Evaluation of the kinetics of β-elimination reactions of selenocysteine se-conjugates in human renal cytosol: Possible implications for the use as kidney selective prodrugs

Journal of Pharmacology and Experimental Therapeutics

Volumn 294, Issue 2, 2000, Pages 762-769

  Rooseboom, Martijn ^a   Vermeulen, Nico P E ^a   Andreadou, Ioanna ^a   Commandeur, Jan N M ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

(2 CHLORO 1,1,2 TRIFLUOROETHYL) LEVO CYSTEINE; ANTINEOPLASTIC AGENT; CYSTEINE CONJUGATE; CYSTEINE CONJUGATE BETA LYASE; PRODRUG; SELENIUM DERIVATIVE; SELENOCYSTEINE; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMOPROPHYLAXIS; CONJUGATE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME SUBSTRATE; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

AGED; ANIMALS; CYTOSOL; HUMANS; KIDNEY; KINETICS; LYASES; MALE; MIDDLE AGED; PRODRUGS; RATS; RATS, WISTAR; SELENOCYSTEINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0033929438     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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