Elevated cardiac troponin levels do not predict adverse outcomes in hospitalized patients without clinical manifestations of acute coronary syndromes

Cardiology

Volumn 93, Issue 1-2, 2000, Pages 1-6

  Barasch, Eddy ^a,b,d   Kaushik, Vinod ^a,b   Gupta, Richa ^a,b   Ronen, Pinky ^c   Hartwell, Beth ^a,b  

^a UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^b MEMORIAL HERMANN HOSPITAL   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

Cardiac; Prognostic value; Troponins

Indexed keywords

TROPONIN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; DISEASE EXACERBATION; DISEASE MARKER; ELECTROCARDIOGRAPHY; FEMALE; HEART MUSCLE ISCHEMIA; HUMAN; MALE; PRIORITY JOURNAL; PROGNOSIS; THORAX PAIN;

EID: 0033936218     PISSN: 00086312     EISSN: None     Source Type: Journal    
DOI: 10.1159/000006994     Document Type: Article

References (43)

1. Adams JE III, Bodor GS, Davila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS: Cardiac troponin I: A marker with high specificity for myocardial injury. Circulation 1993; 88:101-106.
2. Wu AHB, Valdes R, Apple FS, Gornet T, Stone MA, Mayfield-Stokes S, Ingersoll-Stroubos AM, Wiler B: Cardiac troponin T immunoassay for diagnosis of myocardial infarction. Clin Chem 1994;40:900-907.
3. Hamm CW: New serum markers for acute myocardial infarction. N Engl J Med 1994;331: 607-608.
4. Ravkilde J, Nissen H, Hoeder M, Tygesen K: Independent prognostic value of serum creatine kinase isoenzyme MB mass, cardiac troponin T, and myosin light chain levels in suspected acute myocardial infarction. J Am Coll Cardiol 1995;25:574-581.
5. Antman EM, Tanasijevic MJ, Thompson B, Schactman M, McCabe CH, Cannon CP, Fischer GA, Fung AY, Thompson C, Wybenga D. Braunwald E: Cardiac-specific troponin I predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 1996; 335:1342-1349.
6. Luscher MS, Thygesen K, Raiacvkilde J, Heickendorff A: Applicability of cardiac troponin T and I for early risk stratification in unstable coronary artery disease. Circulation 1997;96:2578-2585.
7. Falk E: Unstable angina with fatal outcome: Dynamic coronary thrombosis leading to infarction and/or sudden death: Autopsy evidence of recurrent mural thrombosis with peripheral embolization culminating in total vascular occlusion. Circulation 1985;71:699-708.
8. Apple FS, Sharkey SW, Hoeft P, Skeate R, Voss E, Dahlmeier BA, Preese LM: Prognostic value of serum cardiac troponin I and T in chronic dialysis patients: A 1-year outcome analysis. Am J Kidney Dis 1997;29:399-403.
9. Musso P, Cox I, Vidano E, Zambon D, Panteghini M: Cardiac troponin elevations in chronic renal failure: Prevalence and clinical significance. Clin Biochem 1999;32/2:125-130.
10. McLaurin MD, Apple FS, Falahati A, Murakami MM, Miller EA, Sharkey SW: Cardiac troponin I and creatine kinase-MB mass to rule out myocardial injury in hospitalized patients with renal insufficiency. Am J Cardiol 1998;82: 973-975.
11. Collinson PO, Hadcocks L, Foo Y, Rosalki SB, Stubbs PJ, Morgan SH, O'Donnell J: Cardiac troponins in patients with renal dysfunction. Ann Clin Biochem 1998;35:380-386.
12. Ishii J, Ishikawa T, Yukitake J, Nagamura Y, Ito M, Wang JH, Kato Y, Hiramitsu S, Inoue S, Kondo T, Morimoto S, Nomura M, Watanabe Y, Hishida H: Clinical specificity of a second-generation cardiac troponin T assay in patients with chronic renal failure. Clin Chim Acta 1998;270/2:183-188.
13. Lindhal B, Venge P, Wallentin L: Troponin T identifies patients with unstable coronary artery disease who benefit from long-term anti-thrombotic protection. J Am Coll Cardiol 1997;29:43-48.
14. Lopez-Jimenez F, Goldman L, Sacks BD, Thomas EJ, Johnson PA, Cook EF, Lee HL: Prognostic value of cardiac troponin T after noncardiac surgery: 6-month follow-up data. J Am Coll Cardiol 1997;29:1241-1245.
15. Bonnefoy E, Filley S, Kirkorian G, Guidollet J, Roriz R, Robin J, Touboul P: Troponin I, troponin T, or creatine kinase-MB to detect perioperative myocardial damage after coronary artery bypass surgery. Chest 1998;114:482-486.
16. Gensini GF, Fusi C, Conti AA, Calami GC, Montesi GF, Galanti G, Noferi D, Carbonetto F, Palmarini MF, Abbate R, Vaccari M: Cardiac troponin I and Q-wave myocardial infarction after coronary artery bypass surgery. Crit Care Med 1998;26:1986-1990.
17. Ferjani M, Droc G, Dreux S, Arthaud M, Goarin J-P, Roiou B, Coriat P: Circulating cardiac troponin T in myocardial contusion. Chest 1997;111:427-433.
18. Raderer M, Kornek G, Weinlander G, Kastner J: Serum troponin T levels in adults undergoing anthracycline therapy. J Natl Cancer Inst 1997; 89:171.
19. Lauer B, Niederau C, Kuhl U, Schannwell M, Pauschinger M, Strauer BE, Schultheiss HP: Cardiac troponin T in patients with clinically suspected myocarditis. J Am Coll Cardiol 1997;30:1354-1359.
20. Smith SC, Ladenson JH, Mason JW, Jaffe AS: Elevations of cardiac troponin I associated with myocarditis. Experimental and clinical correlates. Circulation 1997;95/1:163-168.
21. Missov E, Calzolari C, Pau B: Circulating cardiac troponin I in severe congestive heart failure. Circulation 1997;96:2953-2958.
22. Missov E, Mair J: A novel biochemical approach to congestive heart failure: Cardiac troponin T. Am Heart J 1999;138/1:95-99.
23. Sabin Z, Nassar R, Ungerleider RM, Oakley AE, Anderson PAW: Cardiac troponin T isoforms expression correlates with pathophysiological descriptors in patients who underwent corrective surgery for congenital heart disease. Circulation 1996;94:472-476.
24. Bodor GS, Survant L, Voss E, Smith S, Apple FS: Cardiac troponin I is not expressed in fetal and healthy or diseased adult human skeletal muscle. Clin Chem 1997;43:476-483.
25. Brscic E, Chiappino I, Bergerone S, Lanfranco G, Mainardi L, Imazio M, Amellone C, Pagni R, Rosettani E: Prognostic implications of detection of troponin I in patients with unstable angina pectoris. Am J Cardiol 1998;82:971-973.
26. Willging S, Keller F, Steinbach G: Specificity of cardiac troponins I and T in renal disease. Clin Chem Lab Med 1998;36/2:87-92.
27. Van Lente F, Mc Erlean ES, DeLuca SA, Peacock WF, Rao JS, Nissen SE: Ability of troponins to predict adverse outcomes in patients with renal insufficiency and suspected acute coronary syndromes: A case-matched study. J Am Coll Cardiol 1999;33:471-478.
28. Lofberg M, Tahtela R, Harkonen M, Somer H: Myosin heavy-chain fragments and cardiac troponins in the serum in rhabdomyolysis. Diagnostic specificity of new biochemical markers. Arch Neurol 1995;52:1210-1214.
29. Kobayashi S, Tanaka M, Tamura N, Hashimoto H, Hirose S: Serum cardiac troponin T in polymyositis/dermatomyositis. Lancet 1992; 340:726.
30. Siegel AJ, Sholar M, Yang J, Dhanak E, Lewandrowski KB: Elevated serum cardiac markers in asymptomatic marathon runners after competition: Is the myocardium stunned? Cardiology 1997;88:487-491.
31. Rifai N, Douglas PS, O'Toole M, Rimm E, Ginsburg GS: Cardiac troponin T and I, echocardiographic wall motion analyses, and ejection fraction in athletes participating in the Hawaii Ironman Triathlon. Am J Cardiol 1999;87:1085-1089.
32. Cohen LF, Mohaheer AJ, Keffer JH, Jialal I: Troponin I in hypothyroidism. Clin Chem 1996;42:1494-1495.
33. Spies C, Haude V, Fitzner R, Schroder K, Overbeck M, Runkel N, Schaffartzik W: Serum cardiac troponin T as a prognostic marker in early sepsis. Chest 1998;113:1055-1063.
34. Pateron D, Beyne P, Laperche T, Logeard D, Lefilliatre P, Sogni P, Moreau R, Langlet P, Elman A, Bernuau J, Valla D, Erlinger S, Lebrec D: Elevated circulating cardiac troponin I in patients with cirrhosis. Hepatology 1999;29: 640-643.
35. Mahalingam M, Ottlinger ME: A case against the specificity of 'cardiac' troponin T. J Clin Pathol 1996;49:766-767.
36. Missov E, Calzolari C, Pau B: Increased levels of cardiac troponin I in cancer patients. J Am Coll Cardiol 1997;29:321A.
37. Missov E, Calzolari C, Davy JM, Leclercq F, Rossi M, Pau B: Cardiac troponin I in patients with hematologic malignancies. Coron Artery Dis 1997;8:537-541.
38. Choy JB, Ultan RA, Campbell PM, Prosser CI, Armstrong PW: Clinical utility of cardiac troponin I and second generation cardiac troponin T in hemodialysis patients. Circulation 1998; 98:1-424.
39. Wright SA, Sawyer DB, Sacks DB, Chyu S, Goldhaber SZ: Elevation of troponin I levels in patients without evidence of myocardial injury. JAMA 1997;278:2144.
40. Kollef MH, Ladenson JH, Eisenberg PR: Clinically recognized cardiac dysfunction: An independent determinant of mortality among critically ill patients. Is there a role for serial measurements of cardiac troponin I? Chest 1997; 111:1340-1347.
41. Khan IA, Tun A, Wattanasauwan N, Wit MT, Hla TA, Hussain A, Vasavada BC, Sacchi TJ: Elevation of serum cardiac troponin I in noncardiac and cardiac diseases other than acute coronary syndromes. Am J Emerg Med 1999; 17:225-229.
42. Guest TM, Ramanathan AV, Tuteur PG, Schechtman KB, Ladenson JH, Jaffe AS: Myocardial injury in critically ill patients. A frequently unrecognized complication. JAMA 1995;273:1945-1949.
43. Roppolo LP, Fitzgerald R, Dillow J, Ziegler T, Rice M, Maisel A: A comparison of troponin T and troponin I as predictors of cardiac events in patients undergoing chronic dialysis at a Veteran's Hospital: A pilot study. J Am Coll Cardiol 1999;34:448-454.