Combination chemotherapy with methotrexate, etoposide, and actinomycin D for high-risk gestational trophoblastic tumors

Gynecologic Oncology

Volumn 78, Issue 1, 2000, Pages 28-31

  Matsui, Hideo ^a   Suzuka, Kiyomi ^a   Iitsuka, Yoshinori ^a   Seki, Katsuyoshi ^a   Sekiya, Souei ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Combination chemotherapy; Gestational trophoblastic tumors; High risk; Toxicity

Indexed keywords

ANTIINFECTIVE AGENT; CYCLOPHOSPHAMIDE; DACTINOMYCIN; ETOPOSIDE; FLUOROURACIL; FOLINIC ACID; METHOTREXATE; VINCRISTINE;

ARTICLE; BLOOD TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER RECURRENCE; CANCER REGRESSION; CANCER RESISTANCE; CANCER SURVIVAL; CLINICAL ARTICLE; DRUG CHOICE; DRUG EFFICACY; FEMALE; GASTROINTESTINAL TOXICITY; HIGH RISK PATIENT; HUMAN; LEUKOPENIA; LIVER TOXICITY; NAUSEA; PRACTICE GUIDELINE; PRIORITY JOURNAL; THROMBOCYTOPENIA; TREATMENT OUTCOME; TROPHOBLASTIC TUMOR; VOMITING;

EID: 0033938650     PISSN: 00908258     EISSN: None     Source Type: Journal    
DOI: 10.1006/gyno.2000.5813     Document Type: Article

References (17)

1. Matsui H, Iitsuka Y, Seki K, Sekiya S: Comparison of chemotherapies with methotrexate, VP-16 and actinomycin-D in low-risk gestational trophoblastic disease: Remission rates and drug toxicities. Gynecol Obstet Invest 46:5-8, 1998
2. Roberts JP, Lurain JR: Treatment of low-risk metastatic gestational trophoblastic tumors with single-agent chemotherapy. Am J Obstet Gynecol 174:1917-1924, 1996
3. Soper JT, Clarke-Pearson DL, Berchuck A, Rodriguez G, Hammond CB: 5-Day methotrexate for women with metastatic gestational trophoblastic disease. Gynecol Oncol 54:76-79, 1994
4. Hammond CB, Borchert LG, Tyrey L, Creasman WT, Parker RT: Treatment of metastatic trophoblastic disease: Good and poor prognosis. Am J Obstet Gynecol 115:451-457, 1973
5. Lurain JR, Brewer JI: Treatment of high-risk gestational trophoblastic disease with methotrexate, actinomycin D, and cyclophosphamide chemotherapy. Obstet Gynecol 65:830-836, 1985
6. Mortakis AE, Braga CA: Poor prognosis metastatic gestational trophoblastic disease: The prognostic significance of the scoring system in predicting chemotherapy failures. Obstet Gynecol 76:272-277, 1990
7. Newlands ES, Bagshawe KD: Anti-tumor activity of epipodophyllin derivative VP16-213 (etoposide: NSC-141540) in gestational choriocarcinoma. Eur J Cancer 16:401-405, 1980
8. Newlands ES, Bagshawe KD, Begent RHJ, Rustin GJS, Holden L, Dent J: Developments in chemotherapy for medium- and high-risk patients with gestational trophoblastic tumours (1979-1984). Br J Obstet Gynaecol 93:63-69, 1986
9. Newlands ES, Bagshawe KD, Begent RH, Rustin GJS, Holden L: Results with the EMA/CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine) regimen in high risk gestational trophoblastic tumours, 1979 to 1989. Br J Obstet Gynaecol 98:550-557, 1991
10. Bower M, Newlands ES, Holden L, Short D, Brock C, Rustin GJS, Begent RHJ, Bagshawe KD: EMA/CO for high-risk gestational trophoblastic tumors: Results from a cohort of 272 patients. J Clin Oncol 15:2636-2643, 1997
11. Soper JT, Evans AC, Clarke-Pearson DL, Berchuck A, Rodriguez G, Hammond CB: Alternating weekly chemotherapy with etoposide-methotrexate-dactinomycin-cyclophosphamide-vincristine for high-risk gestational trophoblastic disease. Obstet Gynecol 83:113-117, 1994
12. Bolis G, Bonazzi C, Landoni F, Mangili G, Vergadoro F, Mangioni C: EMA/CO regimen in high-risk gestational trophoblastic tumor (GTT). Gynecol Oncol 31:439-444, 1988
13. Schink JC, Singh DK, Rademaker AW, Miller DS, Lurain JR: Etoposide, methotrexate, actinomycin D, cyclophosphamide, and vincristine for the treatment of metastatic, high-risk gestational trophoblastic disease. Obstet Gynecol 80:817-820, 1992
14. Quinn M, Murray J, Friedlander N, Steigrad S, Khoo S, Marsden D, Hammond I, Jobling T: EMACO in high risk gestational trophoblast disease: The Australian experience. Aust NZ J Obstet Gynaecol 34:90-92, 1994
15. Soto-Wright V, Goldstein DP, Bernstein MR, Berkowitz RS: The management of gestational trophoblastic tumors with etoposide, methotrexate, and actinomycin D. Gynecol Oncol 64:156-159, 1997
16. Sung H, Xia Z, Wu B, Wang Y: 20 years' experience in chemotherapy of choriocarcinoma and malignant mole. Chin Med J 92:677-687, 1979
17. Rustin GJS, Newlands ES, Lutz J-M, Holden L, Bagshawe KD, Hiscox JG, Foskett M, Fuller S, Short D: Combination but not single-agent methotrexate chemotherapy for gestational trophoblastic tumors increases the incidence of second tumors. J Clin Oncol 14:2769-2773, 1996