DNA strand scission by the nephrotoxin [2,2'-bipyridine]-3,3',4,4'- tetrol-1,1'-dioxide and related compounds in the presence of iron

Free Radical Research

Volumn 33, Issue 2, 2000, Pages 129-137

  Cantin Esnault, Danielle ^a   Oubrahim, Hammou ^b   Richard, Jean Michel ^c  

^a Université Joseph Fourier   (France)

^b UNIV GRENOBLE ALPES   (France)

^c NONE

Author keywords

DNA strand scission; ESR; Iron complex; Mushroom nephrotoxin; Orellanine; Oxy radical

Indexed keywords

AMINE OXIDE; BIPYRIDINE DERIVATIVE; CATALASE; CHELATING AGENT; CYSTEINE; DEFEROXAMINE MESYLATE; DIMETHYL SULFOXIDE; DNA; EDETIC ACID; FERROUS ION; IRON; ORELLANINE; OXYGEN; PENTETIC ACID; SUPEROXIDE DISMUTASE; TOXIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND; ELECTRON SPIN RESONANCE;

BASIDIOMYCOTA; OXY;

EID: 0033919906     PISSN: 10715762     EISSN: None     Source Type: Journal    
DOI: 10.1080/10715760000300681     Document Type: Article

References (14)

1. H. Oubrahim, J.-M. Richard, D. Cantin-Esnault, F. Seigle-Murandi and F. Trécourt (1997) Novel methods for identification and quantification of the mushroom nephrotoxin orellanine. Thin-layer chromatography and electrophoresis screening of mushrooms with electron spin resonance determination of the toxin. Journal of Chromatography A, 758, 145-157.
2. J.-M. Richard, D. Cantin-Esnault and A. Jeunet (1995) First electron spin resonance evidence for the production of semiquinone and oxygen free radicals from orellanine, a mushroom nephrotoxin. Free Radical Biology and Medicine, 19, 417-429.
3. D. Cantin-Esnault, J.-M. Richard and A. Jeunet (1997) Generation of oxygen radicals from iron complex of orellanine, a mushroom nephrotoxin; preliminary ESR and spin-trapping studies. Free Radical Research, 28, 45-58.
4. D. Cantin, J.-M. Richard and J. Alary (1989) Chromatographic behaviour and determination of orellanine, a toxin from the mushroom Cortinarius orellanus. Journal of Chromatography, 478, 231-237.
5. F. Trécourt, M. Mallet, O. Mongin, B. Gervais and G. Quéguiner (1993) New synthesis of orelline by metalation of methoxypyridines. Tetrahedron, 49, 8373-8380.
6. D. Cantin, J.-M. Richard, J. Alary and D. Serve (1988) Electrochemical study of the mushroom toxin orellanine and of related pyridine-1-oxides: 1. Reduction. Electrochimica Acta, 33, 1047-1059.
7. J.-M. Richard, D. Cantin-Esnault, C. Dumont and J.-L. Benoit-Guyod (1991) Détermination des pK et des équilibres acido-basiques d'une toxine d'origine fongique, l'orellanine. Analysis, 19, 236-243.
8. W.A. Pry (1994) Oxidants and antioxidants: Free radicals and lipid peroxidation: What they are and how they got that way. In Natural Antioxidants in Human Health and Disease (Ed. B. Frei), Academic Press, San Diego, pp. 1-24.
9. S.E. Hudson and P.K. Mascharak (1989) Radical-induced DNA damage by a synthetic analogue of copper(II)-bleomycin. Chemical Research in Toxicology, 2, 411-415.
10. B. Halliwell and J.M.C. Gutteridge (1990) Role of free radicals and catalytic metal ions in human disease: An overview. In Methods in Enzymology (Eds. L. Packer and A.N. Glazer), Vol. 186, Academic Press, New York, pp. 1-85.
11. J.-M. Richard, J. Louis and D. Cantin (1988) Nephrotoxicity of orellanine, a toxin from the mushroom Cortinarius orellanus. Archives of Toxicology, 62, 242-245.
12. W. Pfaller, G. Gstraunthaler, H. Prast, L. Rupp, C. Ruedl, S. Michelitsch and M. Moser (1991) Effects of the fungal toxin orellanine on renal epithelium. In Nephrotoxicity: Mechanisms, Early Diagnosis and Therapeutic Management (Eds. P.H. Bach, N.T. Gregg, M.F. Wilks and L. Delacruz), Marcel Dekker, New York, pp. 63-69.
13. J.-M. Richard, G. Taillandier and J.-L. Benoit-Guyod (1985) A quantitative structure-activity relationship study on substituted pyridines as a contribution to the knowledge of the toxic effects of orellanine, a toxin from the mushroom Cortinarius orellanus. Toxicon, 23, 815-824.
14. J.-M. Richard, E.E. Creppy, J.-L. Benoit-Guyod and G. Dirheimer (1991) Orellanine inhibits protein synthesis in Madin-Darby canine kidney cells, in rat liver mitochondria and in vitro: indication for its activation prior to in vitro inhibition. Toxicology, 67, 53-62.