Inflated false-positive rates in Hardy-Weinberg and linkage-equilibrium tests are due to sampling on the basis of rare familial phenotypes in finite populations [3]

American Journal of Human Genetics

Volumn 67, Issue 1, 2000, Pages 258-259

  Terwilliger, J D ^a  

^a Howard Hughes Medical Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE PREDISPOSITION; GENE LOCUS; GENETIC LINKAGE; GENOME; GENOTYPE; LETTER; MARKER GENE; PHENOTYPE; PRIORITY JOURNAL; RANDOMIZATION; SYSTEM ANALYSIS;

EID: 0033941661     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302964     Document Type: Letter

References (13)

1. GA Chase Genetic linkage, gene-locus assignment, and the association of alleles with diseases Transplant Proc 9 1977 167 171
2. HW Deng WM Chen RR Recker QTL fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium at a series of linked marker loci in extreme samples of populations Am J Hum Genet 66 2000 1027 1045
3. HHH Göring JD Terwilliger Linkage analysis in the presence of errors. IV. Joint pseudomarker analysis of linkage and/or linkage disequilibrium on a mixture of pedigrees and singletons when the mode of inheritance cannot be accurately specified Am J Hum Genet 66 2000 1310 1327
4. I Hovatta T Varilo J Suvisaari JD Terwilliger V Ollikainen R Arajärvi H Juvonen A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci Am J Hum Genet 65 1999 1114 1124
5. DM Nielsen MG Ehm BS Weir Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus Am J Hum Genet 63 1999 1531 1540
6. N Risch Linkage strategies for genetically complex traits. I. Multilocus models Am J Hum Genet 46 1990 222 228
7. Terwilliger JD. On the resolution and feasibility of genome scanning approaches to unraveling the genetic components of multifactorial phenotypes. In: Rao DC, Province MA (eds) Genetic dissection of complex phenotypes: challenges for the new millennium. Academic Press, New York (in press)
8. JD Terwilliger HHH Göring Gene mapping in the 20th and 21st centuries: statistical methods, data analysis, and experimental design Hum Biol 72 2000 63 132
9. JD Terwilliger WD Shannon GM Lathrop JP Nolan LR Goldin GA Chase DE Weeks True and false positive peaks in genomewide scans: applications of length-biased sampling to linkage mapping Am J Hum Genet 61 1997 430 438
10. JD Terwilliger KM Weiss Linkage disequilibrium mapping of complex disease: fantasy or reality? Curr Opin Biotechnol 9 1998 578 594
11. KM Weiss R Chakraborty PP Majumder PE Smouse Problems in the assessment of relative risk of chronic disease among biological relatives of affected individuals J Chronic Dis 35 1982 539 551
12. Weiss KM, Terwilliger JD. How many diseases do you have to study to map one gene with SNPs? Nat Genet (in press)
13. S Zöllner A von Haeseler A coalescent approach to study linkage disequilibrium between single-nucleotide polymorphisms Am J Hum Genet 66 2000 615 628