Elevation of soluble thrombomodulin antigen levels in the serum and urine of streptozotocin-induced diabetes model rats

Thrombosis Research

Volumn 99, Issue 1, 2000, Pages 83-91

  Nakano, Masahiko ^a   Furutani, Masayuki ^a   Shinno, Hiroyuki ^a   Ikeda, Tomohiro ^b   Oida, Koji ^c   Ishii, Hidemi ^d  

^a MITSUBISHI GAS CHEMICAL COMPANY INC   (Japan)

^b OSAKA CITY GENERAL HOSPITAL   (Japan)

^c UNIVERSITY OF FUKUI   (Japan)

^d SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Diabetes mellitus; EIA; Rat; Streptozotocin; Thrombomodulin

Indexed keywords

ANTIGEN; THROMBIN; THROMBOMODULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM INJURY; ENZYME IMMUNOASSAY; LEUKOCYTE ADHERENCE; NONHUMAN; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES; TISSUE LEVEL; WESTERN BLOTTING;

ANIMALS; ANTIGENS; BLOTTING, WESTERN; CELL ADHESION; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMMUNOGLOBULIN G; MALE; MICROSCOPY, ELECTRON, SCANNING; PLATELET ACTIVATION; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; STREPTOZOCIN; THROMBOMODULIN; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 0033920684     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(00)00216-4     Document Type: Article

References (35)

1. Ishii H. The detection and measurement of thrombomodulin. Giddings J.C. Thrombomodulin and the Control of Hematostasis. 1994;121-141 RG Landes Company, Austin, TX.
2. Esmon C.T., Owen W.G. Identification of endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci USA. 78:1981;2249-2252.
3. Esmon C.T. The role of protein C and thrombomodulin in the regulation of blood coagulation. J Biol Chem. 264:1989;4743-4746.
4. Dittman W.A., Majerus P.W. Structure and function of thrombomodulin. A natural anticoagulant. Blood. 75:1990;329-336.
5. Koyama T., Parkinson J.F., Sie P., Bang N.U., Muller-Berghaus G., Preissner K.T. Different glycoforms of human thrombomodulin. Eur J Biochem. 198:1991;563-570.
6. Jackman R.W., Beeler D.L., Vandewater L., Rosenberg R.D. Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor. Proc Natl Acad Sci USA. 83:1986;8834-8838.
7. Kumada T., Dittman W.A., Majerus P.W. A role for thrombomodulin in the pathogenesis of thrombin-induced thromboembolism in mice. Blood. 71:1988;728-733.
8. Salem H.H., Maruyama I., Ishii H., Majerus P.W. Isolation and characterization of thrombomodulin from human placenta. J Biol Chem. 259:1984;12246-12251.
9. Dittman W.A., Kumada T., Sadler E., Majerus P.W. The structure and function of mouse thrombomodulin. J Biol Chem. 263:1988;15815-15822.
10. Wang J., Yao A., Wang J.Y., Sung C.C., Fink L.M., Hardin J.W., Hauer-Jensen M. cDNA cloning and sequencing, gene expression, and immunolocalization of thrombomodulin in the Sprague-Dawley rat. DNA Res. 26:1999;57-62.
11. Suzuki K., Kusumoto S., Deyashiki Y., Nishioka J., Maruyama I., Zushi M., Kawahara S., Honda G., Yamamoto S., Horiguchi S. Structure and expression of human TM, a thrombin receptor on endothelium acting as a cofactor for protein C activation. EMBO J. 6:1987;1891-1897.
12. Suzuki K., Hayashi T., Nishioka J., Kosaka Y., Zushi M., Honada G., Yamamoto S. A domain composed of epidermal growth factor-like structures of human TM is essential for thrombin binding and protein C activation. J Biol Chem. 264:1989;4872-4876.
13. Hayashi T., Suzuki K. Monoclonal antibodies for human TM which recognize binding sites for thrombin and protein C. J Biochem (Tokyo). 108:1990;874-878.
14. Bourin M.C., Ohlin A.K., Lane D.A., Stenfro J., Lindahl U. Relationship between anticoagulant activities and polyanionic properties of rabbit thrombomodulin. J Biol Chem. 263:1988;8044-8052.
15. Ishii H., Majerus P.W. Thrombomodulin is present in human plasma and urine. J Clin Invest. 76:1985;2178-2181.
16. Ishii H., Nakano M., Tsubouchi J., Ishikawa T., Uchiyama H., Hiraishi S., Tahara C., Miyajima Y., Kazama M. Establishment of enzyme immunoassay of human thrombomodulin in plasma and urine using monoclonal antibodies. Thromb Haemost. 63:1990;157-162.
17. Nakano M., Furutani M., Hiraishi S., Ishii H. Characterization of soluble thrombomodulin fragments in human urine. Thromb Haemost. 79:1998;331-337.
18. Ishii H., Uchiyama H., Kazama M. Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells. Thromb Haemost. 65:1991;618-623.
19. Shimano H., Takahashi K., Kawakami M., Gotoda T., Harada K., Shimada M., Yazaki Y., Yamada N. Elevated serum and urinary thrombomodulin levels in patients with non-insulin-dependent diabetes mellitus. Clinica Chimica Acta. 225:1994;89-96.
20. Amano K., Tateyama M., Inaba H., Fukutake K., Fujimaki M. Fluctuations in plasma levels of thrombomodulin in patients with DIC. Thromb Haemost. 68:1992;404-406.
21. Kazama M. Clinical elevation of hemostatic molecular markers. Acta Hematol. 51:1988;1387-1394.
22. Daimon T., Kazama M., Miyajima Y., Nakano M. Immunocytochemical localization of thrombomodulin in the aqueous humor passage of the rat eye. Histochem Cell Biol. 108:1997;121-131.
23. Takatori M., Iwabuchi S., Ro S., Maruyama M., Maeyama S., Uchikoshi T., Nakano M., Ishii H. Increased serum levels and sinusoidal expression of thrombomodulin in acute liver damage. Thromb Res. 93:1999;113-120.
24. Menashi S., Aurousseau M.H., Gozin D., Daffos F., D'Angelo A., Forestier F., Boffa M.C. High levels of circulating thrombomodulin in human foetuses and children. Thromb Haemost. 81:1999;906-909.
25. Imada M., Imada S., Iwasaki H., Kume A., Yamaguchi H., Moore E.E. Fetomodulin. marker surface protein of fetal development which is modulatable by cyclic AMP Dev Biol. 122:1987;483-491.
26. Imada S., Yamaguchi H., Nagumo M., Katayanagi S., Iwasaki H., Imada M. Identification of fetomodulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional assays. Dev Biol. 140:1990;113-122.
27. Ford V.A., Wilkinson J.E., Kennel S.J. Thrombomodulin distribution during murine development. Roux's Arch Dev Biol. 202:1993;364-370.
28. Healy A.M., Rayburn H.B., Rosenberg R.D., Weiler H. Absence of the blood-clotting regulator thrombomodulin causes embryonic lethality in mice before development of a functional cardiovascular system. Proc Natl Acad Sci USA. 92:1995;850-854.
29. Hamada H., Ishii H., Sakyo K., Horie S., Nishiki K., Kazama M. The epidermal growth factor-like domain of recombinant human thrombomodulin exhibits mitogenic activity for Swiss 3T3 cells. Blood. 861:1995;225-233.
30. Tohda G., Oida K., Okada Y., Kosaka S., Okada E., Takahashi S., Ishii H., Miyamori I. Expression of thrombomodulin in atherosclerotic lesions and mitogenic activity of recombinant thrombomodulin in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 18:1998;1861-1869.
31. Oida K., Takai H., Maeda H., Takahashi S., Tamai T., Nakai T., Miyabo S., Ishii H. Plasma thrombomodulin concentration in diabetes mellitus. Diabetes Res Clin Pract. 10:1990;193-196.
32. Tanaka A., Ishii H., Hiraishi S., Kazama M., Maezawa H. Increased thrombomodulin values in plasma of diabetic men with microangiopathy. Clin Chem. 37:1991;269-272.
33. Handa H., Uehara S., Honjo K., Tsuji Y., Ohi M., Hirayama K. Characteristics of plasma thrombomodulin in patients with diabetes mellitus. Int J Hematol. 63;740. 1996;. [meeting abstract in Japanese].
34. Garg M.C., Ojha S., Bansal D.D. Antioxidant status of streptozotocin diabetic rats. Indian J Exp Biol. 34:1996;264-266.
35. Hosaka Y., Takahashi Y., Ishii H. Thrombomodulin in human plasma contributes to inhibit fibrinolysis through acceleration of thrombin-dependent activation of plasma procarboxypeptidase B. Thromb Haemost. 79:1998;371-377.