Equivalence of single- and multilocus markers: Power to detect linkage with composite markers derived from biallelic loci

American Journal of Human Genetics

Volumn 66, Issue 5, 2000, Pages 1610-1615

  Wilson, Alexander F ^a   Sorant, Alexa J M ^a  

^a NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; COMPUTER SIMULATION; GENE LOCUS; GENETIC ANALYSIS; GENETIC LINKAGE; GENOTYPE; MARKER GENE; MODEL; PRIORITY JOURNAL;

EID: 0033926575     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302889     Document Type: Article

References (17)

1. Amos CI, Elston RC, Wilson AF, Bailey-Wilson JE (1989) A more powerful robust sib-pair test of linkage for quantitative traits. Genet Epidemiol 6:435-449
2. Blackwelder WC, Elston RC (1982) Power and robustness of sib-pair linkage tests and extension to larger sibships. Commun Stat Theor Methods 11:449-484
3. Goldin LR, Chase GA (1997) Improvement of the power to detect complex disease genes by regional inference procedures. Genet Epidemiol 14:785-789
4. Goldin LR, Chase GA, Wilson AF (1999) Regional inference with averaged p values increases the power to detect linkage. Genet Epidemiol 17:157-164
5. Haseman JK, Elston RC (1972) The investigation of linkage between a quantitative trait and a marker locus. Behav Genet 2:3-19
6. Hodge SE, Boehnke M, Spence MA (1999) Loss of information due to ambiguous haplotyping of SNPs. Nat Genet 21:360-361
7. Holmans P, Clayton D (1995) Efficiency of typing unaffected relatives in an affected-sib-pair linkage study with single-locus and multiple tightly linked markers. Am J Hum Genet 57:1221-1232
8. Kruglyak L (1997) The use of a genetic map of biallelic markers in linkage studies. Nat Genet 17:21-24
9. Kruglyak L, Lander E (1995) Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57:439-454
10. Mohr J (1954) A study of linkage in man. Munksgaard, Copenhagen
11. Morton NE (1956) The detection and estimation of linkage between the genes for elliptocytosis and the Rh blood type. Am J Hum Genet 8:80-96
12. Race RR, Sanger R (1975) Blood groups in man. Oxford University Press, Oxford
13. Renwick JH, Lawler SD (1955) Genetical linkage between the ABO and nail-patella loci. Ann Hum Genet 19:312-331
14. S.A.G.E. (1997) Statistical analysis for genetic epidemiology, release 3.1. Computer program package available from the Department of Epidemiology and Biostatistics, Rammelkamp Center for Education and Research, MetroHealth Campus, Case Western Reserve University, Cleveland
15. Wang DG, Fan J-B, Siao C-J, Berno A, Young P, Sapolsky R, Ghandour G, et al (1998) Large-scale identification, mapping and genotyping of single-nucleotide polymorphisms in the human genome. Science 280:1077-1082
16. Wilson AF, Bailey-Wilson JE, Pugh EW, Sorant AJM (1996) The Genometric Analysis Simulation Program (G.A.S.P.): a software tool for testing and investigating methods in statistical genetics. Am J Hum Genet Suppl 59:A193
17. Wilson AF, Elston RC (1993) Statistical validity of the Haseman-Elston sib-pair test in small samples. Genet Epidemiol 10:593-598