Post-mortem studies of brain phosphatidylinositol hydrolysis in depression and the effect of antidepressant treatment

International Journal of Neuropsychopharmacology

Volumn 3, Issue 2, 2000, Pages 109-115

  Coull, Moyra A ^a   Lowther, Sandra ^a   Katona, Cornelius L E ^b   Horton, Roger W ^a  

^a ST GEORGE S HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antidepressant drugs; Depression; Phosphatidylinositol hydrolysis; Post mortem human brain; Signal transduction; Suicide

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; ACETYLSALICYLIC ACID; AMITRIPTYLINE; AMOXAPINE; ANTIDEPRESSANT AGENT; BARBITURIC ACID DERIVATIVE; CLOMIPRAMINE; DEXTROPROPOXYPHENE; DIAZEPAM; DOSULEPIN; FLUPENTIXOL; GUANINE NUCLEOTIDE BINDING PROTEIN; HALOPERIDOL; IMIPRAMINE; LITHIUM; LOFEPRAMINE; MIANSERIN; NEUROTRANSMITTER; NITRAZEPAM; PARACETAMOL; PHOSPHATIDYLINOSITOL; PROCYCLIDINE; SEROTONIN; TEMAZEPAM; THIORIDAZINE; TRANYLCYPROMINE; TRIFLUOPERAZINE; TRIMIPRAMINE;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; FEMALE; HUMAN; HUMAN TISSUE; HYDROLYSIS; MALE; NEUROTRANSMISSION; PHOSPHOINOSITIDE METABOLISM; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUICIDE; VIOLENCE;

EID: 0033937258     PISSN: 14611457     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1461145700001851     Document Type: Article

References (14)

1. Beskovv J, Gottfries CG, Roos BE, Winblad B (1976). Determination of monoamines and monoamine metabolites in the human brain: post-mortem studies in a group of suicides and in a control group. Acta Psychiatrica Scandinavica 53, 7-20.
2. Bland M (1995). An Introduction to Medical Statistics (pp. 144-146). Oxford: Oxford Medical Publications.
3. 2 receptor binding sites in depressed suicide victims. Brain Research 443, 272-280.
4. Greenwood AF, Powers RE, Jope RS (1995). Phosphoinositide hydrolysis, Gαq, phospholipase C, and protein kinase C in post mortem human brain: effects of post mortem interval, subject age, and Alzheimer's disease. Neuroscience 69, 125-138.
5. Jope RS, Song L, Li PP, Young LT, Kish SJ, Pacheco MA, Warsh JJ (1996). The phosphoinositide signal transduction system is impaired in bipolar affective disorder. Journal of Neurochemistry 66, 2402-2409.
6. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265-275.
7. 2 receptors in suicide victims: violence of death, depression and effects of antidepressant treatment. Brain Research 642, 281-289.
8. Mikuni M, Kusumi I, Kagaya A, Kuroda Y, Mori H, Takahashi K (1991). Increased 5-HT-2 receptor function as measured by serotonin-stimulated phosphoinositide hydrolysis in platelets of depressed patients. Progress in Neuro-Psychopharmacology and Biological Psychiatry 15, 49-61.
9. Mori H, Koyama T, Yamashita I (1991). Platelet alpha-2 adrenergic receptor-mediated phosphoinositide responses in endogenous depression. Life Sciences 48, 741-748.
10. Pacheco MA, Stockmeier C, Meltzer HY, Overholser JC, Dilley GE, Jope RS (1996). Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain. Brain Research 723, 37-45.
11. Pandey SC, Davis JM, Schwertz DW, Pandey GN (1991). Effect of antidepressants and neuroleptics on phosphoinositide metabolism in human platelets. Journal of Pharmacological and Experimental Therapeutics 256, 1010-1018.
12. 1 protein in the prefrontal cortex of teenage suicide subjects. American Journal of Psychiatry 156, 1895-1901.
13. Rehavi M, Jerushalemi Z, Aviv A, Laor N, Podliszeski E, Karp L, Shavit S, Weizman R (1993). Interaction between antidepressants and phosphoinositide signal transduction system in human platelets. Biological Psychiatry 33, 40-44.
14. Wallace MA, Claro E (1993). Transmembrane signaling through phospholipase C in human cortical membranes. Neurochemical Research 18, 139-145.