Effects of antisense IRAK-2 oligonucleotides on PGI2 release induced by IL-1 and TNF

Acta Pharmacologica Sinica

Volumn 21, Issue 7, 2000, Pages 646-648

  Li, Yi Lei ^a   Guo, Fu Kun ^a   Wu, Shu Guang ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

Antisense oligonucleotides; Interleukin 1; Interleukin 1 receptors; Prostaglandins F; Protein kinases; Tumor necrosis factor; Vascular endothelium

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE IRAK2; PROSTACYCLIN; RECOMBINANT INTERLEUKIN 1; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PROSTAGLANDIN RELEASE; SIGNAL TRANSDUCTION;

6-KETOPROSTAGLANDIN F1 ALPHA; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; EPOPROSTENOL; HUMANS; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN KINASES; RECEPTORS, INTERLEUKIN-1; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033941421     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Endo H, Akahoshi T, Kashiwazaki S. Additive effects of IL-1 and TNF on induction of prostacyclin synthesis in human vasular endothelial cells. Biochem Biophys Res Commun 1988; 156: 1007-14.
2. O'Neil LAS, Green C. Signal transduction pathways activated by the IL-1 receptor family: ancient signaling in mammals, insects and plants. J Leukoc Biol 1998; 63: 650-7.
3. Muzio M, Ni J, Feng P, Dixit VM. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997; 278: 1612-5.
4. Minter AJ, Keoshkerian E, Chesterman CN, Dawes J. Fibroblast growth factor and heparin protect endothelial cells from the effects of interleukin 1. J Cell Physiol 1996; 167: 229-37.
5. Yamin TT, Miller DK. The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation. J Biol Chem 1997; 272: 21540-7.