymphoma. Br J Haematol 1994; 87: 535-543.
14. Fujiwara F, Hibi S, Imashuku S. Hypercytokinemia in hemophagocytic syndrome. Am J Pediatr Hematol Oncol 1993; 15: 92-98.
15. Imbach P, Barandum S, Cottier H, et al. Immunomodulation by intravenous immunoglobulin. Am J Pediatr Hematol Oncol 1990; 12: 134-140.
16. Watson HG, Goulden NJ, Manson LM, McDormid G, Gray JA, Parker AC. Virus-associated haemophagocytic syndrome: further evidence for T cell mediated disorder. Br J Haematol 1994; 86: 213-215.
17. Chen RL, Lin KH, Lin DT, et al. Immunomodulation treatment for childhood virus-associated haemophagocytic lymphohistiocytosis. Br J Haematol 1995; 89: 282-290.
18. Pawelec G, Rehbein A, Katrilaka K, Balko I, Busch FW. Prevention of human helper T-cell clone activation by cyclosporin A also block secretion of granulocyte/ macrophage colony stimulating activity. Immunopharmacol 1988; 16: 207-216.
19. Janka G, Imashuku S, Elindar G, Schneider M, Henter J-I. Infection-and malignancy-associated hemophagocytic syndromes. Hematol/Oncol Clin North Am 1998; 12: 435-443.