Corticosteroids and interferons inhibit cytokine-induced production of IL-8 by human endothelial cells

Cytokine

Volumn 12, Issue 4, 2000, Pages 355-360

  Nyhlén, Kristina ^a   Linden, Margareta ^b   Andersson, Rolf ^a   Uppugunduri, Srinivas ^a,c  

^a LINKÖPING UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cytokines; HUVEC; IL 8; Interferons; Steroids

Indexed keywords

BUDESONIDE; CORTICOSTEROID; DEXAMETHASONE; INTERFERON; INTERLEUKIN 8; MONENSIN; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EFFECT; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; UMBILICAL VEIN;

EID: 0033937970     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1006/cyto.1999.0557     Document Type: Article

References (18)

1. Devalaraja MA, Richmond A. Multiple chemotactic factors: fine control or redundancy? TiPS. 20:1999;151-156.
2. Wells TNC, Power CA, Proudfoot AEI. Definition, function and pathophysiological significance of chemokine receptors. Trends Pharm Sci. 19:1998;376-380.
3. McFadden G, Kelvin D. New strategies for chemokine inhibition and modulation. Biochem Pharmacol. 54:1997;1271-1280.
4. Lukacs NW, Strieter RM, Elner V, Evanoff HL, Burdick MD, Kunkel SL. Production of chemokines, interleukin-8 and monocyte chemoattractant protein-1 during monocyte:endothelial interactions. Blood. 86:1995;2767-2773.
5. Rot A, Hub E, Middleton J, Pons F, Rabeck C, Thirer K, Wintle J, Wolff B, Zsak M, Dukor P. Some aspects of Il-8 pathophysiology. III: Chemokine interaction with endothelial cells. J Leukoc Biol. 59:1996;39-44.
6. Wolff B, Zsak M, Rabeck C. Immunofluorescence assay for the quantitative and qualitative evaluation of intracellular interleukin-8 in microtiter plates. Anal Biochem. 244:1997;33-39.
7. Strindhall J, Lundblad A, Påhlsson P. Interferon-γ enhancement of E-selectin expression on endothelial cells is inhibited by monensin. Scand J Immunol. 46:1997;338-343.
8. Oliveira I, Sciavolino PJ, Lee TH, Vilcek J. Downregulation of IL-8 gene expression in human fibroblasts: Unique mechanism of transcriptional inhibition by interferon. Proc Natl Acad Sci U S A. 89:1992;9049-9053.
9. Schnyder-Candrian S, Strieter R, Kunkel S, Walz A. Interferon-α and interferon-γ down-regulate the production of interleukin-8 and ENA-78 in human monocutes. J Leukoc Biol. 57:1995;929-935.
10. Taylor JL, Grossberg S. The effects of interferon-alpha on the production and action of other cytokines. Semin Oncol. 25:1998;23-29.
11. Wiegers GJ, Reul JMHM. Induction of cytokine receptors by glucocorticosteroids: functional and pathological significance. TiPS. 19:1998;317-321.
12. Marfaing-Koka A, Devergne O, Gorgone G, Portier A, Schall T, Galanaud P, Emilie D. Regulation of the production of the RANTES chemokine by endothelial cells. J Immunol. 154:1995;1870-1878.
13. Melrose J, Tsurushita N, Liu G, Berg EL. IFN-γ inhibits activation-induced expression of E- and P-selectin on endothelial cells. J Immunol. 161:1998;2457-2464.
14. Mukaida, N, Morita, M, Ishikawa, Y, Rice, N, Okamoto, S, Kasahara, T, Matsushima, K, Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression, J Biol Chem, 6;269, 13289, 95.
15. Franchimont D, Louis E, Dewew W, Martens H, Vrindts-Gevaert Y, De Groote D, Belaiche J, Geenen V. Effects of dexamethasone on the profile of cytokine secretion in human whole blood cell cultures. Regulatory Peptides. 73:1998;59-65.
16. Roger T, Out TA, Mukaida N, Matsushimas K, Jansen HK, Lutter R. Enhanced AP-1 and NFkB activities and stability of interleukin-8 (IL-8) transcripts are implicated in IL-8 mRNA superinduction in lung epithelial H292 cells. Biochem J. 330:1998;429-435.
17. Cassatella M, Gaperini S, Calzetti F, McDonald P, Trinchieri G. Lipopolysaccharide-induced interleukin-8 gene expression in human granulocytes: transcriptional inhibition by interferon-gamma. Biochem J. 310:1995;751-755.
18. Meda L, Gasperini S, Ceska M, Cassatella M. Modulation of proinflammatory cytokine release from human polymorphonuclear leukocytes by gamma interferon. Cell Immunol. 157:1994;448-461.