Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii

Scandinavian Journal of Immunology

Volumn 52, Issue 1, 2000, Pages 91-95

  Milano, S ^c   D'Agostino, P ^c   Di Bella, G ^c   La Rosa, M ^c   Barbera, C ^c   Ferlazzo, V ^c   Mansueto, P ^a   Rini, G B ^a   Barera, A ^a   Vitale, G ^a   Mansueto, S ^a   Cillari, E ^b  

^a UNIVERSITY OF PALERMO   (Italy)

^b VILLA SOFIA CERVELLO HOSPITAL   (Italy)

^c Microbiol/Virol Labs c/o PM C ^*

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 12; RECOMBINANT GAMMA INTERFERON;

ARTICLE; BOUTONNEUSE FEVER; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG RESPONSE; HUMAN; HUMAN CELL; MONONUCLEAR CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RICKETTSIA CONORII; T LYMPHOCYTE SUBPOPULATION; TH1 CELL;

BOUTONNEUSE FEVER; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; LEUKOCYTES, MONONUCLEAR; RICKETTSIA CONORII;

EID: 0033916930     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.2000.00743.x     Document Type: Article

References (25)

1. 1 Wolbach SB, Todd JL, Palfrey FW. Pathology of typhus in man. In: Wolbach SB, Todd JL, Palfrey FW, eds. The Aetiology and Pathology of Typhus. Cambridge, MA: League of Red Cross Societies at Harvard University Press, 1922:152-221.
2. 2 Walker DH, Mattern WD. Rickettsial vasculitis. Am Heart J 1980;100:896-906.
3. 3 Cillari E, Milano S, D'Agostino P, et al. Depression of CD4 T-cell subsets and alteration in cytokine profile in boutonneuse fever. J Infect Dis 1996;174:1051-7.
4. 4 Herrero-Herrero JI, Walker DH, Ruiz-Beltran R. Immunohistochemical evaluation of the cellular immune response to Rickettsia conorii in Taches noires. J Infect Dis 1987;155:802-5.
5. 5 Mansueto S, Vitale G, Cillari E, et al. High levels of interferon-γ in boutonneuse fever. J Infect Dis 1994;170:1637-8.
6. 6 Oristrell J, Amengual MJ, Font-Creus B, et al. Plasma levels of tumour necrosis factor-α in patients with spotted fever: clinical and analytical correlations. Clin Infect Dis 1994;19:1141-3.
7. 7 D'Andrea A, Aste-Amegaza M, Valiante NM, et al. Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J Exp Med 1993;178:1041-9.
8. 8 Bogdan C, Vodovotz Y, Nathan C. Macrophage deactivation by interleukin 10. J Exp Med 1995;174:1549-57.
9. 9 Sher A, Grassinelli RT, Oswald IP, et al. Role of T-cell derived cytokines in the downregulation of immune responses in parasitic and retroviral infection. Immunol Rev 1992;127:183-204.
10. 10 Gately MK, Renzetti LM, Magram J, et al. The interleukin-12/ interleukin-12-receptor system: role in normal and pathologic immune response. Annu Rev Immunol 1998;16:495-521.
11. 11 Adorini L. IL-12. Chem Immunol 1997;68:1-205.
12. 12 D'Andrea A, Rengaraju M, Valiante NM, et al. Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J Exp Med 1992;176:1387-98.
13. 13 Mansueto S, Vitale G, Mocciaro C, et al. Laboratory diagnosis of boutonneuse fever by enzyme-linked immunosorbent assay. Trans R Soc Trop Med Hyg 1989;83:855-7.
14. 14 Philip RN, Casper EA, Burgdofer W, et al. Serologic typing of rickettsiae of the spotted fever group by microimmunofluorescence. J Immunol 1978;121:1961-8.
15. 15 Nabors GS. Modulating ongoing Th2-cell responses in experimental leishmaniasis. Parasitol Today 1997;13:76-9.
16. 16 Silverman DJ, Bond SB. Infection of human vascular endothelium cells by Rickettsia conorii. J Infect Dis 1984;149:201-26.
17. 17 Raoult D, Weiller PJ, Chagnon A, et al. Mediterranean spotted fever: clinical, laboratory, and epidemiological features of 199 cases. Am J Trop Med Hyg 1986;35:845-50.
18. 18 Vincente V, Albera I, Ruiz R, et al. Coagulation abnormalities in patients with spotted fever. J Infect Dis 1986;153:128-31.
19. 19 George F, Brouqui P, Boffa MC, et al. Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean Spotted Fever. Blood 1993;82: 2109-16.
20. 20 Tripp CS, Wolf SF, Unanue ER. Interleukin 12 and tumour necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc Natl Acad Sci USA 1993;90:3725-9.
21. 21 Ghalib HW, Whittle JA, Kubin M, et al. IL-12 enhances Th1-type responses in human Leishmania donovani infections. J Immunol 1995;154:4623-9.
22. 22 Gazzinelli RT, Wysocka M, Hayashi S, et al. Parasite-induced IL-12 stimulates early IFN-γ synthesis and resistance during acute infection with Toxoplasma gondii. J Immunol 1994;153:2533-43.
23. 23 Tripp CS, Gately MK, Hakimi J, et al. Neutralization of IL-12 decreases resistance to Lysteria in SCID and C.B.-17 mice. Reversal by IFN-γ. J Immunol 1994;152:1883-7.
24. 24 Cooper AM, Roberts AD, Rhoades ER, et al. The role of interleukin-12 in acquired immunity to Mycobacterium tuberculosis. Immunology 1995;84:423-32.
25. 25 Scharton-Kerston T, Afonso LC, Wysocka M, et al. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J Immunol 1995;154: 5320-30.