Combination therapy with interferon-α plus N-acetyl cysteine for chronic hepatitis C: A placebo controlled double-blind multicentre study

Journal of Medical Virology

Volumn 61, Issue 4, 2000, Pages 439-442

  Grant, P R ^a   Black, A ^b   Garcia, N ^c   Prieto, J ^c   Garson, J A ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Clinical trial; Hepatitis C virus; Interferon; N acetyl cysteine; Treatment

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALPHAN1 INTERFERON; RIBAVIRIN; VIRUS RNA;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; GENOTYPE; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; LIVER FUNCTION TEST; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PATIENT MONITORING; RANDOMIZED CONTROLLED TRIAL; RNA ANALYSIS; TREATMENT FAILURE; VIREMIA;

ACETYLCYSTEINE; ADULT; ALANINE TRANSAMINASE; ANTIVIRAL AGENTS; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; HEPACIVIRUS; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; ITALY; LIVER; PILOT PROJECTS; RNA, VIRAL; SPAIN; VIREMIA;

EID: 0033924086     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/1096-9071(200008)61:4<439::AID-JMV5>3.0.CO;2-L     Document Type: Article

References (17)

1. Beloqui O, Prieto J, Suarez M, Gil B, Qian CH, Garcia N, Civeira MP. 1993. N-acetyl cysteine enhances the response to interferon-alpha in chronic hepatitis C: a pilot study. J Interferon Res 13:279-282.
2. Bernhard M-C, Junker E, Hettinger A, Lauterburg BH. 1998. Time course of total cysteine, glutathione and homocysteine in plasma of patients with chronic hepatitis C treated with interferon-α with and without supplementation with N-acetylcysteine. J Hepatol 28: 751-755.
3. Brillanti S, Garson J, Foli M, Whitby K, Deaville R, Masci C, Miglioli M, Luigi Barbara L. 1994. A pilot study of combination therapy with ribavirin plus interferon alfa for interferon alfa-resistant chronic hepatitis C. Gastroenterology 107:812-817.
4. Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
5. Cimino L, Belisario MA, Intrieri M, D'Ascoli B, Sacchetti L, Salvatore F, Budillon G. 1998. Effect of N-acetyl-cysteine on lymphomonocyte glutathione and response to interferon treatment in C-virus chronic hepatitis. Ital J Gastroenterol Hepatol 30:189-193.
6. Davis GL, Balart LA, Schiff ER, Lindsay K, Bodenheimer HC Jr, Perrillo RP, Carey W, Jacobson IM, Payne J, Dienstag JL, Van Thiel DH, Tamburrow C, Lefkowitch J, Albrecht J, Meschievitz C, Ortegeo T, Gibas A, Hepatitis Interventional Therapy Group. 1989. Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomised, controlled trial. N Engl J Med 321:1501-1506.
7. Di-Bisceglie AM. 1998. Hepatitis C. Lancet 351:351-355.
8. Garson JA, Brillanti S, Ring C, Perini P, Miglioli M, Barbara L. 1992. Hepatitis C viraemia rebound after "successful" interferon therapy in patients with chronic non-A, non-B hepatitis. J Med Virol 37: 210-214.
9. Garson JA, Brillanti S, Whitby K, Foli M, Deaville R, Masci C, Miglioli M, Barbara L. 1995. Analysis of clinical and virological factors associated with response to alpha interferon therapy in chronic hepatitis C. J Med Virol 45:348-353.
10. Kalebic T, Kinter A, Poli G, Anderson ME, Meister A, Fauci AS. 1991. Suppression of human immunodeficiency virus expression in chronically infected monocytic cells by glutathione, glutathione ester, and N-acetylcysteine. Proc Natl Acad Sci USA 88:986-990.
11. Knodell RG, Ishak KG, Black WC, Chen TS, Craig R, Kaplowitz N, Kiernan TW, Wollman J. 1981. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1:431-435.
12. Liang TJ. 1998. Combination therapy for hepatitis C infection. N Engl J Med 339:1549-1550.
13. Staal FJ, Ela SW, Roederer M, Anderson MT, Herzenberg LA, Herzenberg LA. 1992. Glutathione deficiency and human immunodeficiency virus infection. Lancet 339:909-912.
14. Stuyver L, Rossau R, Wyseur A, Duhamel M, Vanderborght B, Van-Heuverswyn H, Maertens G. 1993. Typing of hepatitis C virus isolates and characterisation of new subtypes using a line probe assay. J Gen Virol 74:1093-1102.
15. Suarez M. 1993. Glutathione depletion in chronic hepatitis C. Int Hepatol Commun 1:215-221.
16. Weiss L, Hildt E, Hofschneider PH. 1996. Anti-hepatitis B virus activity of N-acetyl-L-cysteine (NAC) new aspects of a well-established drug. Antiviral Res 32:43-53.
17. Whitby K, Garson JA. 1995. Optimisation and evaluation of a quantitative chemiluminescent polymerase chain reaction assay for hepatitis C virus RNA. J Virol Methods 51:75-88.