Heart mitochondrial respiratory chain complexes are functionally unaffected in heavy ethanol drinkers without cardiomyopathy

Alcoholism: Clinical and Experimental Research

Volumn 24, Issue 6, 2000, Pages 859-864

  Miró, Òscar ^a,c   Robert, Jordi ^a   Casademont, Jordi ^a   Alonso, Josep R ^a   Nicolás, Josep M ^a   Fernández Solá, Joaquim ^a   Urbano Márquez, Àlvaro ^a   Hoek, Jan B ^b   Cardellach, Francesc ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c HOSPITAL CLÍNIC   (Spain)

Author keywords

Cardiomyopathy; Ethanol; Mitochondria; Oxidative Damage

Indexed keywords

CITRATE SYNTHASE;

ADULT; AGED; ALCOHOL CONSUMPTION; ALCOHOLIC CARDIOMYOPATHY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HEART DILATATION; HEART MITOCHONDRION; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE INJURY; HUMAN; HUMAN TISSUE; LIPID PEROXIDATION; MALE; MITOCHONDRIAL RESPIRATION; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIRATORY CHAIN;

EID: 0033933837     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2000.tb02066.x     Document Type: Article

References (45)

1. Bartosz M, Kedziora J, Bartosz G (1997) Antioxidant and prooxidant properties of captopril and enalapril. Free Radie Biol Med 23:729-735.
2. Boveris A and Chance B (1973) The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen. Biochem J 134:707-716.
3. Bradford M (1976) A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Buchwald A, Till H, Unterberg C, Oberschmidt R, Figulla HR, Wiegand V (1990) Alterations of the mitochondrial respiratory chain in human dilated cardiomyopathy. Eur Heart J 11:509-516.
5. Cardellach F, Galofré J, Grau JM, Casademont J, Hoek JB, Rubin E, Urbano-Marquez A (1992) Oxidative metabolism in muscle mitochondria from patients with chronic alcoholism. Ann Neurol 31:515-518.
6. Cardellach F, Taraschi TF, Ellingson JS, Stubbs CD, Rubin E, Hoek JB (1991) Maintenance of structural and functional characteristics of skeletal-muscle mitochondria and sarcoplasmic-reticular membranes after chronic ethanol treatment. Biochem J 274:565-573.
7. Chretien D, Gallego J, Barrientos A, Casademont J, Cardellach F, Munnich A, Rotig A, Rustin P (1998) Biochemical parameters for the diagnosis of mitochondrial respiratory chain deficiency in humans, and their lack of age-related changes. Biochem J 329:249-254.
8. Cunningham CC, Kouri DL, Beeker KR, Spach PI (1989) Comparison of effects of long-term ethanol consumption on the heart and liver of the rat. Alcohol Clin Exp Res 13:58-65.
9. Cunningham CC, Spach PI (1994) Alcoholism and myocardial energy metabolism. Alcohol Clin Exp Res 18:132-137.
10. Fernández-Solá J, Estruch R, Grau JM, Paré JC, Rubin E, Urbano-Márquez A (1994) The relation of alcoholic myopathy and cardiomyopathy. Ann Intern Med 120:529-536.
11. Giulivi C, Boveris A, Cardenas E (1995) Hydroxyl radical generation during mitochondrial electron transfer and the formation of 8-hydroxydesoxyguanosine in mitochondrial DNA. Arch Biochem Biophys 316:909-916.
12. Hedley D, Cho S (1992) Flow cytometric measurement of lipid peroxidation in vital cells using parinaric acid. Cytometry 13:686-692.
13. Hoek JB (1994) Mitochondrial energy metabolism in chronic alcoholism. Curr Top Bioenerg 17:197-241.
14. Jarreta D, Orus J, Barrientos A, Miró O, Roig E, Heras M, Moraes CT, Cardellach F, Casademont J (2000) Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy. Cardiovasc Res 45:860-865.
15. Kennedy JM (1998) Mitochondrial gene expression is impaired by ethanol exposure in cultured chick cardiac myocytes. Cardiovasc Res 37:141-150.
16. Kirkova M, Ivancheva E, Russanov E (1995) Lipid peroxidation and antioxidant enzyme activity in aspirin-treated rats. Gen Pharmacol 26: 613-617.
17. Kou SY, Cohen NS (1998) Ethanol feeding produces deficiencies in left ventricle total RNA, total DNA and mitochondrial ribosomal RNA. Int J Biochem Cell Biol 30:475-485.
18. Lange LG, Sobel BE (1983) Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol. J Clin Invest 72: 724-731.
19. Lappena D, de Gioia S, Ciofani G, Bruno C, Porreca E, Pierdomenico SD, Cuccurullo F (1998) Antioxidant properties of ticlopidine on human low density lipoprotein oxidation. FEBS Lett 436:357-360.
20. Li HL, Moreno-Sanchez R, Rottenberg H (1995) Alcohol inhibits the activation of NAD-linked dehydrogenases by calcium in brain and heart mitochondria. Biochim Biophys Acta 1236:306-316.
21. Lorenz R, Janicke-Lorenz J (1984) Ultrastructural studies on experimental alcoholic heart disease in rats. Z Versuchstierk 26:151-156.
22. Marin-Garcia J, Ananthakrishnan R, Goldenthal MJ (1995a) Heart mitochondria response to alcohol is different than brain and liver. Alcohol Clin Exp Res 19:1463-1466.
23. Marin-Garcia J, Goldenthal MJ, Pierpont ME, Ananthakrishnan R (1995b) Impaired mitochondrial function in idiopathic dilated cardiomyopathy: Biochemical and molecular analysis. J Card Fail 1:285-291.
24. Mason RP, Mak IT, Trumbore MW, Mason PE (1999) Antioxidant properties of calcium antagonists related to membrane biophysical interactions. Am J Cardiol 84:16L-22L.
25. Meckel CR, Wilson JE, Sears TD, Rogers JG, Goaley TJ, McManus BM (1989) Myocardial fibrosis in endomyocardial biopsy specimens: Do different bioptomes affect estimation? Am J Cardiac Pathol 2:309-313.
26. Miró O, Alonso JR, Jarreta D, Casademont J, Urbano-Márquez A, Cardellach F (1999b) Smoking disturbs mitochondrial respiratory chain function and enhances lipid peroxidation on human circulating lymphocytes. Carcinogenesis 20:1331-1336.
27. Miró O, Barrientos A, Alonso JR, Casademont J, Jarreta D, Urbano-Márquez A, Cardellach F (1999a) Effects of general anesthetic procedures on mitochondrial function of human skeletal muscle. Eur J Clin Pharmacol 55:35-41.
28. Miró O, Cardellach F, Barrientos A Casademont J, Rötig A, Rustin P (1998) Cytochrome c oxidase assay in minute amount of human skeletal muscle using single wavelength spectrophotometers. J Neurosci Methods 80:107-111.
29. Pachinger OM, Tillmanns H, Mao JC, Fauvel JM, Bing RJ (1973) The effect of prolonged administration of ethanol on cardiac metabolism and performance in the dog. J Clin Invest 52:2690-2696.
30. Patel VB, Why HJ, Richardson PJ, Preedy VR (1997) The effects of alcohol on the heart. Adverse Drug React Toxicol Rev 16:15-43.
31. Preedy VR, Patel VB, Why HJ, Corbett JM, Dunn MJ, Richardon PJ (1996) Alcohol and the heart: Biochemical alterations. Cardiovasc Res 31:139-147.
32. Redetzki JE, Griswold KE, Nopajaroonski C, Redetzki HM (1983) Amelioration of cardiotoxic effects of alcohol by vitamin E. J Toxicol Clin Toxicol 20:319-331.
33. Ribiere C, Hininger I, Saffar-Boccara C, Sabourault D, Nordmann R (1994) Mitochondrial respiratory activity and superoxide radical generation in the liver, brain and heart after chronic ethanol intake. Biochem Pharmacol 47:1827-1833.
34. Rouach H, Clement M, Orfanelli MT, Janvier B, Nordmann J, Nordmann R (1983) Hepatic lipid peroxidation and mitochondrial susceptibility to peroxidative attacks during ethanol inhalation and withdrawal. Biochim Biophys Acta 753:439-444.
35. Rubin E, Beattie DS, Lieber CS (1970) Effects of ethanol on the biogenesis of mitochondrial membranes and associated mitochondrial functions. Lab Invest 23:620-627.
36. Rustin P, Chretien D, Bourgeron T, Gerard B, Rotig A Saudubray JM, Munnich A (1994a) Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chim Acta 228:35-51.
37. Rustin P, Chretien D, Bourgeron T, LeBidois J, Sidi D, Rötig A, Munnich A (1993) Investigation of respiratory chain activity in human heart. Biochem Med Metabol Biol 50:120-126.
38. Rustin P, Lebidois J, Chretien D, Bourgeron T, Piechaud JF, Rötig A, Munnich A, Sidi D (1994b) Endomyocardial biopsies for early detection of mitochondrial disorders in hypertrophic cardiomyopathies. J Pediatr 124:224-228.
39. Schultheiss HP, Spiegel M, Boite HD (1985) The effects of chronic ethanol consumption on oligomycin sensitive ATPase activity in the guinea pig heart. Basic Res Cardiol 80:548-555.
40. Segel LD (1984) Mitochondrial respiration after cardiac perfusion with ethanol or acetaldehyde. Alcohol Clin Exp Res 8:560-564.
41. Segel L, Rendig S, Choquet Y, Chacko K, Amsterdam E, Mason D (1997) Effects of chronic graded ethanol consumption on the metabolism, ultrastructure, and mechanical function of the rat heart. Cardiovasc Res 9:649-663.
42. Siddiq T, Salisbury JR, Richardson PJ, Preedy VR (1993) Synthesis of ventricular mitochondrial proteins in vivo: Effect of acute ethanol toxicity. Alcohol Clin Exp Res 17:894-899.
43. Taraschi TF, Rubin E (1985) Effects of ethanol on the chemical and structural properties of biologic membranes. Lab Invest 52:120-131.
44. Unverferth DV, Lee SW, Wallick ET (1988) Human myocardial adenosine triphosphatase activities in health and heart failure. Am Heart J 115:139-146.
45. Urbano-Márquez A, Estruch R, Navarro-López F, Grau JM, Mont L, Rubin E (1989) The effects of alcoholism on skeletal and cardiac muscle. N Engl J Med 320:409-415.