Effect of PCBs on the activation of the transcription factors AP-1 and NF-κB

Central European Journal of Public Health

Volumn 8, Issue SUPPL., 2000, Pages 17-18

  Glauert, H P ^a,b   Tharappel, J C ^a   Lee, E Y ^a   Robertson, L W ^b   Spear, B T ^a  

^a Dept of Nutrition and Food Science ^*

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Carcinogenesis; Liver; PCB; Transcription factors

Indexed keywords

GUANOSINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPID; POLYCHLORINATED BIPHENYL; TRANSCRIPTION FACTOR AP 1;

ANIMAL TISSUE; CARCINOGENESIS; CONFERENCE PAPER; DNA DAMAGE; FEMALE; LIPID PEROXIDATION; LIVER CELL CARCINOMA; NONHUMAN; OXIDATION; RAT;

ANIMALS; FEMALE; NF-KAPPA B; OXIDATIVE STRESS; POLYCHLORINATED BIPHENYLS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTOR AP-1;

EID: 0033928797     PISSN: 12107778     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (12)

1. Silberhorn, E. M., Glauert, H. P., Robertson, L. W.: Carcinogenicity of polyhalogenated biphenyls: PCBs and PBBs. Crit. Rev. Toxicol. 20, 1990, 439-496.
2. Twaroski, T. P., Arif, J. M., Gupta, R. C., Robertson, L. W.: Antioxidant enzyme levels and oxidative damage in rats exposed to selected polychlorinated biphenyls (PCBs) after maximal cytochrome P450 induction Proc. Amer. Assoc. Cancer Res. 40, 1999, 647-648.
3. 2 and antioxidants have opposite effects on the activation of NFkB and AP-1 in intact cells: AP-1 as secondary antioxidant-response factor EMBO J. 12, 1993, 2005-2015.
4. Liu, S. L., Esposti, S. D., Yao, T., Diehl, A. M., Zern, M. A.: Vitamin E therapy of acute CC14-induced hepatic injury in mice is associated with inhibition of nuclear factor kappa B binding. Hepatology 22, 1995, 1474-1481.
5. Amstad, P. A., Krupitza, G., Cerutti, P. A.: Mechanism of c-fos induction by active oxygen Cancer Res 52, 1992, 3952-2960
6. Abate, C., Patel, L., Rauscher, F., Curran, T.: Redox regulation of fos and jun DNA binding activity in vitro Science 248, 1990, 189-194.
7. Li, Y., Leung, L. K., Glauert, H. P., Spear, B. T.: Treatment of rats with the peroxisome proliterator ciprofibrate results in increased liver NF-kappa B activity Carcinogencsis 17, 1996, 2305-2309.
8. Li, Y., Leung, L. K., Spear, B. T., Glauert, H. P.: Activation of hepatic NF-kB by phenobarbital in rats. Biochem Biophys. Res Commun 229, 1996, 982-989.
9. Nilakantan, V., Spear, B. T., Glauert, H. P.: Liver-specific catalase expression in transgenic mice inhibits NF-kB activation and DNA synthesis induced by the peroxisome proliferator ciprofibrate. Carcinogenesis 19, 1998, 631-637.
10. Glauert, H. P., Clark, T. D.: Lack of initiating activity of the peroxisome proliferator ciprofibrate in two-stage hepatocarcinogenesis. Cancer Lett 43, 1989, 95-100.
11. Bondy, S. C., Naderi, S.: Contribution of hepatic cytochrome P450 systems to the generation of reactive oxygen species Biochem Pharmacol 48, 1994, 155-159
12. Tian, Y., Ke, S., Denison, M. S., Rabson, A. B., Gallo, M. A.: Ah receptor and NF-kappa B interactions, a potential mechanism for dioxin toxicity J Biol. Chem 274, 1999, 510-515