Dihydroniphimycin: New polyol macrolide antibiotic produced by Streptomyces hygroscopicus 15. Isolation and structure elucidation

Journal of Antibiotics

Volumn 53, Issue 6, 2000, Pages 627-632

  Ivanova, Veneta ^a   Gesheva, Victoria ^a   Kolarova, Mariana ^a  

^a INSTITUTE OF MICROBIOLOGY   (Bulgaria)

Author keywords

[No Author keywords available]

Indexed keywords

AK 15 2; DIHYDRONIPHIMYCIN; MACROLIDE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM CULTURE; COLUMN CHROMATOGRAPHY; DRUG ISOLATION; DRUG STRUCTURE; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; GEL CHROMATOGRAPHY; MYCELIUM; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY; STREPTOMYCES GRISEUS;

STREPTOMYCES HYGROSCOPICUS;

EID: 0033937653     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.53.627     Document Type: Article

References (18)

1. IVANOVA, V.; V. GESHEVA, R. GESHEVA, V. LYUBENOVA & P. PANAYOTOV: Isolation, purification and separation of polyether antibiotic complex IM-15 from Streptomyces sp. 15. Acta Microbiolog. Bulg. 22: 61-67, 1988
2. GESHEVA, V.; R. GESHEVA, V. IVANOVA & P. PANAYOTOV: Taxonomy of Streptomyces hygroscopicus 15, producer of an antibiotic complex. Compt. Rend. Acad. Bulg. Sci. 41: 53-56, 1988
3. IVANOVA, V.; V. LYUBENOVA, V. GESHEVA & R. GESHEVA: Non-polyenic macrolide antibiotic and method for production. Bulg. Patent 501-06, C 12 P 1/06, 1992
4. STEPHAN, H.; C. KEMPTER, J. W. METZGER, G. JUNG, O. POTTERAT, C. PFEFFERLE & H-P. FIEDLER: Kanchanamycins, new polyol macrolide antibiotics produced by Streptomyces olivaceus Tu 4018. II. Structure elucidation. J. Antibiotics 49: 765-769, 1996
5. FUKUSHIMA, K.: T. ARAI, S. IWASAKI, M. NAMIKOSHI & S. OKUDA: Studies on macrocyclic lactone antibiotics. VI. Skeletal structure of copiamycin. J. Antibiotics 35: 1480-1494, 1982
6. KOSHINO, H.; K. KOBINATA, J. UZAWA, M. URAMATO, K. ISONO & H. OSADA: Structure of malolactomycins A and B, novel 40-membered macrolide antibiotics. Tetrahedron 49: 8827-8836, 1993
7. KUMAZAWA, S.; Y. ASAMI, K. AWANE, H. OHTANI, C. FUKUCHI, T. MIKAWA & T. HAYASE: Structural studies of new macrolide antibiotics, shurimycins A and B. J. Antibiotics 47: 688-696, 1994
8. IWASAKI, S.; M. NAMIKOSHI, K. SASAKI, K. FUKUSHIMA & S. OKUDA: Studies on macrocyclic lactone antibiotics. V. The structures of azalomycins F3a and F5a. Chem. Pharm. Bull. 30: 4006-4014, 1982
9. BASSI, L.; B. JOOS, P. GASSMANN, H-P. KAISER, H. LEUENBERGER & W. KELLER-SCHIERLEIN: Versuche zur Strukturaufklarung von Niphimycin Reinigung und Charakterisierung der Niphimycine I und sowie Abbau mit Salpetersaure. Helv. Chim. Acta 66: 92-117, 1983
10. KELLER-SSCHIRLEIN, W.; B. JOOS, H-P. KAISER & P. GASSMANN: Versuche zur Strukturaufklarung von Niphimycin. 2. Die Konstitution von Desmalonylniphimycin. Helv. Chim. Acta 66: 226-258, 1983
11. GASSMANN, P.; L. HAGMANN, W. KELLER-SCHIERLEIN & D. SAMAIN: Versuche zur Strukturaufklarung von Niphimycin. 3. Identitat von Scopaufungin mit Niphimycin I und Lage des Malonylreste in Niphimycin und Copiamycin. Helv. Chim. Acta 67: 696-705, 1984
12. HAMMAN, P.; S. GRABLEY, W. RAETHER, B. CLOMMER, H. KLUGE & B. SACHSE: Verfahren zur Herstellung der Desmalonylverbindung von Makrolid-Lactonen. European patent 0 272 667 A2, 1986
13. GRABLEY, S.; P. HAMMANN, W. RAETHER, J. WINK & A. ZEECK: Secondary metabolites by chemical screening. II. Amycins A and B, two novel niphimycin analogs isolated from a high producer strain of elaiophylin and nigericin. J. Antibiotics 43: 639-647, 1990
14. TAKESAKO, K. & T. BEPPU: Studies on new antifungal antibiotics, guanidylfungins A and B. II. Structure elucidation and biosynthesis. J. Antibiotics 37: 1170-1186, 1984
15. SAMAIN, D.; J. C. COOK, Jr. & K. L. RINEHART, Jr.: Structure of scopafungin, a potent nonpolyene antifungal antibiotic. J. Am. Chem. Soc. 104: 4129-4141, 1982
16. UBUKATA, M.; N. SHIRAISHI, K. KOBINATA, T. KUDO, I. YAMAGUCHI, H. OSADA, Y-C. SHEN & K. ISONO: RS-22A, B and C: New macrolide antibiotics from Streptomyces violaceusniger I. Taxonomy, fermentation, isolation and biological activities. J. Antibiotics 48: 289-292, 1995
17. UBUKATA, M.; T. MORITA & H. OSADA: RS-22A, B and C: New macrolide antibiotics from Streptomyces violaceusniger II. Physico-chemical properties and structure elucidation. J. Antibiotics 48: 293-299, 1995
18. IVANOVA, V. & A. GUSHTEROVA: Malonylniphimycin: Macrolide antibiotic from Streptomyces hygroscopicus B-7. Physico-chemical properties and structure elucidation. J. Antibiotics 50: 965-969, 1997