The effects of ammonia on pancreatic enzyme secretion in vivo and in vitro

Journal of Physiology and Pharmacology

Volumn 51, Issue 2, 2000, Pages 315-332

  Jaworek, J ^a   Bilski, J ^a   Jachimczak, B ^a   Cieszkowski, M ^a   Kot, M ^a   Bielanski W ^a   Konturek, S J ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Alkalization; Ammonia; Pancreatic acini; Pancreatic secretion; Plasma gastrin

Indexed keywords

AMMONIA; AMYLASE; GASTRIN; PANCREAS ENZYME;

ALKALINIZATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DOG; ENZYME ACTIVITY; ENZYME RELEASE; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PANCREAS SECRETION; RAT;

ALKALIES; AMMONIA; AMYLASES; ANIMALS; BETHANECHOL COMPOUNDS; CAERULEIN; DOGS; EATING; ENZYMES; GASTRINS; HYDROXIDES; L-LACTATE DEHYDROGENASE; PANCREAS; SODIUM HYDROXIDE;

EID: 0033938033     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983; 1: 1273.
2. Dixon MF. Pathophysiology of Helicobacter pylori infection. Scand J Gastroenterol 1994; 201: 7-10.
3. Konturek PCh, Konturek SJ, Konturek JW, Gastric secretion and the pathogenesis of peptic ulcer in the Helicobycter pylori infection. J Physiol Pharmacol 1996; 47: 5-19.
4. Raderer M, Wrba F, Kornek G, et al. Association between Helicobycter pylori infection and pancreatic cancer. Oncology 1998; 55: 16-19.
5. Marshall BJ, Barret LJ, Parakash C, McCallum RW, Guerrant RL, Urea protects Helicobacter (Campylobacter pylori) from the bacterial effect of acid. Gastroenterology 1990; 99: 697-702.
6. Megraud F, Neman-Simhu V, Brungmann D. "Further evidence of the toxic effect of toxic effect of ammonia produced by Helicobacter pylori urease on human epithelial cells". Immun. 1992, 60: 1858-1863.
7. Levi S, Beardshall K, Haddad G, Playford R, Ghosh P, Calam J. Campylobacter pylori and duodenal ulcers. The gastrin link. Lancet 1989; 1167-1168.
8. McGowan CC, Cover TL, Blaser MJ. The protein pump inhibitor omeprasole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism. Gastroenteroloy 1994; 107: 1523-1578.
9. Odum D. Petersen HD, Andersen IB, Hansen BF, Rehfeld JF. Gastrin and somatostatin in Helicobacter pylori infected antral mucosa. Gut 1994: 35: 615-618.
10. Sumi M, Summi K, Tari A, et al. Expression of antral gastrin and somatostatin mRNA in Helicobycter pylori - infected subjects. Am J Gastroenterol 1994; 89 No 9: 1515-1519.
11. Mulholland G, Ardil JE, Fillmore D, Chittajallu RS, Fullarton GM, McColl KEL. Helicobacter pylori related hypergastrinemia is the result of a selective increase in gastrin 17. Gut 1993; 34: 737-761.
12. Konturek JW, Bielański W, Konturek SJ, Domshke W. Eradication of Helicobacter pylori and gastrin-somatostatin link in duodenal ulcer patients J Pysiol Pharmacol 1996; 47: 161-175.
13. Chey WY. Hormonal control of pancreatic secretion. in: The pancreas, biology, pathology and disease, second edition by Vay Liang Go et al., Raven Pres Ltd., New York, 1993: 403-423.
14. Dominguez-Munoz JE, Glasbrenner T, Sauerbruch T, Malfertheimer P. Interdigestive pancreatic secretion and PP release are increased in asymptomatic subjects with Helicobacter pylori infection of gastric mucosa. Digestion 1995, 56: 279.
15. Walsh J. Gastrointestinal hormones: Cholecystokinin. In Physiology of Gastrointestinal Tract, Third edition, ed by LR Johnson, Raven Press New York 1994: 49-60.
16. Carter C, Rutledge PL, Steer ML, Silen W. "Secretagogue-induced changes in intracellular pH and amylase release in mouse pancreatic acini". Am J Physiol 1987, 253: G690-G696.
17. Konturek SJ, Pucher A, Radecki T. Comparison of vasoactive intestinal peptide and secretion in stimulation of pancreatic secretion. J Physiol Lond 1976; 255: 497-509.
18. Konturek SJ, Bielanski W, Solomon TE. Effects of antral mucosectomy, L-364, 718 and atropine on cephalic phase of gastric and pancreatic secretion in dogs. Gastroenterology 1990; 98: 47-55.
19. Amsterdam D. Solomon TE, Jamieson JD. Sequential dissociation of exocrine pancreas into lobules, acini and individual cells. Meth Cell Biol 1978; 20: 262-278.
20. 4 on pancreatic secretion and circulation in dogs. Am J Physiol 1988; G849-G855.
21. Bernfeld P. Amylases alpha and beta. Meth Enzymol 1955; 5: 139-148.
22. Xu JK, Goodwin S, Cooper M, Robinson J. Intracellular vacuolization caused by the urease if Helicobacter pylori. J Infect Dis 1990; 161: 1302-1304.
23. Murakami M, Saita H, Termura S et al. Gastric ammonia has a potent ulcerogenic action on the rats stomach. Gastroenterology 1993; 105: 1710-1715.
24. Tsujii M, Kawano S, Tsujii S, Fusamoto H, Sato N. Mechanism of gastric mucosal damage induced by ammonia. Gastroenterology 1992; 102: 1881-1888.
25. Imler M, Chabrier G, Simon C, Schlienger JL. Intestinal ammonium production in the rat: the role of the colon, small intestine and circulating glutamine. Res Exp Med (Berl) 1988: 1-7.
26. Saji H, Kuge Y, Yamamoto K, Magata Y, Yonekura Y, Konishi J, Yokoyama A. Accumulation of radioactivity in the pancreas after intravenous administration of [13N] ammonia. Int J Rad Appl Instrum B 1992; 19(5): 531-537.
27. Manes G, Dominguez-Munoz JE, Leodolter A, Malferthaimer P. Prevalence of Helicobacter pylori infection and gastric mucosal abnormalities in chronic pancreatitis. Am J Gastroenterol 1998; 93: 1097-1100.
28. Nieman T, Larson S, Mouritsen EA, Thorsgaard N. Helicobacter pylori infection in patients with chronic pancreatitis and duodenal ulcer. Scand J Gastroenterol 1997; 32: 1201-1203.
29. Le Borgne J, Partensky Ch, Chavaillon A. "Inhibitory effect of vacuolating toxin of Helicobacter pylori on enzyme secretion from rat pancreatic acini" Pancreas, 1999, (8(3): 324-327.
30. Kohler E, Beglinger C, Eysselein V, Grotzinger U, Gyr K. Gastrin is not a physiological regulator of pancreatic enzyme secretion in the dog. Am J Physiol 1987; 252: G40-G44.
31. + antiport in guinea pig pancreatic acini" FEEBS Lett 1995; 187: 126-130.
32. Burnham DB, Munowitz P, Hootman SR, Williams JA. Regulation of protein phosphorylation in pancreatic acini. Biochem J 1986; 235: 125-131.
33. Gardner JD, Jensen RT. Receptors on pancreatic acinar cells. In: The pancreas; biology, pathology and disease. Second edition, ed by Vay Liang, W. Go et al. Raven Press Ltd., New York 1993; 151-166.