Rectal absorption of lamotrigine compressed tablets

Epilepsia

Volumn 41, Issue 7, 2000, Pages 850-853

  Birnbaum, Angela K ^a   Kriel, Robert L ^a,b,c   Burkhardt, R Todd ^a   Remmel, Rory P ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b HENNEPIN COUNTY MEDICAL CENTER   (United States)

^c GILLETTE CHILDREN'S SPECIALTY HEALTHCARE   (United States)

Author keywords

Antiepileptic; Bioavailability; Compressed; Lamotrigine; Rectal

Indexed keywords

LAMOTRIGINE;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DETERMINATION; EPILEPSY; HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; TABLET;

EID: 0033919212     PISSN: 00139580     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1528-1157.2000.tb00252.x     Document Type: Article

References (19)

1. Cloyd JC, Kriel RL. Bioavailability of rectally administered valproic acid syrup. Neurology 1981;31:1348-52.
2. Graves NM, Kriel RL, Jones-Saete C, Cloyd JC. Relative bioavailability of rectally administered carbamazepine suspension in humans. Epilepsia 1985;26:429-33.
3. Graves NM, Kriel RL, Jones-Saete C. Bioavailability of rectally administered lorazepam. Clin Neuropharmacol 1987;10:555-9.
4. Dreifuss FE, Rosman NP, Cloyd JC, et al. A comparison of rectal diazepam gel and placebo for acute repetitive seizures. N Engl J Med 1998;338:1869-75.
5. Kriel RL, Cloyd JC, Hadsall RS, Carlson AM, Floren KL, Jones-Saete CM. Home use of rectal diazepam for cluster and prolonged seizures: efficacy, adverse reactions, quality of life, and cost analysis. Pediatr Neurol 1991;7:13-7.
6. Graves NM, Holmes GB, Kriel RL, Jones-Saete C, Ong B, Ehresman DJ. Relative bioavailability of rectally administered phenobarbital sodium parenteral solution. Ann Pharmacother 1989;23: 565-8.
7. Curless RG, Holzman BH, Ramsay RE. Paraldehyde therapy in childhood status epilepticus. Arch Neurol 1983;40:477-80.
8. Kriel RL, Birnbaum AK, Cloyd JC, Ricker BJ, Jones-Saete C, Caruso KJ. Failure of absorption of gabapentin after rectal administration. Epilepsia 1997;38:1242-4.
9. Fuerst RH, Graves NM, Kriel RL, Olson R. Absorption and safely of rectally administered phenytoin. Eur J Drug Metab Pharmacokinet 1988;13:257-60.
10. Sinz MW, Remmel RP. Analysis of lamotrigine and lamotrigine 2-N-glucuronide in guinea pig blood and urine by reversed-phase ion-pairing liquid chromatography. J Chromatogr 1991;571:217-30.
11. Gibaldi M, Perrier D. Pharmacokinetics. New York: Mercel Dekker, 1975:281-92.
12. Pagay SN, Poust RI, Colaizzi JL. Influence of vehicle dielectric properties on acetaminophen bioavailability from polyethylene glycol suppositories. J Pharm Sci 1974;63:44-7.
13. Moolenaar F, Ensing JG, Bolhuis BG, Visser J. Absorption rate and bioavailability of promethazine from rectal and oral dosage forms. Int J Pharmaceut 1981;9:353-7.
14. Moolenaar F, Bakker S, Visser J, HuizingaT. Biopharmaceutics of rectal administration of drugs in man: IX. Comparative biopharmaceutics of diazepam after single rectal, oral, intramuscular and intravenous administration in man. Int J Pharmaceut 1980;5:127-37.
15. Wagner JG, Carter CH, Martens IJ. Serum concentrations after rectal administration of lincomycin hydrochloride. J Clin Pharmacol 1968;8:154-63.
16. Muranishi S. Characteristics of drug absorption via the rectal route. In: Glas B, deBlaey CJ, eds. Proceedings of the symposium on the advantages and problems encountered in rectal therapy. Barcelona: J R Prous, 1984;35-44.
17. deBoer AG, Moolenaar F, deLeede LGJ, Breimer DD. Rectal drug administration: clinical pharmacokinetic considerations. Clin Pharmacokinet 1982;7:285-311.
18. Hogben CAM, Tocco DJ, Brodie BB, Schanker LS. On the mechanism of intestinal absorption of drugs. J Pharmacol Exp Ther 1959;125:275-82.
19. Shore PA, Brodie BB, Hogben CAM. The gastric secretion of drugs: a pH partition hypothesis. J Pharmacol Exp Ther 1957;119: 361-9.