A meta-analysis of thromboembolic prophylaxis following elective total hip arthroplasty

Journal of Bone and Joint Surgery

Volumn 82, Issue 7, 2000, Pages 929-938

  Freedman, Kevin B ^a   Brookenthal, Keith R ^b   Fitzgerald, Robert H ^c   Williams, Sankey ^d   Lonner, Jess H ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Department of Orthopaedic Surgery ^*  (United States)

^c Div of General Internal Medicine   (United States)

^d Center for Clinical Epidemiology and Biostatistics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; WARFARIN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEEP VEIN THROMBOSIS; DRUG EFFICACY; DRUG SAFETY; ELECTIVE SURGERY; FEMALE; HUMAN; LUNG EMBOLISM; MALE; META ANALYSIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK BENEFIT ANALYSIS; THROMBOEMBOLISM; TOTAL HIP PROSTHESIS;

EID: 0033922465     PISSN: 00219355     EISSN: None     Source Type: Journal    
DOI: 10.2106/00004623-200007000-00004     Document Type: Article

References (62)

1. Anderson, D. R.; O'Bricn, B. J.; Levine, M. N.; Roberts, R.; Wells, P. S.; and Hirsh, J.: Efficacy and cost of low-molecular-weight heparin compared with standard heparin for the prevention of deep vein thrombosis after total hip arthroplasty. Ann. Intern. Med., 119:1105-1112,1993.
2. Bailey, J. P.; Kruger, M. P.; Solano, F. X.; Zajko, A. B.; and Rubash, II. E.: Prospective randomized trial of sequential compression devices vs low-dose warfarin for deep venous thrombosis prophylaxis in total hip arthroplasty. / Arthroplasty, 6 (Supplement): S29-S35,1991.
3. Bcisaw, N. E.; Comerola, A. J.; Groth, H. E.; Merli, G. J.; Weitz, II. H.; Zinimerman, R. C.; Discrio, F. J.; and Sasahara, A. A.: Dihydroergotamine/heparin in the prevention of deep-vein thrombosis after total hip replacement. A controlled, prospective, randomized multicenter trial. J. Bone and Joint Surg., 70-A: 2-10, Jan. 1988.
4. Clagctt, G. P.; anderson, F. A., Jr.; Heit, J,; Levine, M. N.; and Wheeler, H. B.: Prevention of venous thromboembolism. Chest, 108 (Supplement 4): 312S-334S, 1995.
5. Colwell, C. W., Jr.; Spiro, T. E.; Trowbridge, A. A.; Morris, B. A.; Kwaan, H. C.; Blaha, J. D.; Comerota, A. J.; and Skoutakis, V. A. for the Enoxaparin Clinical Trial Group: Use of cnoxaparin, a low-molecular-weight heparin, and unfractionated heparin for the prevention of deep venous thrombosis after elective hip replacement. A clinical trial comparing efficacy and safety. J. Bone and Joint Surg., 76-A: 3-14, Jan. 1994.
6. Colwell, C. W., Jr., and Spiro, T. E.: Efficacy and safety of enoxaparin to prevent deep vein thrombosis after hip arthroplasty. Clin. Orthop., 319:215-222,1995.
7. Colwell, C. W., Jr.; Spiro, T. E.; Trowbridge, A. A.; Stephens, J. W.; Gardiner, G. A., Jr.; and Ritter, M. A. for the Enoxaparin Clinical Trial Group: Efficacy and safety of enoxaparin versus unfractionated heparin for prevention of deep venous thrombosis after elective knee arthroplasty. Clin. Orthop., 321:19-27,1995.
8. Coventry, M. B.; Nolan, D. R.; and Beckenbaugh, R. D.: "Delayed" prophylactic anticoagulation: a study of results and complications in 2,012 total hip arthroplasties. J. Bone and Joint Surg., 55-A: 1487-1492, Oct. 1973.
9. Danish Enoxaparin Study Group: Low-molecular-weight heparin (enoxaparin) vs dextran 70: the prevention of post-operative deep vein thrombosis after total hip replacement. Arch. Intern. Med., 151:1621-1624,1991.
10. Dechavanne, M.; Ville, D.; Berruyer, M.; Trepo, F.; Dalery, F.; Clermont, N.; Lerat, J. L.; Moyen, B.; Fischer, L. P.; Kher, A.; and Barbier, P.: Randomized trial of a low-molecular-weight heparin (Kabi 2165) versus adjusted-dose subcutaneous standard heparin in the prophylaxis of deep-vein thrombosis after elective hip surgery. Haemostasis, 19:5-12,1989.
11. DerSimonian, R., and Laird, N.: Meta-analysis in clinical trials. Controlled Clin. Trials, 7:177-188,1986.
12. DerSimonian, R., and Levine, R. J.: Resolving discrepancies between a meta-analysis and a subsequent large controlled trial. J. Am. Med. Assn., 282:664-670,1999.
13. Diggle, P. J.; Liang, K.-Y.; and Zeger, S. L.: Analysis of Longitudinal Data. New York, Oxford University Press, 1995.
14. Eriksson, B. I.; Zachrisson, B. E.; Teger-Nilsson, A. C.; and Risberg, B.: Thrombosis prophylaxis with low molecular weight heparin in total hip replacement. British J. Surg., 75:1053-1057,1988.
15. Eriksson, B. L; Kalebo, P.; Anthymyr, B. A.; Wadenvik, II.; Tengborn, L.; and Risberg, B.: Prevention of deep-vein thrombosis and pulmonary embolism after total hip replacement. Comparison of low-molecular-weight heparin and unfractionated heparin. J. Bone and Joint Surg., 73-A: 484-493, April 1991.
16. Eriksson, B. L; Ekman, S.; Lindbratt, S.; Baur, M.; Bach, D.; Torholm, C.; Kalebo, P.; and Close, P.: Prevention of thromboembolism with use of recombinant hirudin. Results of a double-blind, multicenter trial comparing the efficacy of desirudin (Revasc) with that of unfractionated heparin in patients having a total hip replacement. J. Bone and Joint Surg., 79-A: 326-333, March 1997.
17. Feller, J. A.; Parkin, J. D.; Phillips, G. W.; Hannon, P. J.; Hcnnessj', O.; and Huggins, R. M.: Prophylaxis against venous thrombosis after total hip arthroplasty. Australian and New Zealand}. Surg., 62: 606-610,1992.
18. Fender, D.; Harper, W. M.; Thompson, J. R.; and Gregg, P. J.: Mortality and fatal pulmonary embolism after primary total hip replacement. Results from a regional hip register. J. Bone and Joint Surg., 79-B(6): 896-899,1997.
19. Fordyce, M. J. F., and Ling, R. S. M.: A venous foot pump reduces thrombosis after total hip replacement. / Bone and Joint Surg., 74-B(l): 45-49,1992.
20. Francis, C. W.; Marder, V. J.; Evarts, C. McC; and Yaukoolbodi, S.: Two-step warfarin therapy. Prevention of postoperative venous thrombosis without excessive bleeding. J. Am. Med. Assn., 249:374-378,1983.
21. Francis, C. W.; Pcllegrini, V. D., Jr.; Marder, V. J.; Totterman, S.; Harris, C. M.; Gabriel, K. R.; Azodo, M. V.; and Leiberl, K. M.: Comparison of warfarin and external pneumatic compression in prevention of venous thrombosis after total hip replacement. J. Am. Med. Assn., 267:2911-2915,1992.
22. Francis, C. W.; Pcllegrini, V. D., Jr.; Totfernian, S.; Boyd, A. D., Jr.; Marder, V. J.; Lieber!, K. M.; Stulberg, B. N.; Ayers, D. C.; Rosenberg, A.; Kessler, C.; and Johanson, N. A.: Prevention of deep-vein thrombosis after total hip arthroplasty. Comparison of warfarin and dalteparin. J Bone and Joint Surg., 79-A: 1365-1372, Sept. 1997.
23. Freick, H., and Haas, S.: Prevention of deep vein thrombosis by low-molecular-weight heparin and dihydroergotamine in patients undergoing total hip replacement. Thromb. Res., 63:133-143,1991.
24. Gallus, A. S.; Cade, J. F.; Mills, K. W.; and Murphy, W.: Apparent lack of synergism between heparin and dihydroergotamine in prevention of deep vein thrombosis after elective hip replacement: a randomized double-blind trial reported in conjunction with an overview of previous results. Thromb. and Haemost., 68:238-244,1992.
25. German Hip Arthroplasty Trial (GHAT) Group: Prevention of deep vein thrombosis with low molecular-weight heparin in patients undergoing total hip replacement. A randomized trial. Arch. Orthop. and Trauma Surg., Ill: 110-120,1992.
26. Hamulyak, K.; Lcnsing, A. W.; van der Meer, J.; Smid, W. M.; van Ooy, A.; and Hock, J. A.: Subcutaneous low-molecular weight heparin or oral anticoagulants for the prevention of deep-vein thrombosis in elective hip and knee replacement? Fraxiparine Oral Anticoagulant Study Group. Thromb. and Haemost., 74:1428-1431,1995.
27. Harris, W. H.; Salzman, E. VV.; Athanasoulis, C.; Waltman, A. C.; Baum, S.; and DeSanctis, R. W.: Comparison of warfarin, low-molecularweight dextran, aspirin, and subcutaneous heparin in prevention of venous thromboembolism following total hip replacement. / Bone and Joint Surg., 56-A: 1552-1562, Dec. 1974.
28. Harris, W. II.; Salzman, E. W.; Athanasoulis, C. A.; Waltman, A. C.; and DeSanctis, R. W.: Aspirin prophylaxis of venous thromboembolism after total hip replacement. New England J. Med., 297:1246-1249,1977.
29. Harris, W. H.; Athanasoulis, C. A.; Waltman, A. C.; and Salzman, E. W.: High and low-dose aspirin prophylaxis against venous thromboembolic disease in total hip replacement. J. Bone and Joint Surg., 64-A: 63-66, Jan. 1982.
30. Harris, W. H.; Athanasoulis, C. A.; Waltman, A. C.; and Salzman, E. W.: Prophylaxis of deep-vein thrombosis after total hip replacement. Dextran and external pneumatic compression compared with 1.2 or 0.3 gram of aspirin daily. J. Bone and Joint Surg., 67-A: 57-62, Jan. 1985.
31. Hock, J. A.; Nurmohamed, M. T.; Hamclynck, K. J.; Marti, R. K.; Knipschccr, H. C.; ten Cate, H.; Buller, H. R.; Magnani, H. N.; and ten Cafe, J. W.: Prevention of deep vein thrombosis following total hip replacement by low molecular weight heparinoid. Thromb. and Haemost., 67:28-32,1992.
32. Hui, A. C. W.; Hcras-Palou, C.; Dunn, I.; Triffitt, P. D.; Crozier, A.; Imeson, J.; and Gregg, P. J.: Graded compression stockings for prevention of deep-vein thrombosis after hip and knee replacement. J. Bone and Joint Surg., 78-B(4): 550-554,1996.
33. Hull, R. D.; Raskob, G. E.; Gent, M.; McLoughlin, D.; Julian, D.; Smith, F. C.; Dale, N. I.; Reed-Davis, R.; Lofthouse, R. N.; and Anderson, C.: Effectiveness of intermittent pneumatic leg compression for preventing deep vein thrombosis after total hip replacement. J. Am. Med. Assn., 263:2313-2317,1990.
34. Hull, R.; Raskob, G.; Pineo, G.; Rosenbloom, D.; Evans, W.; Mallory, T.; Anquist, K.; Smith, E; Hughes, C.; Green, D.; Elliott, G.; Panju, A.; and Brant, R.: A comparison of subcutaneous low-molecular-weight heparin with warfarin sodium for prophylaxis against deep-vein thrombosis after hip or knee implantation. New England J. Med., 329:1370-1376,1993.
35. Huo, M. H.; Salvati, E. A.; Sharrock, N. E.; Bricn, W. W.; Sculco, T. P.; Pellicci, P. M.; Minco, R.; and Go, G.: Intraoperative heparin thromboembolic prophylaxis in primary total hip arthroplasty. A prospective, randomized, controlled, clinical trial. Clin. Orthop., 274: 3546,1992.
36. Imperiale, T. F., and Speroff, T.: A meta-analysis of methods to prevent venous thromboembolism following total hip replacement. J. Am. Med. Assn., 271:1780-1785,1994.
37. Kaempffc, F. A.; Lifeso, R. M.; and Mcinking, C.: Intermittent pneumatic compression versus Coumadin. Prevention of deep vein thrombosis in lower-extremity total joint arthroplasty. Clin. Orthop., 269:89-97,1991.
38. Kalodiki, E. P.; Hoppensteadt, D. A.; Nicolaides, A. N.; Farced, J.; Gill, K.; Rcgan, F.; al-Kutoubi, A.; Cunningham, D. A.; Birch, R.; Harris, N.; Hunt, D.; Johnson, J.; and Marx, C.: Deep venous thrombosis prophylaxis with low molecular weight heparin and elastic compression in patients having total hip replacement. A randomised controlled trial. Internat. Angiol., 15:162-168,1996.
39. Lassen, M. R.; Borris, L. C.; Christiansen, H. M.; Boll, K. L.; Eiskjaer, S. P.; Niclsen, B. W.; Schott, P.; Olscn, A. D.; Rodenberg, J. C; and Lucht, U.: Prevention of thromboembolism in 190 hip arthroplasties. Comparison of LMW heparin and placebo. Acta Orthop. Scandinavica, 62:33-38,1991.
40. Lerine, M. N.; Hirsh, J.; Gent, M.; Turpic, A. G.; Leclerc, J.; Powers, P. J.; Jay, R. M.; and Neemeh, J.: Prevention of deep vein thrombosis after elective hip surgery. A randomized trial comparing low molecular weight heparin with standard unfractionated heparin. Ann. Intern. Med., 114:545-551,1991.
41. Leyvraz, P. F.; Richard, J.; Bachmann, F.; Van Meile, G.; Treyvaud, J. M.; Livio, J. J.; and Candardjis, G.: Adjusted versus fixed-dose subcutaneous heparin in the prevention of deep-vein thrombosis after total hip replacement. New England J. Med., 309: 954-958,1983.
42. Leyvraz, P.; Bachmann, F.; Bohnet, J.; Brcyer, H. G.; Estoppcy, D.; Haas, S.; Hochreiter, J.; Jakubek, H.; Mair, J.; Sorensen, R.; and Stiekcma, J.: Thromboembolic prophylaxis in total hip replacement: a comparison between the low molecular weight heparinoid Lomoparan and heparin dihydroergotamine. British J. Surg., 79: 911-914,1992.
43. Lieberman, J. R.; Huo, M. M.; Hanway, J.; Salvati, E. A.; Sculco, T. P.; and Sharrock, N. E.: The prevalence of deep venous thrombosis after total hip arthroplasty with hypotensive epidural anesthesia. / Bone and Joint Surg., 76-A: 341-348, March 1994.
44. Lotke, P. A.; Palevsky, H.; Keenan, A. M.; Meranze, S.; Stcinberg, M. E.; Ecker, M. L.; and Kcllcy, M. A.: Aspirin and warfarin for thromboembolic disease after total joint arthroplasty. Clin. Orthop., 324:251-258,1996.
45. Menzin, J.; Colditz, G. A.; Regan, M. M.; Richncr, R. E.; and Oster, G.: Cost-effectiveness of enoxaparin vs low-dose warfarin in the prevention of deep-vein thrombosis after total hip replacement surgery. Arch. Intern. Med., 155:757-764,1995.
46. Mohr, D. N.; Silvcrstcin, M. D.; Murtaugh, P. A.; and Harrison, J. M.: Prophylactic agents for venous thrombosis in elective hip surgery. Meta-analysis of studies using venographic assessment. Arch. Intern. Med., 153:2221-2228,1993.
47. O'Brien, B. J.; andcrson, D. R.; and Coerce, R.: Cost-effectiveness of enoxaparin versus warfarin prophylaxis against deep-vein thrombosis after total hip replacement. CMAJ: Canadian Med. Assn. J., 150:1083-1090,1994.
48. Oster, G.; Tuden, R. L.; and Colditz, G. A.: A cost-effectiveness analysis of prophylaxis against deep-vein thrombosis in major orthopedic surgery. / Am. Med. Assn., 257:203-208,19S7.
49. Paiement, G.; Wessingcr, S. J.; Waltman, A. C.; and-Harris, W. H.: Low-dose warfarin versus external pneumatic compression for prophylaxis against venous thromboembolism following total hip replacement. J. Arthroplasty, 2:23-26,1987.
50. Paiement, G. D.; Wessinger, S. J.; and Harris, W. H.: Cost-effectiveness of prophylaxis in total hip replacement. Am. J. Siirg., 161: 519-524,1991.
51. Parker-Williams, J., and Vickers, R.: Major orthopaedic surgery on the leg and thromboembolism. BMJ: British Med. J., 303:531-532,1991.
52. Planes, A.; Vochclle, N.; Mazas, F.; Mansat, C.; Zucman, J.; Landais, A.; Pascariello, J. C.; Weill, D.; and Bute), J.: Prevention of postoperative venous thrombosis: a randomized trial comparing unfractionated heparin with low molecular weight heparin in patients undergoing total hip replacement. Thromb. and Haemost., 60:407-410,1988.
53. Planes, A.: Comparison of antithrombotic efficacy and haemorrhagic side-effects of Clivarin versus enoxaparin in patients undergoing total hip replacement surgery. Blood Coagulat, and Fibrinol, 4 (Supplement 1): S33-S35,1993.
54. RD Heparin Arthroplasty Group: RD heparin compared with warfarin for prevention of venous thromboembolic disease following total hip or knee arthroplasty. J. Bone and Joint Surg., 76-A: 1174-1185, Aug. 1994.
55. Rogers, P. H.; Walsh, P. N.; Marder, V. J.; Bosak, G. C.; Lachman, J. W.; Ritchie, W. G. M.; Oppenheimer, L.; and Sherry, S.: Controlled trial of low-dose heparin and sulfinpyrazone to prevent venous thromboembolism after operation on the hip. J. Bone and Joint Surg., 60-A: 758762, Sept. 1978.
56. Santori, F. S.; Vitullo, A.; Stopponi, M.; Santori, N.; and Ghera, S.: Prophylaxis against deep-vein thrombosis in total hip replacement. Comparison of heparin and foot impulse pump. J. Bone and Joint Surg., 76-B(4): 579-583,1994.
57. Sarasin, F. P., and Bounamcaux, H.: Antithrombotic strategy after total hip replacement. A cost-effectiveness analysis comparing prolonged oral anticoagulants with screening for deep vein thrombosis. Arch. Intern. Med., 156:1661-1668,1996.
58. Sautlcr, R. D.; Koch, E. L.; Myers, W. O.; Ray, J. R., Ill; Mazza, J. J.; Larson, D. E.; Chen, H. M.; Milbauer, J. P.; Treuhaft, P. S.; Plotka, E. D.; Wendel, F. J.; Nyez, G.; and Pierce, W. E.: Aspirin-sulfinpyrazone in prophylaxis of deep venous thrombosis in total hip replacement. J. Am. Med. Assn., 250:2649-2654,1983.
59. Sharrock, N. E.; Brien, W. W.; Salvati, E. A.; Mineo, R.; Garvin, K.; and Sculco, T. P.: The effect of intravenous fixed-dose heparin during total hip arthroplasty on the incidence of deep-vein thrombosis. A randomized, double-blind trial in patients operated on with epidural anesthesia and controlled hypotension. J. Bone and Joint Surg., 72-A: 1456-1461, Dec. 1990.
60. Turpie, A. G.; Levine, M. N.; Hirsh, J.; Carter, C. J.; Jay, R. M.; Powers, P. J.; andrew, M.; Hull, R. D.; and Gent, M.: A randomized controlled trial of a low-molecular-weight heparin (enoxaparin) to prevent deep-vein thrombosis in patients undergoing elective hip surgery. New England J. Med., 315:925-929,1986.
61. Warwick, D.; Bannister, G. C.; Glew, D.; Mitchelmorc, A.; Thornton, M.; Peters, T. J.; and Brookes, S.: Perioperative low-molecular-weight heparin. Is it effective and safe?J. Bone and Joint Surg., 77-B(5): 715-719,1995.
62. Zinilich, R. H.; Fulbright, M.; and Fricdman, R. J.: Current status of anticoagulation therapy after total hip and total knee arthroplasty. J. Am. Acad. Orthop. Surgeons, 4:54-62,1996.