Increases in clitoral and vaginal blood flow following clitoral and pelvic plexus nerve stimulations in the female rat

International Journal of Impotence Research

Volumn 12, Issue 1, 2000, Pages 53-57

  Vachon, P ^a   Simmerman, N ^a   Zahran, A R ^a   Carrier, S ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Blood flow; Female; Laser Doppler; Nerve stimulation; Rat

Indexed keywords

ANIMAL TISSUE; ARTICLE; BLOOD FLOW; CLITORIS; EXCITATION; FEMALE; FEMALE SEXUAL DYSFUNCTION; LASER DOPPLER FLOWMETRY; NERVE PLEXUS; NERVE STIMULATION; NONHUMAN; PELVIC NERVE; PHARMACOLOGY; PHYSIOLOGY; PRIORITY JOURNAL; RAT; SEXUAL BEHAVIOR; VAGINA;

EID: 0033915453     PISSN: 09559930     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ijir.3900480     Document Type: Article

References (32)

1. Diagnostic and Statistical Manual of Mental Disorders, 4th ed., American Psychiatric Association, Washington, D.C., p 494.
2. Weisberg M. Physiology of female sexual function. Clin Obst Gynecol 1984; 27: 697-705.
3. Stern MD. In vivo evaluation of microcirculation by coherent light scattering. Nature 1975; 254: 56-58.
4. Baljet B, Drukker J. The extrinsic innervation of the pelvic organs in the female rat. Acta Anat 1980; 107: 241-267.
5. Langworthy OR. Innervation of the pelvic organs of the rat. Invest Urol 1965; 2: 491-511.
6. Levin RJ. The mechanisms of human female sexual arousal. Annu Rev Sex Res 1992; 3: 1-48.
7. Azadzoi KM, Vlachiotis J, Pontari M, Siroky MB. Hemodynamics of penile erection: III. measurement of deep intracavernosal and subtunical blood flow and oxygen tension. J Urol 1995; 153: 521-526.
8. Dail WG, Walton G, Oamsted MP. Penile erection in the rat: stimulation of the hypogastric nerve elicits increases in penile pressure after chronic interruption of the sacral parasympathetic outflow. J Auton Nerv Syst 1989; 28: 251-257.
9. Lue TF et al. Hemodynamics of erection in the monkey. J Urol 1983; 130: 1237-1241.
10. Quinlan DM et al. The rat as a model for the study of penile erection. J Urol 1989; 141: 656-661.
11. Rampin O, Giuliano F, Dompeyre P, Rousseau J-P. Physiological evidence of neural pathways involved in reflexogenic penile erections. Neurosc Lett 1994; 180: 138-142.
12. Vardi Y, Siroky MB. A canine model for hemodynamic study of isolated corpus cavernosum. J Urol 1987; 138: 663-666.
13. Burnett AL et al. Nitric oxide: a physiologic mediator of penile erection. Science 1992; 257: 401-403.
14. Toesca A, Stolf VM, Cocchia D. Immunohistochemical study of the corpora cavernosa of the human clitoris. J Anat 1996; 188: 513-520.
15. Burnett AL et al. Immunohistochemical description of nitric oxide synthase isoforms in human clitoris. J Urol 1997; 158: 75-78.
16. Hoyle CH, Sones RW, Robson T, Burnstock G. Innervation of vasculature and microvasculature of the human vagina by NOS and neuropeptide-containing nerves. J Anat 1996; 188: 633-644.
17. Batra S, Al-Hijji J. Characterization of nitric oxide synthase activity in rabbit uterus and vagina: downregulation by estrogen. Life Sciences 1998; 62: 2093-2100.
18. Berman JR, McCarthy MM, Kyprianou N. Effect of estrogen withdrawal on nitric oxide synthase expression and apoptosis in the rat vagina. Urology 1998; 51: 650-656.
19. Chatterjee S, Gangula PRR, Dong Y-L, Yallampalli C. Immunocytochemical localization of nitric oxide-III in reproductive organs of female rats during the oestrus cycle. J Histochem 1996; 28: 715-723.
20. Grozdanovic Z, Mayer B, Baumgarten HG, Brüning G. Nitric oxide synthase-containing nerve fibres and neurons in the genital tract of the female mouse. Cell Tissue Res 1994; 275: 355-360.
21. Majewski M et al. The distribution and co-localization of immunoreactivity to nitric oxide synthase, vasoactive intestinal polypeptide and substance P within nerve fibres supplying bovine and porcine female genital organs. Cell Tissue Res 1995; 281: 445-464.
22. Inyama CO et al. Distribution of vasoactive intestinal polypeptide binding sites in guinea pig genital tissues. Neurosci Lett 1987; 81: 111-116.
23. Blank MA et al. The regional distribution of NPY-, PHM-, and VIP-containing nerves in the human female genital tract. Int J Fert 1986; 313: 218-222.
24. Bredkjoer HE et al. PreproVIR-derived peptides in the human female genital tract: expression and biological function. Neuropeptides 1997; 31: 209-215.
25. Ottesen B et al. Vasoactive intestinal polypeptide (VIP) provokes vaginal lubrication in normal women. Peptides 1987; 8: 797-800.
26. Palle C, Bredkjaer HE, Ottesen B, Fahrenkrug J. Vasoactive intestinal polypeptide and human vaginal blood flow: comparison between transvaginal and intravenous administration. Clin Exp Pharmacol Physiol 1990; 17: 61-68.
27. Palle C, Bredkjaer HE, Fahrenkrug J, Ottesen B. Vasoactive intestinal polypeptide loses its ability to increase vaginal blood flow after menopause. Am J Obst Gynecol 1991; 164: 556-558.
28. Park K et al. Vasculogenic female sexual dysfunction; The hemodynamic basis for vaginal engorgement insufficiency and clitoral erectile insufficiency. Int J Impot Res 1997; 9: 27-37.
29. Diederichs W, Lue TF, Tanagho EA. Clitoral response to cavernous nerve stimulation in dogs. Int J Impot Res 1991; 3: 7-13.
30. Semmens JP, Semmens EC. Sexual function and the menopause. Clin Obst Gynecol 1984; 27: 717-723.
31. Enzlin P, Mathieu C, Vanderschueren D, Demyttenaera K. Diabetes mellitus and female sexuality: a review of 25 years research. Diabet Med 1998; 15: 809-815.
32. McKenna KE, Chung SK, McVary KT. A model for the study of sexual function in anesthetized male and female rats. Am J Physiol 1991; 261: R1276-R1285.