Lysosomotropic detergents induce time- and dose-dependent apoptosis/necrosis in cultured cells

Redox Report

Volumn 5, Issue 2-3, 2000, Pages 87-88

  Brunk, U T ^a  

^a LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL SERINE DODECYLAMIDE HYDROCHLORIDE; CASPASE; CYSTEINE PROTEINASE; CYTOCHROME C; DETERGENT; HYDROLASE; SPHINGOSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LYSOSOME; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALIA;

EID: 0033916490     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1179/135100000101535609     Document Type: Article

References (9)

1. Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage
2. Oxidative stress, growth-factor starvation, and FAS-activation may all cause apoptosis through lysosomal leak
3. Lysosomotropic agents I. Synthesis and cytotoxic action of lysosomotropic detergents
4. Commentary: Lysosomotropic agents
5. Atractyloside-induced release of cathepsin B, a protease with caspase- processing activity
6. Activation of caspase-3-like protease by digitonin-treated lysosomes
7. Cytochemical evidences for leakage of acid phosphatase through ultrastructurally intact lysosomal membranes
8. Lysosomal heterogeneity within and between cells with respect to resistance to oxidative stress
9. The lysosome in retrospect