Identification of a nuclear export signal in MKK6, an activator of the carp p38 mitogen-activated protein kinases

European Journal of Biochemistry

Volumn 267, Issue 14, 2000, Pages 4362-4371

  Hashimoto, Hisashi ^a   Fukuda, Makoto ^b   Matsuo, Yoshiyuki ^a   Yokoyama, Yoshihiro ^c   Nishida, Eisuke ^b   Toyohara, Haruhiko ^a   Sakaguchi, Morihiko ^a  

^a Kyoto University   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c Kobe Shoin Women's University   (Japan)

Author keywords

Fish; MAPK; MAPKK; p38; Stress activated protein kinase

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; SORBITOL;

ANIMAL CELL; ARTICLE; CARP; EPITHELIUM CELL; IMMUNOBLOTTING; NONHUMAN; NUCLEOTIDE SEQUENCE; OVARY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; BLOTTING, NORTHERN; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARPS; CELL NUCLEUS; CELLS, CULTURED; CLONING, MOLECULAR; COS CELLS; DNA, COMPLEMENTARY; ENZYME ACTIVATION; EPITHELIAL CELLS; FEMALE; GENE LIBRARY; MAP KINASE KINASE 6; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; OVALBUMIN; OVARY; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLASMIDS; PROTEIN ISOFORMS; RATS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; STRESS; TISSUE DISTRIBUTION; TRANSFECTION;

ANIMALIA; CYPRINUS CARPIO; NES;

EID: 0033939865     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01479.x     Document Type: Article

References (42)

1. 1. Nishida, E. & Gotoh, Y. (1993) The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem. Sci. 18, 128-131.
2. 2. Davis, R.J. (1994) MAPKs: new JNK expands the group. Trends Biochem. Sci. 19, 470-473.
3. 3. Lenormand, P., Sardet, C., Pages, G., L'Allemain, G., Brunet, A. & Pouyssegur, J. (1993) Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts. J. Cell Biol. 122, 1079-1088.
4. 4. Chen, R.H., Sarnecki, C. & Blenis, J. (1992) Nuclear localization and regulation of erk-and rsk-encoded protein kinases. Mol. Cell. Biol. 12, 915-927.
5. 5. Gonzalez, F.A., Seth, A., Raden, D.L., Bowman, D.S., Fay, F.S. & Davis, R.J. (1993) Serum-induced translocation of mitogen-activated protein kinase to the cell surface ruffling membrane and the nucleus. J. Cell Biol. 122, 1089-1101.
6. 6. Fukuda, M., Gotoh, I., Gotoh, Y. & Nishida, E. (1996) Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signal. J. Biol. Chem. 271, 20024-20028.
7. 7. Fischer, U., Huber, J., Boelens, W.C., Mattaj, I.W. & Luhrmann, R. (1995) The HIV-1 Rev. activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82, 475-483.
8. 8. Wen, W., Meinkoth, J.L., Tsien, R.Y. & Taylor, S.S. (1995) Identification of a signal for rapid export of proteins from the nucleus. Cell 82, 463-473.
9. 9. Wen, W., Harootunian, A.T., Adams, S.R., Feramisco, J., Tsien, R.Y., Meinkoth, J.L. & Taylor, S.S. (1994) Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal. J. Biol. Chem. 269, 32214-32220.
10. 10. Blenis, J. (1993) Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl Acad. Sci. USA 90, 5889-5892.
11. 11. Davis, R.J. (1993) The mitogen-activated protein kinase signal transduction pathway. J. Biol. Chem. 268, 14553-14556.
12. 12. Egan, S.E. & Weinberg, R.A. (1993) The pathway to signal achievement. Nature 365, 781-783.
13. 13. Cano, E. & Mahadevan, L.C. (1995) Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci. 20, 117-122.
14. 14. Raingeaud, J., Gupta, S., Rogers, J.S., Dickens, M., Han, J., Ulevitch, R.J. & Davis, R.J. (1995) Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270, 7420-7426.
15. 15. Derijard, B., Raingeaud, J., Barrett, T., Wu, I.H., Han, J., Ulevitch, R.J. & Davis, R.J. (1995) Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267, 682-685.
16. 16. Moriguchi, T., Kuroyanagi, N., Yamaguchi, K., Gotoh, Y., Irie, K., Kano, T., Shirakabe, K., Muro, Y., Shibuya, H., Matsumoto, K., Nishida, E. & Hagiwara, M. (1996) A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J. Biol. Chem. 271, 13675-13679.
17. 17. Stein, B., Brady, H., Yang, M.X., Young, D.B. & Barbosa, M.S. (1996) Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. J. Biol. Chem. 271, 11427-11433.
18. 18. Man, J., Lee, J.D., Jiang, Y., Li, Z., Feng, L. & Ulevitch, R.J. (1996) Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J. Biol. Chem. 271, 2886-2891.
19. 19. Raingeaud, J., Whitmarsh, A.J., Barrett, T., Derijard, B. & Davis, R.J. (1996) MKK3-and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol. 16, 1247-1255.
20. 20. Glise, B., Bourbon, H. & Noselli, S. (1995) hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83, 451-461.
21. 21. Tournier, C., Whitmarsh, A.J., Cavanagh, J., Barrett, T. & Davis, R.J. (1997) Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc. Natl Acad. Sci. USA 94, 7337-73342.
22. 22. Holland, P.M., Suzanne, M., Campbell, J.S., Noselli, S. & Cooper, J.A. (1997) MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous. J. Biol. Chem. 272, 24994-24998.
23. 23. Lu, X., Nemoto, S. & Lin, A. (1997) Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38. J. Biol. Chem. 272, 24751-24754.
24. 24. Lawler, S., Cuenda, A., Goedert, M. & Cohen, P. (1997) SKK4, a novel activator of stress-activated protein kinase-1 (SAPK1/JNK). FEBS Lett. 414, 153-158.
25. 25. Moriguchi, T., Toyoshima, F., Masuyama, N., Hanafusa, H., Gotoh, Y. & Nishida, E. (1997) A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses. EMBO J. 16, 7045-7053.
26. 26. Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T. & Nebreda, A.R. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78, 1027-1037.
27. 27. Hibi, M., Lin, A., Smeal, T., Minden, A. & Karin, M. (1993) Identification of an oncoprotein-and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev. 7, 2135-2148.
28. 28. Han, S.J., Choi, K.Y., Brey, P.T. & Lee, W.J. (1998) Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase. J. Biol. Chem. 273, 369-374.
29. 29. Fijan, N., Sulimanovic, D., Bearzotti, M., Muzinic, D., Zwillenberg, L.O., Chilmonczyk, S., Vautherot, J.F. & de Kinkelin, P. (1983) Some properties of the Epithelioma Papulosum Cyprini (EPC) cell line from carp Cyprinus carpio. Ann. Virol. 134, 207-220.
30. 30. Lee, J.C., Laydon, J.T., McDonnell, P.C., Gallagher, T.F., Kumar, S., Green, D., McNulty, D., Blumenthal, M.J., Heys, J.R., Landvatter, S.W., Strickler, J.E., McLaughlin, M.M., Siemens, I.R., Fischer, S.M., Livi, O.P., White, J.R., Adams, J.L. & Young, P.R. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372, 739-746.
31. 31. Han, J., Richter, B., Li, Z., Kravchenko, V. & Ulevitch, R.J. (1995) Molecular cloning of human p38 MAP kinase. Biochim. Biophys. Acta 1265, 224-227.
32. 32. Jiang, Y., Chen, C., Li, Z., Guo, W., Gegner, J.A., Lin, S. & Han, J. (1996) Characterization of the structure and function of a new mitogen-activated protein kinase (p38beta). J. Biol. Chem. 271, 17920-17926.
33. 33. Li, Z., Jiang, Y., Ulevitch, R.J. & Han, J. (1996) The primary structure of p38 gamma: a new member of p38 group of MAP kinases. Biochem. Biophys. Res. Commun. 228, 334-340.
34. 34. Brewster, J.L., de Valoir, T., Dwyer, N.D., Winter, E. & Gustin, M.C. (1993) An osmosensing signal transduction pathway in yeast. Science 259, 1760-1763.
35. 35. Tanoue, T., Adachi, M., Moriguchi, T. & Nishida, E. (2000) A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat. Cell Biol. 2, 110-116.
36. 36. Wang, X.S., Diener, K., Manthey, C.L., Wang, S., Rosenzweig, B., Bray, J., Delaney, J., Cole, C.N., Chan-Hui, P.Y., Mantlo, N., Lichenstein, H.S., Zukowski, M. & Yao, Z. (1997) Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. J. Biol. Chem. 272, 23668-23674.
37. 37. Hashimoto, H., Matsuo, Y., Yokoyama, Y., Toyohara, H. & Sakaguchi, M. (1997) Structure and expression of carp mitogen-activated protein kinases homologous to mammalian JNK/SAPK. J. Biochem. (Tokyo) 122, 381-386.
38. 38. Zheng, C.F. & Guan, K.L. (1993) Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268, 11435-11439.
39. 39. Zheng, C.F. & Guan, K.L. (1994) Cytoplasmic localization of the mitogen-activated protein kinase activator MEK. J. Biol. Chem. 269, 19947-19952.
40. 40. Dingwall, C. & Laskey, R. (1992) The nuclear membrane. Science 258, 942-947.
41. 41. Nigg, E.A. (1997) Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature 386, 779-787.
42. 42. Huang, C.J., Lee, M.S., Chang, G.D., Huang, F.L. & Lo, T.B. (1994) Molecular cloning and sequencing of a carp cDNA encoding mitogen-activated protein kinase kinase. Biochim. Biophys. Acta 1220, 223-225.