Age-related changes in irradiation-induced apoptosis and expression of p21 and p53 in crypt stem cells of murine intestine

Annals of the New York Academy of Sciences

Volumn 908, Issue , 2000, Pages 315-318

  Martin, Kareen ^a,b   Potten, Christopher S ^b   Kirkwood, Thomas B L ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CHRISTIE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P21; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; CONFERENCE PAPER; CONTROLLED STUDY; GAMMA IRRADIATION; INTESTINE CRYPT; MOUSE; NONHUMAN;

ANIMALIA; MURINAE;

EID: 0033929329     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2000.tb06662.x     Document Type: Conference Paper

References (7)

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2. 2. POTTEN, C.S. et al. 1997. The intestinal epithelial stem cell: the mucosal governor. Int. J. Exp. Pathol. 78: 219-243.
3. 3. CLARKE, A.R. et al. 1997. p53, mutation frequency and apoptosis in the murine small intestine. Oncogene 14: 2015-2018.
4. 4. MERRITT, A.J. et al. 1997. Apoptosis in small intestinal epithelial from p53-null mice: evidence for a delayed, p53-independent G2/M-associated cell death after gamma-irradiation. Oncogene 14: 2759-2766.
5. 5. MARTIN, K. et al. 1998. Age changes in stem cells of murine small intestinal crypts. Exp. Cell. Res. 241: 316-323.
6. 6. ARAI, T. et al. 1996. Comparative alterations in p53 expression and apoptosis in the irradiated rat small and large intestine. Br. J. Cancer 74: 406-412.
7. 7. WILSON, J.W. et al. 1998. Radiation-induced p53 and p21WAF-1/CIP1 expression in the murine intestinal epithelium: apoptosis and cell cycle arrest. Am. J. Pathol. 153: 899-909.