Nalmefene to prevent epidural narcotic side effects in pediatric patients: A pharmacokinetic and safety study

Pharmacotherapy

Volumn 20, Issue 7 I, 2000, Pages 745-749

  Rosen, David A ^a   Morris, John L ^a   Rosen, Kathleen R ^a   Nelson, Elizabeth R ^a   Steelman, Robert J ^a   Gustafson, Robert A ^a   Wilhelm, Jeffrey A ^a   Chang, Cheng T ^a   Thackara, Jeffrey W ^a   Frye, Reginald F ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

NALMEFENE;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE CALCULATION; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG SAFETY; EPIDURAL ANESTHESIA; FEMALE; HUMAN; MALE; NAUSEA; PAIN; PEDIATRIC ANESTHESIA; PRESCHOOL CHILD; SCHOOL CHILD; URINE RETENTION; VOMITING;

EID: 0033922920     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.20.9.745.35207     Document Type: Article

References (10)

1. Wang JJ, Ho ST, Tzeng JI. Comparison of intravenous nalbuphine infusion versus naloxone in the prevention of epidural morphine-related side effects. Reg Anesth Pain Med 1948;23:479-84.
2. Gan TJ, Ginsberg B, Glass PS, et al. Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. Anesthesiology 1997;87:1075-81.
3. Choi JH, Lee J, Choi JH, et al. Epidural naloxone reduces pruritus and nausea without affecting analgesia hy epidural morphine in bupivacaine. Can J Anaesth 2000;47:33-7.
4. Ko MC, Naughton NN. An experimental itch model in monkeys: characterization of intrathecal morphine-induced scratching and antinociception. Anesthesiology 2000;92: 795-805.
5. Frye RF, Matzke GR, Schade R, et al. Effects of liver disease on the disposition of the opioid antagonist nalmefene. Clin Pharmacol Ther 1997;61:15-23.
6. Beyer JE, Denyes MJ, Villarruel AM. The creation, validation and continuing development of the Oucher: a measure of pain intensity in children. J Pediatr Nurs 1992;7:335-46.
7. Gillespie WR, Khoo KC. Population pharmacokinetics in pediatric patients using Bayesian approaches with informative prior distributions based on adults [abstr]. Clin Pharmacol Ther 1999;65:140.
8. D'Argenio DZ, Schumitsky A. ADAPT II user's guide (release 4). Biomedical simulations resource. Los Angeles: University of Southern California, March 1997.
9. Frye RF, Matzke GR, Jallad NS, et al. The effect of age on the pharmacokinetics of the opioid antagonist nalmefene. Br J Clin Pharmacol 1996;42:301-6.
10. Matzke GR, Frye RF, Alexander AC, et al. The effect of renal insufficiency and hemodialysis on the pharmacokinetics of nalmefene. J Clin Pharmacol 1996;36:144-51.