Polystyrene microsphere spray standards based on CFC-free inhaler technology

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 13, Issue 2, 2000, Pages 105-115

  Vervaet, Chris ^a,b   Byron, Peter R ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

Aerosol calibration standards; HFA 134a; Metered dose inhalers; Polystyrene microspheres

Indexed keywords

CHLOROFLUOROCARBON; POLYSTYRENE;

AEROSOL; ARTICLE; CALIBRATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; METERED DOSE INHALER; PARTICLE SIZE; SOLUBILITY;

EID: 0033936845     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/089426800418631     Document Type: Article

References (13)

1. Berglund, R.N., and B.Y.H. Liu. 1973. Generation of monodisperse aerosol standards. Environ. Sci. Technol. 7:147-153.
2. Mitchell, J.P., K.W. Snelling, and R.L. Stone. 1987. Improvements to the vibrating orifice aerosol generator. J. Aerosol Sci. 18:231-243.
3. Chen, B.T. 1993. Instrument calibration. In W. Willeke, and P.A. Baron, eds. Aerosol Measurement: Principles, Techniques and Applications. Van Nostrand Reinhold, New York, 493-520.
4. Raabe, O.G. 1968. The dilution of monodisperse suspensions for aerosolization. Am. Ind. Hyg. Assoc. J. 29:439-443.
5. Horton K.D., and J.P. Mitchell. 1992. Development of a number concentration standard for micron-sized particles. J. Aerosol Sci. 23(suppl. 1):S341-344.
6. Byron, P.R. 1990. Aerosol formulation, generation and delivery using metered dose inhalers. In P.R. Byron, ed. Respiratory Drug Delivery. CRC Press, Boca Raton, FL, 167-205.
7. Vervaet, C., and P.R. Byron. Drug-surfactant-propellant interactions in HFA-formulations. Int. J. Pharm. 186:13-30.
8. Byron, P.R. 1994. Dosing reproducibility from experimental albuterol suspension metered-dose inhalers. Pharm. Res. 11:580-584.
9. Brown, W.E. 1990. Polystyrene. In I.I. Rubin, ed. Handbook of Plastic Materials and Technology. J. Wiley and Sons, New York, 459-485.
10. Gonda I. 1985. Development of a systematic theory of suspension inhalation aerosols. I. A framework to study the effects of aggregation on the aerodynamic behaviour of drug particles. Int. J. Pharm. 27:99-116.
11. Chan, H.K., and I. Gonda. 1988. Development of a systematic theory of suspension inhalation aerosols. II. Aggregates of monodisperse particles nebulized in polydisperse droplets. Int. J. Pharm. 41:147-157.
12. Thornburg, J., S.J. Cooper, and D. Leith. 1999. Counting efficiency of the API Aerosizer. J. Aerosol Sci. 30:479-488.
13. Oskouie, A.K., H-C Wang, R. Mavliev, and K.E. Noll. 1998. Calculated calibration curves for particle size determination based on time-of-flight (TOF). Aerosol Sci. Technol. 29:433-441.