Protein-bound D-amino acids, and to a lesser extent lysinoalanine, decrease true ileal protein digestibility in minipigs as determined with N- labelling

Journal of Nutrition

Volumn 130, Issue 8, 2000, Pages 2026-2031

  De Vrese, Michael ^a   Frik, Regine ^a   Roos, Nils ^a   Hagemeister, Hans ^b  

^a FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

^b LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

Author keywords

15N labeling; D amino acids; Lysinoalanine; Miniature pigs; True protein digestibility

Indexed keywords

ASPARAGINE; ASPARTIC ACID; BETA LACTOGLOBULIN; CASEIN; DEXTRO AMINO ACID; LYSINOALANINE; M PROTEIN; NITROGEN 15; PHENYLALANINE; TYROSINE; VEGETABLE PROTEIN;

ADOLESCENT; ARTICLE; CROSS LINKING; DIGESTION; INTESTINE; ISOTOPE LABELING; MALE; NONHUMAN; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTAKE; SWINE;

SUS SCROFA; TRITICUM AESTIVUM;

EID: 0033931268     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/130.8.2026     Document Type: Article

References (31)

1. Bunjapamai, S., Mahoney, R. R. & Fagerson, I. S. (1932) Determination of D-amino acids in some processed foods and effect of racemization on in vitro digestibility of casein. J. Food Sci. 47: 1229-1234.
2. Chung, S.-Y., Swaisgood, H. E. & Catignani, G. L. (1986) Effects of alkali treatment and heat treatment in the presence of fructose on digestibility of food proteins as determined by an immobilized digestive enzyme assay (IDEA). J. Agric. Food Chem. 34: 579-584.
3. De Groot, A. P. & Slump, P. (1969) Effects of severe alkali treatment of proteins on amino acid composition and nutritive value. J. Nutr. 98: 45-56.
4. de Vrese, M., Middendorf, K. & Hagemeister, H. (1994) Prevention of amino acid racemization during guanidination - a prerequisite for measurement of protein digestibility by homoarginine labeling. Z. Ernährwiss. 33: 310-312.
5. 15N-recovery in pigs. In: VIth International Symposium on Digestive Physiology in Pigs (Souffrant, W.-B. & Hagemeister, H., eds.), pp. 64-66. EAAP Publication no. 80, Dummerstorf, Germany.
6. Erbersdobler, H. F. (1990) Tiermodelle im Protein-und Aminosäurenstoffwechsel. In: Tiermodelle für die menschliche Ernährungsphysiologie (Kirchgeßner, M., ed.), pp. 27-38. Verlag Paul Parey, Hamburg, Germany.
7. FAO/WHO (1990) Protein quality evaluation. Report of a Joint FAO/WHO Expert Consultation. December 1989, Bethesda, MD. Food and Agriculture Organization of the United Nations, Rome, 1990.
8. Frank, H. (1990) Gas chromatography of enantiomers on chiral stationary phase. In: Chirality and Biological Activity (Holmstedt, B., Frank, H. & Testa, B., eds.), pp. 33-55.
9. Friedman, M. (1979) Alkali-induced lysinoalanine formation in structurally different proteins. In: Functionality and Protein Structure (Pour-El, A., ed.), pp. 225-235. ACS Symposium Series 92, American Chemical Society, Washington, DC.
10. Friedman, M. (1991) Formation, nutritional value and safety of D-amino acids. In: Nutritional and Toxicological Consequences of Food Processing (Friedman, M., ed.), pp. 447-481. Plenum Press, New York, NY.
11. Friedman M., Grosjean, O.-K. & Zahnley, J. C. (1985) Carboxypeptidase inhibition by alkali-treated food proteins. J. Agric. Food Chem. 33: 208-213.
12. 15N and homoarginine. In: Protein Metabolism and Nutrition. Vol. 2. Short Communications (Eggum, B. O., Boisen, S., Børsting, C., Danfær, A. & Hvelplund, T., eds.), pp. 36-38. EAAP-publication no. 59, National Institute of Animal Science, Research Center Foulum.
13. Jenkins, W. L, Tovar, L. R., Schwass, D. E., Liardon, R. & Carpenter, K. J. (1984) Nutritional characteristics of alkali-treated zein. J. Agric. Food Chem 32: 1035-1041.
14. Jervis, E. L. & Smyth, D. H. (1959) The effect of concentrations of amino acids on their rate of absorption from the intestine. J. Physiol. 149: 433-441.
15. Liardon, R. & Ledermann, S. (1986) Racemization kinetics of free and protein-bound amino acids under moderate alkaline treatment. J. Agric. Food Chem. 34: 557-565.
16. Lister, N., Sykes A. P., Baily, P. D., Boyd, C.A.R. & Bronk, J. R. (1995) Dipeptide transport and hydrolysis in isolated loops of rat small intestine: effects of stereospecificity. J. Phys. 484: 173-182.
17. Man, E. H. &, Bada, J. F. (1987) Dietary D-amino acids. Annu. Rev. Nutr. 7: 209-225.
18. Maubois, L., Pierre, A., Fauquant, J. & Piot, M. (1987) Industrial fractionation of main whey proteins. Bull. Int. Dairy Fed. 212: 154-159.
19. Moughan, P. J., Cranwell, P. D., Derragh, A. J. & Rowan, A. M. (1994) The domestic pig as a model animal for studying digestion in humans. In: FBN Schriftenreihe JSSNO 1946-1981, vol. 4 (Souffrant, W.B. & Hagemeister, H., eds.), pp. 389-396. Dummerstorf, Germany.
20. Moughan, P. J. & Rowan, A. M. (1989) The pig as a model animal for human nutrition research. Proc. Nutr. Soc. N.Z. 14: 116-123.
21. Pappenheimer, J. R., Karnovsky, M. L. & Maggio, J. E. (1997) Absorption and excretion of undegradable peptides: role of lipid solubility and net charge. J. Pharmacol. Exp. Ther. 280: 292-300.
22. Paquet, A., Thresher, W. C., Swaisgood, H. E. & Catignani, G. L. (1985) Synthesis and digestibility determination of some epimeric tripeptides occurring in dietary proteins. Nutr. Res. 5: 891-901.
23. Possompes, B., Cuq, J. L., Guenoun, D. & Besançon, P. (1983) Use of cysteine as a reducing agent during alkali treatment of proteins. Biochemical and nutritional effects. Food Chem. 11: 15-26.
24. 15N compared with homoarginine suggests a lower prececal digestibility of casein. J. Nutr. 124: 2404-2409.
25. Savoie, L. (1984) Effect of protein treatment on the enzymatic hydrolysis of lysinoalanine and other amino acids. In: Advances in Experimental Medicine and Biology, Vol. 177: Nutritional and Toxicological Aspects of Food Safety (Friedman, M., ed.), pp. 413-422. Plenum Press, New York, NY.
26. Scheffé, H. (1953) A method for judging all contrasts in the analysis of variance. Biometrika 40: 87-104.
27. Schmitz, M., Hagemeister, H. & Erbersdobler, H. F. (1991) Homoarginine labeling is suitable for determination of protein absorption in miniature pigs. J. Nutr. 121: 1575-1580.
28. Schwass, D. E. & Finley, J. W. (1984) Heat and alkaline damage to proteins: racemization and lysinoalanine formation. J. Agric. Food Chem. 32: 1377-1382.
29. Schwass, D. E., Tovar, L. R. & Finley, J. W. (1983) Absorption of altered amino acids from the intestine. In: Xenobiotics in Foods and Feeds (Finley, J. W. & Schwass, D. E., eds.), pp. 187-201. ACS Symposium Series 234, American Chemical Society, Washington, DC.
30. Stevenson, A. E. & De Langen, H. (1960) Measurement of feed intake by grazing cattle and sheep. VII. Modified wet digestion method for determination of chromic oxide in faeces. N.Z. J. Agric. Res. 3: 314-319.
31. Zagon, J., Dehne, L.-L. & Bögl, K.-W. (1994) D-Amino acids in organisms and food. Nutr. Res. 14: 445-463.