Mongolian gerbil (Meriones unguiculatus) as a model of cerebral infarction for testing new therapeutic agents

Methods and Findings in Experimental and Clinical Pharmacology

Volumn 22, Issue 4, 2000, Pages 203-210

  Somova, L I ^a   Gregory, M A ^a   Nxumalo, E N ^a  

^a UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Cerebral infarction; Electron microscopy; Mongolian gerbil

Indexed keywords

ALLOPURINOL; CATALASE; CREATINE KINASE; DEFEROXAMINE; MANNITOL; OXIPURINOL; POTASSIUM; SUPEROXIDE DISMUTASE; TRYPAN BLUE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN INFARCTION; CONTROLLED STUDY; DRUG SCREENING; ELECTRON MICROSCOPY; ENZYME INDUCTION; FEMALE; GERBIL; MALE; NONHUMAN; POTASSIUM CELL LEVEL; REPERFUSION INJURY; STROKE; SYMPTOMATOLOGY;

EID: 0033921714     PISSN: 03790355     EISSN: None     Source Type: Journal    
DOI: 10.1358/mf.2000.22.4.584452     Document Type: Article

References (19)

1. Murray, C.J., Lopez, A.D. Global mortality, disability and contribution of risk factors: Global burden of disease study. Lancet 1997, 349: 1436-42.
2. Levin, S., Sohn, D. Cerebral ischaemia in infant and adult gerbils. Arch Path 1969, 87: 360-86.
3. Kahn, K. The natural course of experimental cerebral infarction in the gerbil. Neurology 1972, 22: 510-5.
4. Plum, F., Posner, J.B., Alvord, E.C. Edema and necrosis in experimental cerebral infarction. Arch Neurol 1963, 9: 13-20.
5. Mizuki, T., Kobayashi, H., Ueno, S. et al. Differential changes in alpha-and beta-adrenoreceptors in the cerebral cortex and hippocampus of the Mongolian gerbil after unilateral brain ischemia. Stroke 1995, 26: 2333-7.
6. Stummer, W., Baethman, A., Murr, R. et al. Cerebral protection against ischemia by locomotor activity in gerbils. Underlying mechanisms. Stroke 1995, 26: 1423-9.
7. Zhang, J.R., Andrus, P.K., Hall, E.D. Age-related regional changes in hydroxyl radical stress and antioxidants in gerbil brain. J Neurochem 1993, 61: 1640-7.
8. Harrison, J.G., Sedal, L., Arnold, J., Ross Russel, R.W. No-reflow phenomenon in the cerebral circulation of the gerbil. J Neurol Neurosurg Psychiatr 1975, 38: 1190-3.
9. Payan, H.M., Conard, J.R. Carotid ligation in gerbils. Influence of age, sex and gonads. Lancet 1978, ii: 616-7.
10. Bakay, L. Changes in barrier effect in pathological states. Prog Brain Res 1963, 29: 315-41.
11. Karnovsky, M.J. A formaldehyde glutaraldehyde fixative of high osmolarity for use in electron microscopy. J Cell Biol 1965, 16: 31-4.
12. Spurr, A.R. A low-viscosity epoxy resin embedding medium for electron microscopy. J Ultrastruct Res 1969, 26: 31-5.
13. Reynold, E.S. The use of lead citrate at high pH as an electron opaque stain in electron microscopy. J Cell Biol 1963, 17: 208-10.
14. nd Ed. 1986.
15. Wexler, B.C. Pathophysiological responses to acute cerebral ischemia in the gerbil. Stroke 1972, 3: 71-8.
16. McCord, J.M. Oxygen derived free radicals in postischaemic tissue injury. J Med 1985, 312: 159-63.
17. Korthuis, R.J., Granger, D.N. Reperfusion injury. In: Taylor, A.E., Malon, S., Ward, P.A. (Eds.). Physiology of Oxygen Radicals. Williams and Wilkins: Baltimore, 217-49.
18. Buckley, G.B. Free radical mediated reperfusion injury: A selective review. Br J Cancer 1987, 55: S35-S42.
19. Ratych, R.E., Chuknyiska, R.S., Bulky, G.B. The primary localization of free radicals after anoxia and reoxygenation in isolated endothelial cells. Surgery 1986, 102: 122-31.