Importance of holotoxin assembly in Ptl-mediated secretion of pertussis toxin from Bordetella pertussis

Infection and Immunity

Volumn 68, Issue 7, 2000, Pages 4049-4054

  Farizo, Karen M ^a   Huang, Theresa ^a   Burns, Drusilla L ^a  

^a CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PERTUSSIS TOXIN;

ARTICLE; BACTERIAL VIRULENCE; BORDETELLA PERTUSSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; STRUCTURE ANALYSIS; TOXIN STRUCTURE; TOXIN SYNTHESIS;

BASE SEQUENCE; BIOLOGICAL TRANSPORT, ACTIVE; BORDETELLA PERTUSSIS; DNA PRIMERS; GENES, BACTERIAL; PERTUSSIS TOXIN; PLASMIDS; PROTEIN STRUCTURE, QUATERNARY; SEQUENCE DELETION; VIRULENCE; VIRULENCE FACTORS, BORDETELLA;

EID: 0033931948     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.7.4049-4054.2000     Document Type: Article

References (32)

1. Antoine, R., and C. Locht. 1990. Roles of the disulfide bond and the carboxy-terminal region of the S1 subunit in the assembly and biosynthesis of pertussis toxin. Infect. Immun. 58:1518-1526.
2. Barry, E. M., A. A. Weiss, I. E. Ehrmann, M. C. Gray, E. L. Hewlett, and M. S. M. Goodwin. 1991. Bordetella pertussis adenylate cyclase toxin and hemolytic activities require a second gene, cyaC, for activation. J. Bacteriol. 173:720-726.
3. Brickman, E., and J. Beckwith. 1975. Analysis of the regulation of Escherichia coli alkaline phosphatase synthesis using deletions and φ80 transducing phages. J. Mol. Biol. 96:307-316.
4. Bullock, J. O., S. K. Armstrong, J. L. Shear, D. P. Lies, and M. A. McIntosh. 1990. Formation of ion channels by colicin B in planar lipid bilayers. J. Membr. Biol. 114:79-95.
5. Burnette, W. N. 1981. "Western blotting": electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A. Anal. Biochem. 112:195-203.
6. Burns, D. L., S. Z. Hausman, W. Lindner, F. A. Robey, and C. R. Manclark. 1987. Structural characterization of pertussis toxin A subunit. J. Biol. Chem. 262:17677-17682.
7. Christie, P. J. 1997. Agrobacterium tumefaciens T-complex transport apparatus: a paradigm for a new family of multifunctional transporters in eubacteria. J. Bacteriol. 179:3085-3094.
8. Cook, D. M., K. M. Farizo, and D. L. Burns. 1999. Identification and characterization of PtlC, an essential component of the pertussis toxin secretion system. Infect. Immun. 67:754-759.
9. DeFeyter, R., Y. Yang, and D. W. Gabriel. 1993. Gene-for-genes interactions between cotton R genes and Xanthomonas campestris pv. malvacearum avr genes. Mol. Plant-Microbe Interact. 6:225-237.
10. Figurski, D. H., and D. R. Helinski. 1979. Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans. Proc. Natl. Acad. Sci. USA 76:1648-1652.
11. Frank, D. W., and C. D. Parker. 1984. Interaction of monoclonal antibodies with pertussis toxin and its subunits. Infect. Immun. 46:195-201.
12. Gilman, A. G. 1987. G proteins: transducers of receptor generated signals. Annu. Rev. Biochem. 56:615-649.
13. Hausman, S. Z., J. D. Cherry, U. Heininger, C. H. Wirsing von Konig, and D. L. Burns. 1996. Analysis of proteins encoded by the ptx and ptl genes of Bordetella bronchiseptica and Bordetella parapertussis. Infect. Immun. 64: 4020-4026.
14. Johnson, F. D., and D. L. Burns. 1994. Detection and subcellular localization of three Ptl proteins involved in the secretion of pertussis toxin from Bordetella pertussis. J. Bacteriol. 176:5350-5356.
15. Katada, T., M. Tamura, and M. Ui. 1983. The A promoter of islet-activating protein, pertussis toxin, as an active peptide catalyzing ADP-ribosylation of a membrane protein. Arch. Biochem. Biophys. 224:290-298.
16. Katada, T., and M. Ui. 1982. Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein. Proc. Natl. Acad. Sci. USA 79:3129-3133.
17. Keen, N. T., S. Tamaki, D. Kobayashi, and D. Trollinger. 1988. Improved broad-host-range plasmids for DNA cloning in Gram-negative bacteria. Gene 70:191-197.
18. Kenimer, J. G., K. J. Kim, P. G. Probst, C. R. Manclark, D. G. Burstyn, and J. L. Cowell. 1989. Monoclonal antibodies to pertussis toxin: utilization as probes of toxin function. Hybridoma 8:37-51.
19. Kim, K. J., W. N. Burnette, R. D. Sublett, C. R. Manclark, and J. G. Kenimer. 1989. Epitopes on the S1 subunit of pertussis toxin recognized by monoclonal antibodies. Infect. Immun. 57:944-950.
20. Kotob, S. I., and D. L. Burns. 1997. Essential role of the consensus nucleotide-binding site of PtlH in secretion of pertussis toxin from Bordetella pertussis. J. Bacteriol. 179:7577-7580.
21. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (London) 227:680-685.
22. Locht, C., and J. M. Keith. 1986. Pertussis toxin gene: nucleotide sequence and genetic organization. Science 232:1258-1264.
23. Nicosia, A., M. Perugini, C. Franzini, M. C. Casagli, M. G. Borri, G. Antoni, M. Almoni, P. Neri, G. Ratti, and R. Rappuoli. 1986. Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication. Proc. Natl. Acad. Sci. USA 83:4631-4635.
24. Pizza, M., M. Bugnoli, R. Manetti, A. Covacci, and R. Rappuoli. 1990. The subunit S1 is important for pertussis toxin secretion. J. Biol. Chem. 265: 17759-17763.
25. Simon, R., U. Priefer, and A. Puhler. 1983. A broad host range mobilization system for in vivo genetic engineering: transposon mutagenesis in Gram negative bacteria. Bio/Technology 1:784-790.
26. Stein, P. E., A. Boodhoo, G. D. Armstrong, S. A. Cockle, M. H. Klein, and R. J. Read. 1994. The crystal structure of pertussis toxin. Structure 2:45-57.
27. Stibitz, S. 1994. Use of conditionally counterselectable suicide vectors for allelic exchange. Methods Enzymol. 235:458-465.
28. Stibitz, S., and M.-S. Yang. 1991. Subcellular localization and immunochemical detection of proteins encoded by the vir locus of Bordetella pertussis. J. Bacteriol. 173:4288-4296.
29. Tamura, M., K. Nogimori, S. Murai, M. Yajima, K. Ito, T. Katada, M. Ui, and S. Ishii. 1982. Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model. Biochemistry 21:5516-5522.
30. Weiss, A. A., F. D. Johnson, and D. L. Burns. 1993. Molecular characterization of an operon required for pertussis toxin secretion. Proc. Natl. Acad. Sci. USA 90:2970-2974.
31. Weiss, A. A., A. R. Melton, K. E. Walker, C. Andraos-Selim, and J. J. Meidl. 1989. Use of the promoter fusion transposon Tn5 lac to identify mutations in Bordetella pertussis vir-regulated genes. Infect. Immun. 57:2674-2682.
32. Winans, S. C., D. L. Burns, and P. J. Christie. 1996. Adaptation of a conjugal transfer system for the export of pathogenic macromolecules. Trends Microbiol. 4:64-68.