The carbohydrate metabolism of Fasciola hepatica, example of biochemical adaptations in parasitic helminths

Acta Parasitologica

Volumn 45, Issue 2, 2000, Pages 59-66

  Tielens, Aloysius G M ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Bioenergetics; Electron transport chain; Energy metabolism; Fasciola hepatica; Fumarate reductase; Rhodoquinone

Indexed keywords

EID: 0033936741     PISSN: 12302821     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (35)

1. Ackrell B. A. C., Johnson M. K., Gunsalus R. P., Cecchini G. 1992. Structure and function of succinate dehydrogenase and fumarate reductase. In: Chemistry and biochemistry of flavoenzymes. Vol. III: Structure and function of succinate dehydrogenase and fumarate reductase (Ed. F. Muller). CRC Press, Boca Raton, USA, 229-297.
2. Allen P. C. 1973. Helminths: comparison of their rhodoquinone. Experimental Parasitology, 34, 211-219.
3. Amino H., Wang H., Hirawake H., Saruta F., Mizuchi D., Mineki R., Shindo N., Murayama K., Takamiya S., Aoki T., Kojima S., Kita K. 2000. Stage-specific isoforms of Ascaris suum complex II: the fumarate reductase of the parasitic adult and the succinate dehydrogenase of free-living larvae share a common iron-sulfur subunit. Molecular and Biochemical Parasitology, 106, 63-76.
4. Barrett J., Coles G. C., Simpkin K. G. 1978. Pathways of acetate and propionate production in adult Fasciola hepatica. International Journal for Parasitology, 8, 117-123.
5. Berens R. L., Krug E. C., Marr J. J. 1995. Purine and pyrimidine metabolism. In: Biochemistry and molecular biology of parasites (Eds. J. J. Marr and M. Müller). Academic Press, London, 89-117.
6. Chen G. Z., Bennett J. L. 1993. Characterization of mevalonate-labeled lipids isolated from parasite proteins in Schistosoma mansoni. Molecular and Biochemical Parasitology, 59, 287-292.
7. Foster J. M., Pennock J. F., Marshall I., Rees H. H. 1993. Biosynthesis of isoprenoid compounds in Schistosoma mansoni. Molecular and Biochemical Parasitology, 61, 275-284.
8. Hägerhall C., Hederstedt L. 1996. A structural model for the membrane-integral domain of succinate:quinone oxidoreductases. FEBS Letters, 389, 25-31.
9. Hederstedt L., Ohnishi T. 1992. Progress in succinate:quinone oxidoreductase research. In: Molecular mechanisms in bioenergetics (Ed. L. Ernster). Elsevier, Amsterdam, 163-198.
10. Humiczewska M. 1975. Oxidative enzymes in the development of Fasciola hepatica L. II. Dehydrogenase activity of miracidium. Folia Histochemica et Cytochemica, 13, 37-50.
11. Kita K. 1992. Electron-transfer complexes of mitochondria in Ascaris suum. Parasitology Today, 155-159.
12. Klingbeil M. M., Walker D. J., Arnette R., Sidawy E., Hayton K., Komuniecki P. R., Komuniecki R. 1996. Identification of a novel dihydrolipoyl dehydrogenase-binding protein in the pyruvate dehydrogenase complex of the anaerobic parasitic nematode, Ascaris suum. Journal of Biological Chemistry, 271, 5451-5457.
13. Köhler P., Bryant C., Behm C. A. 1978. ATP synthesis in a succinate decarboxylase system from Fasciola hepatica mitochondria. International Journal for Parasitology, 8, 399-404.
14. Lloyd G. M. 1986. Energy metabolism and its regulation in the adult liver fluke, Fasciola hepatica. Parasitology, 93, 217-248.
15. Mansour T. E. 1959. Studies on the carbohydrate metabolism of the liver fluke, Fasciola hepatica. Biochimica et Biophysica Acta, 34, 456-464.
16. Nakamura K., Yamaki M., Sarada M., Nakayama S., Vibat C. R. T., Gennis R. B., Nakayashiki T., Inokuchi H., Kojima S., Kita K. 1996. Two hydrophobic subunits are essential for the heme b ligation and functional assembly of complex II (succinate-ubiquinone oxidoreductase) from Escherichia coli. Journal of Biological Chemistry, 271, 521-527.
17. North M. J., Lockwood B. C. 1995. Amino acid and protein metabolism. In: Biochemistry and molecular biology of parasites (Eds. J. J. Marr and M. Müller). Academic Press, London, 67-88.
18. Oldenborg V., Vugt F. van, Golde L. M. G. van 1975. Composition and metabolism of phospholipids of Fasciola hepatica, the common liver fluke. Biochimica et Biophysica Acta, 398, 101-110.
19. Pietrzak S. M., Saz H. J. 1981. Succinate decarboxylation to propionate and the associated phosphorylation in Fasciola hepatica and Spirometra mansonoides, Molecular and Biochemical Parasitology, 3, 61-70.
20. Roos M. H., Tielens A. G. M. 1994. Differential expression of two succinate dehydrogenase subunit-B genes and a transition in energy metabolism during the development of the parasitic nematode Haemonchus contortus. Molecular and Biochemical Parasitology, 66, 273-281.
21. Saruta F., Kuramochi T., Nakamura K., Takamiya S., Yu Y., Aoki T., Sekimizu K., Kojima S., Kita K. 1995. Stage-specific isoforms of complex II (succinate-ubiquinone oxidoreductase) in mitochondria from the parasitic nematode Ascaris suum. Journal of Biological Chemistry, 270, 928-932.
22. Saz H. J., DeBruyn B., De Mata Z. 1996. Acyl-CoA transferase activities in homogenates of Fasciola hepatica adults. Journal of Parasitology, 82, 694-696.
23. Smith A. M., Dowd A. J., McGonigle S., Keegan P. S., Brennan G., Trudgett A., Dalton J. P. 1993. Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica. Molecular and Biochemical Parasitology, 62, 1-8.
24. Tielens A. G. M. 1994. Energy generation in parasitic helminths. Parasitology Today, 10, 346-352.
25. Tielens A. G. M., Heuvel J. M. van den, Bergh S. G. van den 1984. The energy metabolism of Fasciola hepatica during its development in the final host. Molecular and Biochemical Parasitology, 13, 301-307.
26. Tielens A. G. M., Heuvel J. M. van den, Bergh S. G. van den 1987. Differences in intermediary energy metabolism between juvenile and adult Fasciola hepatica. Molecular and Biochemical Parasitology, 24, 273-281.
27. Tielens A. G. M., Meer P. van der, Bergh S. G. van der 1981. The aerobic energy metabolism of the juvenile Fasciola hepatica. Molecular and Biochemical Parasitology, 3, 205-214.
28. Trembacz H., Jezewska M. M. 1998. Adenine nucleoside phosphorylases in trematode Fasciola hepatica, the mammalian parasite. Advances in Experimental Medical Biology, 431, 711-717.
29. Van Hellemond J. J., Klockiewicz M., Gaasenbeek C. P., Roos M. H., Tielens A. G. M. 1995. Rhodoquinone and complex II of the electron transport chain in anaerobically functioning eukaryotes. Journal of Biological Chemistry, 270, 31065-31070.
30. Van Hellemond J. J., Luijten M., Flesch F. M., Gaasenbeek C. P. H., Tielens A. G. M. 1996. Rhodoquinone is synthesized de novo by Fasciola hepatica. Molecular and Biochemical Parasitology, 82, 217-226.
31. Van Hellemond J. J., Opperdoes F. R., Tielens A. G. M. 1998. Trypanosomatidae produce acetate via a mitochondrial acetate:succinate CoA transferase. Proceedings of the National Academy of Sciences U.S.A., 95, 3036-3041.
32. Van Hellemond J. J., Tielens A. G. M. 1994. Expression and functional properties of fumarate reductase. Biochemical Journal, 304, 321-331.
33. Vugt F. van, Meer P. van der, Bergh S. G. van den 1979. The formation of propionate and acetate as terminal processes in the energy metabolism of the adult liver fluke, Fasciola hepatica. International Journal of Biochemistry, 10, 11-18.
34. Wissenbach U., Ternes D., Unden G. 1992. An Escherichia coli mutant containing only demethylmenaquinone, but no menaquinone: effects on fumarate, dimethylsulfoxide, trimethylamine N-oxide and nitrate respiration. Archives of Microbiology, 158, 68-73.
35. Yamasaki H., Kominami E., Aoki T. 1992. Immunocytochemical localisation of a cysteine protease in adult worms of the liver fluke Fasciola sp. Parasitology Research, 78, 574-580.